SIGNAL 1 22 Potential.
CHAIN 23 1255 Receptor tyrosine-protein kinase erbB-2.
/FTId=PRO_0000016669.
TOPO_DOM 23 652 Extracellular (Potential).
TRANSMEM 653 675 Helical; (Potential).
TOPO_DOM 676 1255 Cytoplasmic (Potential).
DOMAIN 720 987 Protein kinase.
NP_BIND 726 734 ATP (By similarity).
REGION 676 689 Nuclear localization signal.
REGION 676 689 Required for interaction with KPNB1 and
EEA1.
REGION 1195 1197 Interaction with PIK3C2B (Probable).
ACT_SITE 845 845 Proton acceptor (By similarity).
BINDING 753 753 ATP (By similarity).
MOD_RES 735 735 Phosphotyrosine.
MOD_RES 1054 1054 Phosphoserine.
MOD_RES 1139 1139 Phosphotyrosine; by autocatalysis (By
similarity).
MOD_RES 1196 1196 Phosphotyrosine (Potential).
MOD_RES 1248 1248 Phosphotyrosine; by autocatalysis.
CARBOHYD 68 68 N-linked (GlcNAc...).
CARBOHYD 124 124 N-linked (GlcNAc...) (Potential).
CARBOHYD 187 187 N-linked (GlcNAc...) (Potential).
CARBOHYD 259 259 N-linked (GlcNAc...).
CARBOHYD 530 530 N-linked (GlcNAc...).
CARBOHYD 571 571 N-linked (GlcNAc...).
CARBOHYD 629 629 N-linked (GlcNAc...) (Potential).
DISULFID 26 53
DISULFID 162 192
DISULFID 195 204
DISULFID 199 212
DISULFID 220 227
DISULFID 224 235
DISULFID 236 244
DISULFID 240 252
DISULFID 255 264
DISULFID 268 295
DISULFID 299 311
DISULFID 315 331
DISULFID 334 338
DISULFID 342 367
DISULFID 475 504
DISULFID 511 520
DISULFID 515 528
DISULFID 531 540
DISULFID 544 560
DISULFID 563 576
DISULFID 567 584
DISULFID 587 596
DISULFID 600 623
DISULFID 626 634 By similarity.
DISULFID 630 642 By similarity.
VAR_SEQ 1 686 Missing (in isoform 3).
/FTId=VSP_039250.
VAR_SEQ 1 610 Missing (in isoform 2).
/FTId=VSP_039249.
VAR_SEQ 1 23 MELAALCRWGLLLALLPPGAAST -> MPRGSWKP (in
isoform 4).
/FTId=VSP_039248.
VARIANT 452 452 W -> C (in dbSNP:rs4252633).
/FTId=VAR_016317.
VARIANT 654 654 I -> V (in allele B3; dbSNP:rs1801201).
/FTId=VAR_004077.
VARIANT 655 655 I -> V (in allele B2 and allele B3;
dbSNP:rs1136201).
/FTId=VAR_004078.
VARIANT 755 755 L -> P (in a lung adenocarcinoma sample;
somatic mutation).
/FTId=VAR_055432.
VARIANT 768 768 L -> S (in dbSNP:rs56366519).
/FTId=VAR_042097.
VARIANT 774 774 M -> MAYVM (in a lung adenocarcinoma
sample; somatic mutation).
/FTId=VAR_055433.
VARIANT 776 776 G -> S (in a gastric adenocarcinoma
sample; somatic mutation;
dbSNP:rs28933369).
/FTId=VAR_042098.
VARIANT 779 779 S -> SVGS (in a lung adenocarcinoma
sample; somatic mutation).
/FTId=VAR_055434.
VARIANT 857 857 N -> S (in an ovarian cancer sample;
somatic mutation; dbSNP:rs28933370).
/FTId=VAR_042099.
VARIANT 914 914 E -> K (in a glioblastoma sample; somatic
mutation; dbSNP:rs28933368).
/FTId=VAR_055435.
VARIANT 1170 1170 P -> A (in dbSNP:rs61552325).
/FTId=VAR_016318.
VARIANT 1216 1216 A -> D (in dbSNP:rs55943169).
/FTId=VAR_042100.
MUTAGEN 317 318 LH->AA: Reduces dimerization with ERBB3.
MUTAGEN 611 611 M->A: Prevents synthesis of isoform 2.
MUTAGEN 687 687 M->A: Prevents synthesis of isoform 3.
MUTAGEN 706 706 M->A: No effect on isoform production.
MUTAGEN 712 712 M->A: No effect on isoform production.
STRAND 25 27
HELIX 39 50
STRAND 54 58
STRAND 60 64
HELIX 72 74
STRAND 79 82
STRAND 84 88
STRAND 92 95
TURN 109 111
STRAND 112 117
TURN 130 132
STRAND 139 141
STRAND 150 156
TURN 164 166
HELIX 169 172
HELIX 175 177
STRAND 182 184
STRAND 199 202
STRAND 204 208
HELIX 209 211
STRAND 217 219
STRAND 221 223
STRAND 227 231
HELIX 232 234
STRAND 240 248
STRAND 251 260
STRAND 263 267
STRAND 271 274
TURN 276 278
STRAND 281 283
STRAND 289 291
STRAND 294 298
STRAND 303 305
STRAND 309 314
STRAND 320 323
STRAND 325 327
STRAND 329 332
STRAND 335 337
HELIX 348 352
TURN 358 360
HELIX 361 364
STRAND 368 376
HELIX 378 382
HELIX 385 387
HELIX 396 402
STRAND 405 408
STRAND 410 413
HELIX 423 425
TURN 438 440
STRAND 441 447
STRAND 463 469
HELIX 482 485
STRAND 486 488
STRAND 493 499
HELIX 501 506
TURN 507 509
HELIX 516 518
STRAND 520 524
HELIX 525 527
STRAND 528 536
STRAND 539 542
STRAND 545 551
STRAND 553 556
STRAND 559 562
STRAND 571 573
STRAND 575 580
STRAND 583 592
STRAND 595 599
STRAND 602 604
STRAND 615 617
STRAND 621 625
STRAND 628 632
STRAND 635 637
HELIX 651 678
HELIX 717 719
STRAND 720 728
STRAND 730 739
STRAND 748 755
HELIX 761 774
STRAND 785 799
HELIX 806 812
TURN 814 816
HELIX 819 838
HELIX 848 850
STRAND 851 855
STRAND 858 861
HELIX 886 888
HELIX 891 896
HELIX 901 916
TURN 922 925
HELIX 928 930
HELIX 931 936
HELIX 949 958
HELIX 963 965
HELIX 969 980
HELIX 983 986
HELIX 989 992
HELIX 1003 1008
STRAND 1140 1142
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