SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000552 
UniProt Accession
Theoretical PI
5.81  
Molecular Weight
48551 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
CCNA2 
Gene Synonyms/Alias
CCN1, CCNA 
Protein Name
Cyclin-A2 
Protein Synonyms/Alias
Cyclin-A 
Organism
Homo sapiens (Human) 
NCBI Taxonomy ID
9606 
Chromosome Location
chr:4;122737599-122745087;-1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Cyclin A is involved in both mitosis and meiosis of human spermatogenesis as it is expressed in spermatogonia and primary spermatocytes. Morphometry of human testis is intimately correlated with the testicular histopathology. 
The information of related literatures
1. A. G. Abdou, M. A. Hammam, A. G. Farag, S. Farouk and M. Fawzy (2011) Immunohistochemical expression of cyclin A in testicular biopsies of fertile and infertile men. Andrologia 43(1): 57-64. 

Abstract
Cyclin A is a member of the cyclin family of proteins, which are required for both the mitotic and meiotic divisions that characterise spermatogenesis in human and other mammalian species. The data on cyclin A expression in various human spermatogenic disorders and its relationship to the morphology of seminiferous tubules are not well clarified. This study aimed to evaluate the immunohistochemical expression of cyclin A in testicular biopsies of different spermatogenic disorders correlating with the morphology of seminiferous tubules using morphometry tools. Immunohistochemical evaluation of cyclin A was carried out on testicular biopsies obtained from 48 infertile males (nonobstructive azoospermia) and 15 normal subjects together with using semiautomatic morphometric analysis for evaluation of seminiferous tubules. Cyclin A is expressed in 100% of normal and hypospermatogenesis groups and in 80% of maturation arrest group, with complete absence in Sertoli cell only group. In positive cases, cyclin A stained the nuclei of spermatogonia and primary spermatocytes with a higher intensity of expression in normal cases compared with infertile group. Cyclin A expression was significantly associated with the different examined morphometric parameters. Cyclin A is involved in both mitosis and meiosis of human spermatogenesis as it is expressed in spermatogonia and primary spermatocytes. Morphometry of human testis is intimately correlated with the testicular histopathology. PMID: [21219384] 

Back to Top
Figures for illustrating the function of this protein/gene
Ref: A. G. Abdou, M. A. Hammam, A. G. Farag, S. Farouk and M. Fawzy (2011) Immunohistochemical expression of cyclin A in testicular biopsies of fertile and infertile men. Andrologia 43(1): 57-64. PMID: [21219384]
Ref: A. G. Abdou, M. A. Hammam, A. G. Farag, S. Farouk and M. Fawzy (2011) Immunohistochemical expression of cyclin A in testicular biopsies of fertile and infertile men. Andrologia 43(1): 57-64. PMID: [21219384]
Ref: A. G. Abdou, M. A. Hammam, A. G. Farag, S. Farouk and M. Fawzy (2011) Immunohistochemical expression of cyclin A in testicular biopsies of fertile and infertile men. Andrologia 43(1): 57-64. PMID: [21219384]
Function
Essential for the control of the cell cycle at the G1/S(start) and the G2/M (mitosis) transitions. 
Back to Top
Subcellular Location
Nucleus. Cytoplasm. Note=Cytoplasmic whenassociated with SCAPER. 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0005737 C:cytoplasm IEA:UniProtKB-SubCell.
GO:0001939 C:female pronucleus IEA:Compara.
GO:0001940 C:male pronucleus IEA:Compara.
GO:0005654 C:nucleoplasm TAS:Reactome.
GO:0051301 P:cell division IEA:UniProtKB-KW.
GO:0007067 P:mitosis IEA:UniProtKB-KW.
GO:0007095 P:mitotic cell cycle G2/M transition DNA damage checkpoint TAS:ProtInc.
GO:0045893 P:positive regulation of transcription, DNA-dependent IEA:Compara.
GO:0007265 P:Ras protein signal transduction IEP:BHF-UCL.
GO:0000079 P:regulation of cyclin-dependent protein kinase activity IEA:InterPro.
Back to Top
Interpro
IPR013763;    Cyclin-like.
IPR014400;    Cyclin_A/B/D/E.
IPR004367;    Cyclin_C.
IPR006671;    Cyclin_N.
Back to Top
Pfam
PF02984;    Cyclin_C;    1.
PF00134;    Cyclin_N;    1.
Back to Top
SMART
SM00385;    CYCLIN;    2.
Back to Top
PROSITE
PS00292;    CYCLINS;    1.
Back to Top
PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1    432       Cyclin-A2.
                             /FTId=PRO_0000080338.
MOD_RES       5      5       Phosphoserine.
MOD_RES      55     55       Phosphoserine.
VARIANT     163    163       I -> V (in dbSNP:rs769242).
                             /FTId=VAR_018819.
CONFLICT    156    156       H -> R (in Ref. 3; CAG28620).
HELIX       176    178
HELIX       179    192
HELIX       199    202
HELIX       208    224
HELIX       229    245
HELIX       250    268
STRAND      269    271
HELIX       275    281
STRAND      284    286
HELIX       288    301
TURN        302    304
HELIX       311    319
STRAND      322    324
HELIX       327    342
HELIX       344    347
HELIX       352    368
HELIX       374    380
HELIX       384    400
HELIX       401    403
HELIX       408    413
HELIX       416    418
HELIX       421    423
Back to Top
Nucleotide Sequence
Length: 1649 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 432 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
Abl1IntAct 
ADIPOR1String 
_HPRD 
CALM1BioGRID 
_BioGRID 
BRCA2HPRD 
CALM1BioGRID 
ADIPOR1String 
_BioGRID 
BRCA1HPRD 
BTG1HPRD 
CHAF1AMINT 
CDK1HPRD 
CDK2HPRD 
CDK3HPRD 
CDKN1AHPRD 
CDKN1BBioGRID 
CDKN1CBioGRID 
ITGB3BPBioGRID 
BRCA1BioGRID 
FEN1BioGRID 
HIRAHPRD 
_MINT 
CDK2deltaTBioGRID 
TP53BioGRID 
PCNABioGRID 
PGRHPRD 
BRCA1HPRD 
BRCA1BioGRID 
_BioGRID 
FEN1BioGRID 
CDKN1AHPRD 
CDKN1BBioGRID 
BTG1HPRD 
BRCA1HPRD 
RBL1HPRD 
SP1BioGRID 
SRCDIP 
UBCBioGRID 
CDC20HPRD 
CDC6HPRD 
CDK1DIP 
Cdk1IntAct 
CDK2BioGRID 
CDKN1AIntAct 
CDKN1BHPRD 
CDT1HPRD 
ITGB3BPHPRD 
CKS1BBioGRID 
DTNBP1IntAct 
_IntAct 
E2F1HPRD 
E2F3HPRD 
HIST1H4AIntAct 
HDAC1IntAct 
HERC5HPRD 
_MINT 
CDC25CHPRD 
MYBL2HPRD 
CDK2deltaTBioGRID 
ORC1BioGRID 
ORC2BioGRID 
TP53HPRD 
PTMAHPRD 
E2F3HPRD 
_HPRD 
CKS1BBioGRID 
CDKN1BHPRD 
RBL2HPRD 
ORC1LBioGRID 
_DIP 
_HPRD 
RBL1BioGRID 
RBL2HPRD 
RB1IntAct 
RPA1BioGRID 
POLR2AIntAct 
SIC1BioGRID 
SKP1HPRD 
SKP2HPRD 
SP1BioGRID 
TAF1HPRD 
UBTFHPRD 
UIMC1BioGRID 
E7MINT 
E7MINT 
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
Comments