SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000515 
UniProt Accession
Theoretical PI
5.46  
Molecular Weight
52358 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
CCNA1 
Gene Synonyms/Alias
 
Protein Name
Cyclin-A1 
Protein Synonyms/Alias
 
Organism
Homo sapiens (Human) 
NCBI Taxonomy ID
9606 
Chromosome Location
chr:13;37005967-37017019;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
cyclin A1 expression is altered in cases of spermatogenic disorders. Moreover, the level of cyclin A1 mRNA expression correlates with gametogenic disorders and seems well suited for a molecular-diagnostic classification supplementing the histopathological evaluation of spermatogenic disorders. 
The information of related literatures
1. M. Schrader, C. Muller-Tidow, S. Ravnik, M. Muller, W. Schulze, S. Diederichs, H. Serve and K. Miller (2002) Cyclin A1 and gametogenesis in fertile and infertile patients. Hum Reprod 17(9): 2338-43. 

Abstract
BACKGROUND PMID: [12202422] 

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Figures for illustrating the function of this protein/gene
Function
May be involved in the control of the cell cycle at theG1/S (start) and G2/M (mitosis) transitions. May primarilyfunction in the control of the germline meiotic cell cycle andadditionally in the control of mitotic cell cycle in some somaticcells. 
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Subcellular Location
Nucleus (By similarity). 
Tissue Specificity
Very high levels in testis and very low levelsin brain. Also found in myeloid Leukemia cell lines. 
Gene Ontology
GO IDGO termEvidence
GO:0005829 C:cytosol TAS:ProtInc.
GO:0015630 C:microtubule cytoskeleton IDA:LIFEdb.
GO:0005654 C:nucleoplasm TAS:Reactome.
GO:0051301 P:cell division IEA:UniProtKB-KW.
GO:0000086 P:G2/M transition of mitotic cell cycle TAS:Reactome.
GO:0007141 P:male meiosis I TAS:ProtInc.
GO:0007067 P:mitosis IEA:UniProtKB-KW.
GO:0000079 P:regulation of cyclin-dependent protein kinase activity IEA:InterPro.
GO:0000083 P:regulation of transcription involved in G1/S phase of mitotic cell cycle TAS:Reactome.
GO:0007283 P:spermatogenesis TAS:ProtInc.
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Interpro
IPR013763;    Cyclin-like.
IPR014400;    Cyclin_A/B/D/E.
IPR004367;    Cyclin_C.
IPR006671;    Cyclin_N.
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Pfam
PF02984;    Cyclin_C;    1.
PF00134;    Cyclin_N;    1.
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SMART
SM00385;    CYCLIN;    2.
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PROSITE
PS00292;    CYCLINS;    1.
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PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1    465       Cyclin-A1.
                             /FTId=PRO_0000080333.
COMPBIAS    388    391       Poly-Ala.
VAR_SEQ       1     44       Missing (in isoform 3).
                             /FTId=VSP_044257.
VAR_SEQ      38     38       Missing (in isoform 2).
                             /FTId=VSP_034392.
CONFLICT     43     47       EAMHC -> SS (in Ref. 2; AAV38384).
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Nucleotide Sequence
Length: 1743 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 465 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
CABL1HPRD 
GOT2IntAct 
ACLYIntAct 
APEX1IntAct 
ARID2HPRD 
ATXN2LIntAct 
_BioGRID 
_BioGRID 
_BioGRID 
_BioGRID 
BRCA1HPRD 
MTHFD1IntAct 
CABLES1HPRD 
CUX1BioGRID 
CAPZA1IntAct 
Mybl2BioGRID 
XRCC6HPRD 
_BioGRID 
_BioGRID 
CCNA1HPRD 
CCNA1HPRD 
CDK1HPRD 
CDK2HPRD 
CDKN1AHPRD 
CDKN1BHPRD 
MCCBioGRID 
E2F1HPRD 
RBM4BioGRID 
_HPRD 
GNB2L1HPRD 
GPS2BioGRID 
HIST1H1ABioGRID 
HIST1H2BABioGRID 
INCA1BioGRID 
KIAA1967BioGRID 
KLHDC9BioGRID 
MCM4IntAct 
MCM6HPRD 
CDC25AHPRD 
MYBL2HPRD 
Mybl2BioGRID 
CDK2deltaTBioGRID 
PROCA1HPRD 
PSMD6IntAct 
GPS2BioGRID 
CDKN1AHPRD 
CDKN1BHPRD 
RBL2HPRD 
_HPRD 
RBL1HPRD 
RBL2HPRD 
RBM4HPRD 
RB1HPRD 
SKP2BioGRID 
SP1BioGRID 
TGFB1I1BioGRID 
TRIM28IntAct 
VHLIntAct 
VPS18BioGRID 
XRCC6HPRD 
CDC20BioGRID 
CDK1BioGRID 
CDK2BioGRID 
CDKN1AIntAct 
CDKN1BBioGRID 
CDT1BioGRID 
MCCIntAct 
CUX1BioGRID 
_MINT 
E2F1BioGRID 
BRCA1BioGRID 
TUFMIntAct 
EIF3FIntAct 
EIF3IIntAct 
PTK2IntAct 
GANABIntAct 
GPS2HPRD 
INCA1BioGRID 
KIAA1967IntAct 
CSNK1DIntAct 
CSNK1EIntAct 
KLHDC9HPRD 
LARP4BIntAct 
LRPPRCIntAct 
LRRC59IntAct 
MCM2IntAct 
MCM3IntAct 
MCM4HPRD 
MCM6MINT 
MYBL2BioGRID 
CDK2deltaTBioGRID 
OATIntAct 
ORC1IntAct 
ORC2IntAct 
PPP2CBIntAct 
PARK2BioGRID 
PFASIntAct 
PAICSIntAct 
BRCA1HPRD 
Nbla10317BioGRID 
BRCA1BioGRID 
PARK2BioGRID 
PARK2BioGRID 
GPS2HPRD 
CDKN1BBioGRID 
BRCA1HPRD 
RBL2BioGRID 
_BioGRID 
RBL1BioGRID 
RBL2BioGRID 
RB1BioGRID 
SEC13IntAct 
SIC1BioGRID 
SKP2BioGRID 
STOML2IntAct 
TGFB1I1IntAct 
ACAT2IntAct 
VPS18IntAct 
XPO5IntAct 
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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