SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000506 
UniProt Accession
Theoretical PI
8.63  
Molecular Weight
74354 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
ACSBG2 
Gene Synonyms/Alias
BGR 
Protein Name
Long-chain-fatty-acid--CoA ligase ACSBG2 
Protein Synonyms/Alias
EC=6.2.1.3 Acyl-CoA synthetase bubblegum family member 2; Bubblegum-related protein; PRTD-NY3; 
Organism
Homo sapiens (Human) 
NCBI Taxonomy ID
9606 
Chromosome Location
chr:19;6135710-6193112;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
The BGR gene expands the bubblegum ACS family with a testes-specific, developmentally regulated member that may play a role in spermatogenesis. The BGR-like gene may play an important role in spermatogenesis/testicular development and may be correlated with male infertility. 
The information of related literatures
1. Y. Zheng, Z. M. Zhou, X. Min, J. M. Li and J. H. Sha (2005) Identification and characterization of the BGR-like gene with a potential role in human testicular development/spermatogenesis. Asian J Androl 7(1): 21-32. 

Abstract
AIM PMID: [15685348] 

2. P. Fraisl, H. Tanaka, S. Forss-Petter, H. Lassmann, Y. Nishimune and J. Berger (2006) A novel mammalian bubblegum-related acyl-CoA synthetase restricted to testes and possibly involved in spermatogenesis. Arch Biochem Biophys 451(1): 23-33. 

Abstract
We have characterized a new, membrane-associated acyl-CoA synthetase (ACS), termed bubblegum-related protein (BGR), which upon functional analysis demonstrated ACS activity capable of activating long- and very long-chain fatty acids. By multiple tissue RNA array and Northern blot analyses, human BGR mRNA was exclusively detected in testes. Murine Bgr mRNA was specifically expressed in pubertal and adult testes and was further demonstrated to be enriched in germ cells and Sertoli cells while present at a lower level in Leydig cells both by in situ hybridization and cell type fractionation. The complex 5'-end of the BGR mRNA appears to underlie translational control leading to differential utilization of alternative translation start sites. Thus, the BGR gene expands the bubblegum ACS family with a testes-specific, developmentally regulated member that may play a role in spermatogenesis. PMID: [16762313] 

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Figures for illustrating the function of this protein/gene
Function
Mediates activation of long-chain fatty acids for bothsynthesis of cellular lipids, and degradation via beta-oxidation.Able to activate long-chain fatty acids. Also able to activatevery long-chain fatty acids; however, the relevance of suchactivity is unclear in vivo. Has increased ability to activateoleic and linoleic acid. May play a role in spermatogenesis. 
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Subcellular Location
Cytoplasm. Membrane; Peripheral membraneprotein. 
Tissue Specificity
Testis-specific. 
Gene Ontology
GO IDGO termEvidence
GO:0005829 C:cytosol IEA:Compara.
GO:0016020 C:membrane IEA:UniProtKB-SubCell.
GO:0005792 C:microsome IEA:Compara.
GO:0005739 C:mitochondrion IDA:MGI.
GO:0047617 F:acyl-CoA hydrolase activity IDA:MGI.
GO:0005524 F:ATP binding IEA:UniProtKB-KW.
GO:0004467 F:long-chain fatty acid-CoA ligase activity IDA:MGI.
GO:0030154 P:cell differentiation IEA:UniProtKB-KW.
GO:0007275 P:multicellular organismal development IEA:UniProtKB-KW.
GO:0007283 P:spermatogenesis IEA:UniProtKB-KW.
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Interpro
IPR020845;    AMP-binding_CS.
IPR000873;    AMP-dep_Synth/Lig.
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Pfam
PF00501;    AMP-binding;    1.
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SMART
PROSITE
PS00455;    AMP_BINDING;    1.
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PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1    666       Long-chain-fatty-acid--CoA ligase ACSBG2.
                             /FTId=PRO_0000315812.
NP_BIND     230    238       ATP (By similarity).
NP_BIND     418    423       ATP (By similarity).
BINDING     496    496       ATP (By similarity).
BINDING     624    624       ATP (By similarity).
VAR_SEQ       1    200       Missing (in isoform 4).
                             /FTId=VSP_030717.
VAR_SEQ       1    187       Missing (in isoform 3).
                             /FTId=VSP_030718.
VAR_SEQ       1     50       Missing (in isoform 2).
                             /FTId=VSP_030719.
VARIANT     143    143       V -> A (in dbSNP:rs4807840).
                             /FTId=VAR_038317.
VARIANT     152    152       K -> R (in dbSNP:rs33937754).
                             /FTId=VAR_038318.
VARIANT     584    584       G -> D (in dbSNP:rs17851959).
                             /FTId=VAR_038319.
VARIANT     586    586       G -> D (in dbSNP:rs17851960).
                             /FTId=VAR_038320.
VARIANT     601    601       P -> R (in dbSNP:rs35609668).
                             /FTId=VAR_038321.
VARIANT     624    624       R -> K (in dbSNP:rs17856650).
                             /FTId=VAR_038322.
VARIANT     626    626       E -> Q (in dbSNP:rs17856651).
                             /FTId=VAR_038323.
VARIANT     650    650       R -> S (in dbSNP:rs35605352).
                             /FTId=VAR_038324.
MUTAGEN     511    511       H->R: Results in a shift of the pH
                             optimum to a more acidic pH without
                             affecting substrate specificity.
CONFLICT     71     71       A -> P (in Ref. 4; AAQ89126).
CONFLICT    332    332       K -> E (in Ref. 1; AAG49398).
CONFLICT    595    595       I -> M (in Ref. 2; CAE12156/CAE12157 and
                             3; CAB66788).
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Nucleotide Sequence
Length: 2500 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 666 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
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