SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000501 
UniProt Accession
Theoretical PI
5.52  
Molecular Weight
54255 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
LRRC6 
Gene Synonyms/Alias
LRTP, TSLRP 
Protein Name
Protein TILB homolog 
Protein Synonyms/Alias
Leucine-rich repeat-containing protein 6; Leucine-rich testis-specific protein; Testis-specific leucine-rich repeat protein; 
Organism
Homo sapiens (Human) 
NCBI Taxonomy ID
9606 
Chromosome Location
chr:8;133584320-133687838;-1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Immunohistochemical localization is markedly reduced in secondary spermatocytes, suggesting a functional association of LRTP with meiosis. 
The information of related literatures
1. J. C. Xue and E. Goldberg (2000) Identification of a novel testis-specific leucine-rich protein in humans and mice. Biol Reprod 62(5): 1278-84. 

Abstract
A novel testis-specific protein, termed LRTP, was identified by screening both human and mouse testis and mouse pachytene spermatocyte cDNA libraries. Sequence analyses (GenBank accession number PMID: [10775177] 

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Figures for illustrating the function of this protein/gene
Ref: J. C. Xue and E. Goldberg (2000) Identification of a novel testis-specific leucine-rich protein in humans and mice. Biol Reprod 62(5): 1278-84. PMID: [10775177]
Ref: J. C. Xue and E. Goldberg (2000) Identification of a novel testis-specific leucine-rich protein in humans and mice. Biol Reprod 62(5): 1278-84. PMID: [10775177]
Function
Plays a role in motility of cilia (By similarity). 
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Subcellular Location
Cytoplasm (By similarity). Cell projection(By similarity). 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0005929 C:cilium IEA:UniProtKB-KW.
GO:0005737 C:cytoplasm ISS:BHF-UCL.
GO:0000240 P:diplotene ISS:BHF-UCL.
GO:0008584 P:male gonad development ISS:BHF-UCL.
GO:0000239 P:pachytene ISS:BHF-UCL.
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Interpro
IPR007052;    CS-like_domain.
IPR001611;    Leu-rich_rpt.
IPR025875;    Leu-rich_rpt_2_copies.
IPR003603;    U2A'_phosphoprotein32A_C.
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Pfam
PF12799;    LRR_4;    1.
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SMART
SM00446;    LRRcap;    1.
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PROSITE
PS51203;    CS;    1.
PS51450;    LRR;    5.
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PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1    466       Protein TILB homolog.
                             /FTId=PRO_0000084496.
REPEAT       22     43       LRR 1.
REPEAT       45     66       LRR 2.
REPEAT       67     88       LRR 3.
REPEAT       89    110       LRR 4.
DOMAIN      123    161       LRRCT.
DOMAIN      301    396       CS.
COILED      178    204       Potential.
COMPBIAS    281    286       Poly-Lys.
VAR_SEQ     409    414       RSKHME -> SYSTGF (in isoform 2).
                             /FTId=VSP_015862.
VAR_SEQ     415    466       Missing (in isoform 2).
                             /FTId=VSP_015863.
VARIANT     232    232       T -> I (in dbSNP:rs2293979).
                             /FTId=VAR_023603.
VARIANT     466    466       I -> T (in dbSNP:rs9297853).
                             /FTId=VAR_031223.
CONFLICT    242    244       Missing (in Ref. 1; AAB02976).
CONFLICT    349    351       Missing (in Ref. 2; AAH27589).
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Nucleotide Sequence
Length: 2446 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 466 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data
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