SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000534 
UniProt Accession
Theoretical PI
9.22  
Molecular Weight
27729 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
SYCP3 
Gene Synonyms/Alias
SCP3 
Protein Name
Synaptonemal complex protein 3 
Protein Synonyms/Alias
SCP-3 
Organism
Homo sapiens (Human) 
NCBI Taxonomy ID
9606 
Chromosome Location
chr:12;102122426-102133250;-1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
SYCP3 is expressed in human testis and is restricted to germ cells. Our findings, in association with those obtained in experimental animals, shows that lack of SYCP3 expression in human testis may have a negative effect on spermatogenesis and male fertility. 
The information of related literatures
1. M. Aarabi, M. H. Modarressi, H. Soltanghoraee, R. Behjati, N. Amirjannati and M. M. Akhondi (2006) Testicular expression of synaptonemal complex protein 3 (SYCP3) messenger ribonucleic acid in 110 patients with nonobstructive azoospermia. Fertil Steril 86(2): 325-31. 

Abstract
OBJECTIVE PMID: [16824523] 

2. T. Miyamoto, S. Hasuike, L. Yogev, M. R. Maduro, M. Ishikawa, H. Westphal and D. J. Lamb (2003) Azoospermia in patients heterozygous for a mutation in SYCP3. Lancet 362(9397): 1714-9. 

Abstract
BACKGROUND PMID: [14643120] 

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Figures for illustrating the function of this protein/gene
Function
Component of the transverse filaments of synaptonemalcomplexes (SCS), formed between homologous chromosomes duringmeiotic prophase. Has an essential meiotic function inspermatogenesis. May be important for testis development. 
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Subcellular Location
Nucleus (By similarity). Note=In tripartitesegments of synaptonemal complexes, irrespective of whether theseare synapsed or unsynapsed (By similarity). 
Tissue Specificity
Testis-specific. 
Gene Ontology
GO IDGO termEvidence
GO:0005634 C:nucleus IEA:UniProtKB-SubCell.
GO:0003677 F:DNA binding IEA:UniProtKB-KW.
GO:0051301 P:cell division IEA:UniProtKB-KW.
GO:0007141 P:male meiosis I NAS:UniProtKB.
GO:0035093 P:spermatogenesis, exchange of chromosomal proteins IMP:UniProtKB.
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Interpro
IPR006888;    Cor1/Xlr/Xmr.
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Pfam
PF04803;    Cor1;    1.
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SMART
PROSITE
PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1    236       Synaptonemal complex protein 3.
                             /FTId=PRO_0000229024.
COILED      139    223       Potential.
MOTIF        88     91       Nuclear localization signal (Potential).
COMPBIAS    105    232       Gln-rich.
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Nucleotide Sequence
Length: 845 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 236 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
REC8BioGRID 
SMC1ABioGRID 
SMC3BioGRID 
PABPC1HPRD 
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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