SG ID

SG00000554 

UniProt Accession

SPAT9_HUMAN;Q9BWV2;A8K8H3;Q4G122;Q86X33;Q8NA28;  

Theoretical PI

9.53  

Molecular Weight

28740 Da  

Genbank Nucleotide ID

AY027526; AK093225; AK292338; BC032832; BC047333;  

Genbank Protein ID

AAK16746.1; BAC04101.1; BAF85027.1; AAH32832.1; AAH47333.1; 

Gene Name

SPATA9 

Gene Synonyms/Alias

 

Protein Name

Spermatogenesis-associated protein 9 

Protein Synonyms/Alias

Testis development protein NYD-SP16; 

Homo sapiens (Human) 

9606 

The putative NYD-SP16 protein may play an important role in testicular development/spermatogenesis and may be an important factor in male infertility. 

The information of related literatures

1. L. J. Cheng, J. M. Li, J. Chen, Y. H. Ge, Z. R. Yu, D. S. Han, Z. M. Zhou and J. H. Sha (2003) NYD-SP16, a novel gene associated with spermatogenesis of human testis. Biol Reprod 68(1): 190-8. 

Abstract
By hybridizing human adult testis cDNA microarrays with human adult and embryo testis cDNA probes, a novel human testis gene NYD-SP16 was identified. NYD-SP16 expression was 6.44-fold higher in adult testis than in fetal testis. NYD-SP16 contains 1595 base pairs (bp) and a 762-bp open reading frame encoding a 254-amino acid protein with 73% amino acid sequence identity with the mouse testis homologous protein. The NYD-SP16 gene was localized to human chromosome 5q14. The deduced structure of the NYD-SP16 protein contains one transmembrane domain, which was confirmed by GFP/NYD-SP16 fusion protein expression in the cytomembrane of the transfected human choriocarcinoma JAR cells, suggesting that it is a transmembrane protein. Multiple tissue distribution indicated that NYD-SP16 mRNA is highly expressed in the testes and pancreas, with little or no expression elsewhere. Further analysis of abnormal expression in infertile male patients revealed complete absence of NYD-SP16 in the testes of patients with Sertoli-cell-only syndrome and variable expression in patients with spermatogenic arrest. Homologous gene expression in mouse testis was confirmed in spermatogenic cells by in situ hybridization. The results of cDNA microarray, in situ hybridization, and semiquantitative polymerase chain reaction in mouse testis of different stages indicated that NYD-SP16 expression is developmentally regulated. These results suggest that the putative NYD-SP16 protein may play an important role in testicular development/spermatogenesis and may be an important factor in male infertility. PMID: [12493713] 

Figures for illustrating the function of this protein/gene

Function

May play a role in testiculardevelopment/spermatogenesis and may be an important factor in maleinfertility. 

Subcellular Location

Membrane; Single-pass membrane protein(Potential). 

Tissue Specificity

Highly expressed in testes and pancreas. Lowlevels found in the heart, lungs, and brain. Very low expressiondetected in the placenta. No expression seen in skeletal muscle,liver, kidney, thymus, small intestine, colons, spleen,leukocytes, prostate gland, and ovary. In the adult testes,expression was about 6.44-fold higher than in the embryo testes.No expression in testes of patients with Sertoli-cell-onlysyndrome. In patients with arrest at spermatogonium and primaryspermatocyte stages, no expression was detected. In patients witharrest at the spermatid stage, expression level was weak orabsent. Variable expression was seen in patients withspermatogenic arrest.-----------------------------------------------------------------------Copyrighted by the UniProt Consortium, see http://www.uniprot.org/termsDistributed under the Creative Commons Attribution-NoDerivs License----------------------------------------------------------------------- 

Gene Ontology

GO ID	GO term	Evidence
GO:0016021	C:integral to membrane	IEA:UniProtKB-KW.
GO:0030154	P:cell differentiation	IEA:UniProtKB-KW.
GO:0007275	P:multicellular organismal development	IEA:UniProtKB-KW.
GO:0007283	P:spermatogenesis	IEA:UniProtKB-KW.

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: 1595 bp   Go to nucleotide: FASTA

Protein Sequence

Length: 254 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

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Other Protein-Protein interaction resources

String database  

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Gene Symbol

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