SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000570 
UniProt Accession
Theoretical PI
5.54  
Molecular Weight
43923 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
ART3 
Gene Synonyms/Alias
TMART 
Protein Name
Ecto-ADP-ribosyltransferase 3 
Protein Synonyms/Alias
EC=2.4.2.31 ADP-ribosyltransferase C2 and C3 toxin-like 3;ARTC3 Mono(ADP-ribosyl)transferase 3; NAD(P)(+)--arginine ADP-ribosyltransferase 3;Flags: Precursor 
Organism
Homo sapiens (Human) 
NCBI Taxonomy ID
9606 
Chromosome Location
chr:4;76932337-77033955;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
ART3 protein is expressed in testes in particular on spermatocytes, indicating that ART3 exerts a specific function only required at a particular stage of spermatogenesis. 
The information of related literatures
1. M. Friedrich, A. Grahnert, U. Paasch, A. Tannapfel, F. Koch-Nolte and S. Hauschildt (2006) Expression of toxin-related human mono-ADP-ribosyltransferase 3 in human testes. Asian J Androl 8(3): 281-7. 

Abstract
AIM PMID: [16625277] 

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Figures for illustrating the function of this protein/gene
Function
 
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Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor. 
Tissue Specificity
Testis specific. 
Gene Ontology
GO IDGO termEvidence
GO:0031225 C:anchored to membrane IEA:UniProtKB-KW.
GO:0005887 C:integral to plasma membrane TAS:ProtInc.
GO:0003956 F:NAD(P)+-protein-arginine ADP-ribosyltransferase activity IEA:EC.
GO:0003950 F:NAD+ ADP-ribosyltransferase activity TAS:ProtInc.
GO:0006471 P:protein ADP-ribosylation TAS:ProtInc.
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Interpro
Pfam
PF01129;    ART;    1.
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SMART
PROSITE
PS01291;    ART;    1.
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PRINTS
PR00970;    RIBTRNSFRASE.;   
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Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
SIGNAL        1     26       Potential.
CHAIN        27    362       Ecto-ADP-ribosyltransferase 3.
                             /FTId=PRO_0000019325.
PROPEP      363    389       Removed in mature form (By similarity).
                             /FTId=PRO_0000019326.
REPEAT      283    292       1.
REPEAT      293    302       2.
REPEAT      303    312       3.
REGION      283    312       3 X 10 AA tandem repeats of [GS]-E-K-N-
                             [QW]-K-L-E-D-H.
ACT_SITE    229    229       By similarity.
BINDING     101    101       NAD (By similarity).
BINDING     163    163       NAD (By similarity).
LIPID       362    362       GPI-anchor amidated serine (By
                             similarity).
CARBOHYD    248    248       N-linked (GlcNAc...) (Potential).
CARBOHYD    346    346       O-linked (GalNAc...).
DISULFID     43    256       By similarity.
VAR_SEQ     324    346       GMKIPEPFPLPEDKSQGNINNPT -> A (in isoform
                             1).
                             /FTId=VSP_003375.
VAR_SEQ     324    334       Missing (in isoform 2).
                             /FTId=VSP_003374.
VARIANT     363    363       S -> L (in dbSNP:rs1128864).
                             /FTId=VAR_060072.
CONFLICT    357    357       S -> C (in Ref. 2; CAA65096).
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Nucleotide Sequence
Length: 1419 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 389 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data
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