SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000491 
UniProt Accession
Theoretical PI
UNDEFINED  
Molecular Weight
44297 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
ESX1 
Gene Synonyms/Alias
ESX1L, ESX1R 
Protein Name
Homeobox protein ESX1 Homeobox protein ESX1-N Homeobox protein ESX1-C 
Protein Synonyms/Alias
Extraembryonic, spermatogenesis, homeobox 1;Contains:Contains: 
Organism
Homo sapiens (Human) 
NCBI Taxonomy ID
9606 
Chromosome Location
chr:X;103494719-103499614;-1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
ESX1 emerges as a potentially reliable spermatogenesis molecular marker, whose clinical value as a predictor of successful sperm retrieval warrants further studies. 
The information of related literatures
1. E. Bonaparte, M. Moretti, G. M. Colpi, F. Nerva, G. Contalbi, L. Vaccalluzzo, S. Tabano, F. R. Grati, G. Gazzano, S. M. Sirchia, G. Simoni, A. Gallina and M. Miozzo (2010) ESX1 gene expression as a robust marker of residual spermatogenesis in azoospermic men. Hum Reprod 25(6): 1398-403. 

Abstract
BACKGROUND PMID: [20356899] 

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Figures for illustrating the function of this protein/gene
Function
May coordinately regulate cell cycle progression andtranscription during spermatogenesis. Inhibits degradation ofpolyubiquitinated cyclin A and cyclin B1 and thereby arrests thecell cycle at early M phase. ESXR1-N acts as a transcriptionalrepressor. Binds to the sequence 5'-TAATGTTATTA-3' which ispresent within the first intron of the KRAS gene and inhibits itsexpression. ESXR1-C has the ability to inhibit cyclin turnover. 
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Subcellular Location
Cytoplasm. Nucleus. Note=ESXR1-N localizesspecifically to the nucleus while ESXR1-C localizes specificallyto the cytoplasm. 
Tissue Specificity
Expressed in placenta and testis. Expressed intesticular germ cell tumors. 
Gene Ontology
GO IDGO termEvidence
GO:0005737 C:cytoplasm IDA:UniProtKB.
GO:0005634 C:nucleus IDA:UniProtKB.
GO:0043565 F:sequence-specific DNA binding IDA:UniProtKB.
GO:0003700 F:sequence-specific DNA binding transcription factor activity IEA:InterPro.
GO:0060716 P:labyrinthine layer blood vessel development IEA:Compara.
GO:0060713 P:labyrinthine layer morphogenesis IEA:Compara.
GO:0045892 P:negative regulation of transcription, DNA-dependent IDA:UniProtKB.
GO:0051726 P:regulation of cell cycle IDA:UniProtKB.
GO:0006357 P:regulation of transcription from RNA polymerase II promoter IEA:Compara.
GO:0006351 P:transcription, DNA-dependent IEA:UniProtKB-KW.
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Interpro
IPR017970;    Homeobox_CS.
IPR001356;    Homeodomain.
IPR009057;    Homeodomain-like.
IPR013847;    POU.
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Pfam
PF00046;    Homeobox;    1.
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SMART
SM00389;    HOX;    1.
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PROSITE
PS00027;    HOMEOBOX_1;    1.
PS50071;    HOMEOBOX_2;    1.
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PRINTS
PR00028;    POUDOMAIN.;   
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Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1    406       Homeobox protein ESX1.
                             /FTId=PRO_0000048876.
CHAIN         1      ?       Homeobox protein ESX1-N.
                             /FTId=PRO_0000386625.
CHAIN         ?    406       Homeobox protein ESX1-C.
                             /FTId=PRO_0000386626.
REPEAT      244    252       1.
REPEAT      253    261       2.
REPEAT      262    270       3.
REPEAT      271    279       4.
REPEAT      280    288       5.
REPEAT      289    297       6.
REPEAT      298    306       7.
REPEAT      307    315       8.
REPEAT      316    324       9.
REPEAT      325    333       10.
REPEAT      334    342       11.
REPEAT      343    351       12.
REPEAT      352    360       13.
REPEAT      361    369       14.
REPEAT      370    378       15.
DNA_BIND    139    198       Homeobox.
REGION      244    378       15 X 9 AA tandem repeats of P-P-x-x-P-x-
                             P-P-x.
MOTIF       138    143       Nuclear localization signal (Potential).
VARIANT     314    314       T -> P (in dbSNP:rs9697856).
                             /FTId=VAR_059352.
CONFLICT    320    320       P -> R (in Ref. 5; AAH42633/AAH53599).
CONFLICT    338    339       RV -> PL (in Ref. 5; AAH42633/AAH53599).
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Nucleotide Sequence
Length: 1451 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 406 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
Dlg4MINT 
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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