SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000563 
UniProt Accession
Theoretical PI
6.07  
Molecular Weight
480410 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
ANK3 
Gene Synonyms/Alias
 
Protein Name
Ankyrin-3 
Protein Synonyms/Alias
ANK-3 Ankyrin-G; 
Organism
Homo sapiens (Human) 
NCBI Taxonomy ID
9606 
Chromosome Location
chr:10;61788159-62493248;-1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
ASB-4 plays pivotal roles in mammalian testis development and spermatogenesis. 
The information of related literatures
1. S. K. Kim, S. Y. Rhim, M. R. Lee, J. S. Kim, H. J. Kim, D. R. Lee and K. S. Kim (2008) Stage-specific expression of ankyrin and SOCS box protein-4 (Asb-4) during spermatogenesis. Mol Cells 25(2): 317-21. 

Abstract
Members of the large family of Asb proteins are ubiquitously expressed in mammalian tissues; however, the roles of individual Asb and their function in the developmental testes have not been reported. In this report, we isolated a murine Asb4 from mouse testis. Northern blot analysis revealed that mAsb-4 was expressed only in testes and produced in a stage-specific manner during spermatogenesis. It was expressed in murine testes beginning in the fourth week after birth and extending into adulthood. Pachytene spermatocytes had the highest level of expression. Interestingly, the human homologue of mAsb-4, ASB-4 (hASB-4) was also expressed in human testis. These results suggest that ASB-4 plays pivotal roles in mammalian testis development and spermatogenesis. PMID: [18414003] 

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Figures for illustrating the function of this protein/gene
Function
Membrane-cytoskeleton linker. May participate in themaintenance/targeting of ion channels and cell adhesion moleculesat the nodes of Ranvier and axonal initial segments. 
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Subcellular Location
Cytoplasm, cytoskeleton. 
Tissue Specificity
Expressed in brain, neurons and other tissues. 
Gene Ontology
GO IDGO termEvidence
GO:0043194 C:axon initial segment ISS:BHF-UCL.
GO:0016323 C:basolateral plasma membrane IDA:UniProtKB.
GO:0009986 C:cell surface ISS:BHF-UCL.
GO:0043034 C:costamere TAS:BHF-UCL.
GO:0014704 C:intercalated disc ISS:BHF-UCL.
GO:0016328 C:lateral plasma membrane IDA:BHF-UCL.
GO:0033268 C:node of Ranvier ISS:BHF-UCL.
GO:0014731 C:spectrin-associated cytoskeleton ISS:BHF-UCL.
GO:0030315 C:T-tubule ISS:BHF-UCL.
GO:0005200 F:structural constituent of cytoskeleton IMP:BHF-UCL.
GO:0007409 P:axonogenesis ISS:BHF-UCL.
GO:0000281 P:cytokinesis after mitosis IMP:BHF-UCL.
GO:0043001 P:Golgi to plasma membrane protein transport IMP:BHF-UCL.
GO:0072660 P:maintenance of protein location in plasma membrane IGI:BHF-UCL.
GO:0071709 P:membrane assembly IMP:BHF-UCL.
GO:0010628 P:positive regulation of gene expression ISS:BHF-UCL.
GO:1900827 P:positive regulation of membrane depolarization involved in regulation of cardiac muscle cell action potential ISS:BHF-UCL.
GO:0045838 P:positive regulation of membrane potential ISS:BHF-UCL.
GO:2000651 P:positive regulation of sodium ion transmembrane transporter activity ISS:BHF-UCL.
GO:0010765 P:positive regulation of sodium ion transport ISS:BHF-UCL.
GO:0072661 P:protein targeting to plasma membrane IMP:BHF-UCL.
GO:0019228 P:regulation of action potential in neuron ISS:BHF-UCL.
GO:0043266 P:regulation of potassium ion transport ISS:BHF-UCL.
GO:0007165 P:signal transduction IEA:InterPro.
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Interpro
IPR002110;    Ankyrin_rpt.
IPR020683;    Ankyrin_rpt-contain_dom.
IPR000488;    Death.
IPR011029;    DEATH-like.
IPR000906;    ZU5.
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Pfam
PF00023;    Ank;    1.
PF12796;    Ank_2;    7.
PF00531;    Death;    1.
PF00791;    ZU5;    1.
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SMART
SM00248;    ANK;    22.
SM00005;    DEATH;    1.
SM00218;    ZU5;    1.
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PROSITE
PS50297;    ANK_REP_REGION;    1.
PS50088;    ANK_REPEAT;    21.
PS50017;    DEATH_DOMAIN;    1.
PS51145;    ZU5;    1.
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PRINTS
PR01415;    ANKYRIN.;   
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Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1   4377       Ankyrin-3.
                             /FTId=PRO_0000066886.
REPEAT       73    102       ANK 1.
REPEAT      106    135       ANK 2.
REPEAT      139    168       ANK 3.
REPEAT      172    201       ANK 4.
REPEAT      203    230       ANK 5.
REPEAT      234    263       ANK 6.
REPEAT      267    296       ANK 7.
REPEAT      300    329       ANK 8.
REPEAT      333    362       ANK 9.
REPEAT      366    395       ANK 10.
REPEAT      399    428       ANK 11.
REPEAT      432    461       ANK 12.
REPEAT      465    494       ANK 13.
REPEAT      498    527       ANK 14.
REPEAT      531    560       ANK 15.
REPEAT      564    593       ANK 16.
REPEAT      597    626       ANK 17.
REPEAT      630    659       ANK 18.
REPEAT      663    692       ANK 19.
REPEAT      696    725       ANK 20.
REPEAT      729    758       ANK 21.
REPEAT      762    791       ANK 22.
REPEAT      795    825       ANK 23.
DOMAIN      982   1107       ZU5 1.
DOMAIN     1108   1272       ZU5 2.
DOMAIN     4090   4174       Death.
REGION     1273   1407       UPA domain (By similarity).
COMPBIAS   1519   1898       Ser-rich.
COMPBIAS   2247   2250       Poly-Thr.
COMPBIAS   2393   2396       Poly-Glu.
COMPBIAS   3205   3211       Poly-Glu.
COMPBIAS   3255   3259       Poly-Pro.
COMPBIAS   3482   3487       Poly-Ser.
COMPBIAS   3785   3791       Poly-Asn.
COMPBIAS   3957   3981       Thr-rich.
MOD_RES     533    533       Phosphotyrosine.
MOD_RES    1459   1459       Phosphoserine.
MOD_RES    4298   4298       Phosphoserine.
CROSSLNK   4338   4338       Glycyl lysine isopeptide (Lys-Gly)
                             (interchain with G-Cter in ubiquitin).
VARIANT    2318   2318       K -> R (in dbSNP:rs59021407).
                             /FTId=VAR_061013.
VARIANT    2885   2885       H -> Q (in dbSNP:rs11599164).
                             /FTId=VAR_059115.
VARIANT    2996   2996       Q -> H (in dbSNP:rs41274672).
                             /FTId=VAR_061014.
VARIANT    3117   3117       I -> V (in dbSNP:rs28932171).
                             /FTId=VAR_059116.
VARIANT    3123   3123       K -> R (in dbSNP:rs10821668).
                             /FTId=VAR_059117.
VARIANT    4257   4257       I -> V (in dbSNP:rs12261793).
                             /FTId=VAR_054333.
CONFLICT   1036   1043       MVEGEGLA -> HGERRGIS (in Ref. 1;
                             AAA64834).
CONFLICT   1418   1418       P -> R (in Ref. 1; AAA64834).
CONFLICT   1574   1574       F -> L (in Ref. 1; AAA64834).
CONFLICT   1685   1685       A -> R (in Ref. 1; AAA64834).
CONFLICT   1726   1726       P -> A (in Ref. 1; AAA64834).
CONFLICT   2062   2063       ER -> GG (in Ref. 1; AAA64834).
CONFLICT   2146   2146       S -> T (in Ref. 1; AAA64834).
CONFLICT   3919   3919       H -> P (in Ref. 1; AAA64834).
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Nucleotide Sequence
Length: 14770 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 4377 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
Other Protein-Protein interaction resources
String database  
View Microarray data
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