SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000503 
UniProt Accession
Theoretical PI
5.39  
Molecular Weight
32177 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
CDKN1C 
Gene Synonyms/Alias
KIP2 
Protein Name
Cyclin-dependent kinase inhibitor 1C 
Protein Synonyms/Alias
Cyclin-dependent kinase inhibitor p57; p57Kip2; 
Organism
Homo sapiens (Human) 
NCBI Taxonomy ID
9606 
Chromosome Location
chr:11;2904443-2907111;-1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
The possible role of p57kip2 in the regulation of early spermatogonial proliferation, meiotic progression of early spermatocytes and differentiation of Leydig cells in testis. 
The information of related literatures
1. S. T. Kim and M. C. Gye (2004) Expression of p57 in mouse and human testes. Dev Growth Differ 46(6): 495-502. 

Abstract
The expression of cyclin-dependent kinases inhibitors, p57kip2, was investigated during the postnatal development of mouse testis, and in adult human testis. Expression of p57kip2 mRNA was higher in immature than pubertal or adult mouse testes. In postnatal day 7 (PND7) testes, moderate p57kip2 immunoreactivity was found in spermatogonia, but signal was heterogeneous among the spermatogonia. In PND14 testes onward, strong immunoreactivity of p57kip2 was found in the nuclei of early spermatocytes but not in the late pachytene stage onward. In PND28 and PND50 testes, p57kip2 immunoreactivity was varying among the seminiferous tubules. There was no visible signal in late pachytene stage onward. In Leydig cells, heterogeneous immunoreactivity of p57kip2 was found in immature testis and the signal intensity was higher in adult testis than immature ones. In Sertoli cells, weak or negligible immunoreactivity of p57kip2 was found. In human seminiferous tubule, strong immunoreactivity of p57kip2 was found in the nucleus of early spermatocytes, but not in the late pachytene spermatocytes onward and Sertoli cells. These results suggest the possible role of p57kip2 in the regulation of early spermatogonial proliferation, meiotic progression of early spermatocytes and differentiation of Leydig cells in testis. PMID: [15610139] 

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Figures for illustrating the function of this protein/gene
Ref: S. T. Kim and M. C. Gye (2004) Expression of p57 in mouse and human testes. Dev Growth Differ 46(6): 495-502. PMID: [15610139]
Ref: S. T. Kim and M. C. Gye (2004) Expression of p57 in mouse and human testes. Dev Growth Differ 46(6): 495-502. PMID: [15610139]
Function
Potent tight-binding inhibitor of several G1 cyclin/CDKcomplexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and,to lesser extent, of the mitotic cyclin B-CDC2. Negative regulatorof cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. 
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Subcellular Location
Nucleus (By similarity). 
Tissue Specificity
Expressed in the heart, brain, lung, skeletalmuscle, kidney, pancreas and testis. High levels are seen in theplacenta while low levels are seen in the liver. 
Gene Ontology
GO IDGO termEvidence
GO:0005737 C:cytoplasm IDA:BHF-UCL.
GO:0005634 C:nucleus IDA:BHF-UCL.
GO:0004861 F:cyclin-dependent protein kinase inhibitor activity TAS:ProtInc.
GO:0007050 P:cell cycle arrest TAS:ProtInc.
GO:0000080 P:G1 phase of mitotic cell cycle TAS:ProtInc.
GO:0050680 P:negative regulation of epithelial cell proliferation IMP:BHF-UCL.
GO:0000122 P:negative regulation of transcription from RNA polymerase II promoter IEA:Compara.
GO:0045892 P:negative regulation of transcription, DNA-dependent IDA:UniProtKB.
GO:0042551 P:neuron maturation IEA:Compara.
GO:0045893 P:positive regulation of transcription, DNA-dependent IGI:UniProtKB.
GO:0030511 P:positive regulation of transforming growth factor beta receptor signaling pathway IMP:BHF-UCL.
GO:0000079 P:regulation of cyclin-dependent protein kinase activity TAS:ProtInc.
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Interpro
Pfam
PF02234;    CDI;    1.
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SMART
PROSITE
PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1    316       Cyclin-dependent kinase inhibitor 1C.
                             /FTId=PRO_0000190087.
REPEAT      156    159       1.
REPEAT      160    163       2.
REPEAT      180    183       3.
REPEAT      184    187       4.
REPEAT      188    191       5.
REPEAT      198    201       6.
REPEAT      202    205       7.
REPEAT      206    209       8.
REPEAT      210    213       9.
REGION      156    213       9 X 4 AA repeats of P-A-P-A.
MOTIF       278    281       Nuclear localization signal (Potential).
MOD_RES     268    268       Phosphoserine.
VAR_SEQ       1     11       Missing (in isoform Short).
                             /FTId=VSP_000867.
VARIANT     171    174       Missing (in several cancers).
                             /FTId=VAR_001404.
VARIANT     181    184       Missing (in hepatocellular carcinomas).
                             /FTId=VAR_001405.
VARIANT     200    203       Missing (in a bladder cancer).
                             /FTId=VAR_001406.
VARIANT     206    209       Missing (in a breast cancer).
                             /FTId=VAR_001407.
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Nucleotide Sequence
Length: 1511 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 316 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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