SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000573 
UniProt Accession
Theoretical PI
6.18  
Molecular Weight
124733 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
NLRP14 
Gene Synonyms/Alias
NALP14, NOD5 
Protein Name
NACHT, LRR and PYD domains-containing protein 14 
Protein Synonyms/Alias
Nucleotide-binding oligomerization domain protein 5; 
Organism
Homo sapiens (Human) 
NCBI Taxonomy ID
9606 
Chromosome Location
chr:11;7041677-7092539;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
NALP14 has a function in spermatogenesis and that mutations in this gene might cause spermatogenic failure. 
The information of related literatures
1. G. H. Westerveld, C. M. Korver, A. M. van Pelt, N. J. Leschot, F. van der Veen, S. Repping and M. P. Lombardi (2006) Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure. Hum Reprod 21(12): 3178-84. 

Abstract
BACKGROUND PMID: [16931801] 

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Figures for illustrating the function of this protein/gene
Ref: G. H. Westerveld, C. M. Korver, A. M. van Pelt, N. J. Leschot, F. van der Veen, S. Repping and M. P. Lombardi (2006) Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure. Hum Reprod 21(12): 3178-84. PMID: [16931801]
Function
May be involved in inflammation and spermatogenesis. 
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Subcellular Location
 
Tissue Specificity
Testis-specific. 
Gene Ontology
GO IDGO termEvidence
GO:0005524 F:ATP binding IEA:UniProtKB-KW.
GO:0030154 P:cell differentiation IEA:UniProtKB-KW.
GO:0007275 P:multicellular organismal development IEA:UniProtKB-KW.
GO:0007283 P:spermatogenesis IMP:UniProtKB.
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Interpro
IPR004020;    DAPIN.
IPR011029;    DEATH-like.
IPR007111;    NACHT_NTPase.
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Pfam
PF02758;    PYRIN;    1.
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SMART
PROSITE
PS50824;    DAPIN;    1.
PS50837;    NACHT;    1.
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PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1   1093       NACHT, LRR and PYD domains-containing
                             protein 14.
                             /FTId=PRO_0000080901.
DOMAIN        1     97       DAPIN.
DOMAIN      177    499       NACHT.
REPEAT      730    750       LRR 1.
REPEAT      759    780       LRR 2.
REPEAT      787    807       LRR 3.
REPEAT      816    836       LRR 4.
REPEAT      844    864       LRR 5.
REPEAT      873    894       LRR 6.
REPEAT      901    921       LRR 7.
REPEAT      930    951       LRR 8.
REPEAT      958    978       LRR 9.
REPEAT      987   1008       LRR 10.
REPEAT     1015   1035       LRR 11.
NP_BIND     183    190       ATP (Potential).
VARIANT      21     21       E -> K (in dbSNP:rs11041150).
                             /FTId=VAR_053622.
VARIANT      48     48       N -> T (in dbSNP:rs12801277).
                             /FTId=VAR_031932.
VARIANT      55     55       R -> E (requires 2 nucleotide
                             substitutions).
                             /FTId=VAR_031933.
VARIANT      86     86       D -> V (associated with spermatogenic
                             failure).
                             /FTId=VAR_031934.
VARIANT      92     92       K -> R (in dbSNP:rs16921697).
                             /FTId=VAR_031935.
VARIANT      98     98       S -> L.
                             /FTId=VAR_031936.
VARIANT     375    375       A -> T (associated with spermatogenic
                             failure).
                             /FTId=VAR_031937.
VARIANT     397    397       T -> I.
                             /FTId=VAR_031938.
VARIANT     441    441       V -> M.
                             /FTId=VAR_031939.
VARIANT     511    511       L -> F (in dbSNP:rs11041151).
                             /FTId=VAR_053623.
VARIANT     522    522       D -> Q (associated with spermatogenic
                             failure; requires 2 nucleotide
                             substitutions).
                             /FTId=VAR_031940.
VARIANT     779    779       S -> C (in a breast cancer sample;
                             somatic mutation).
                             /FTId=VAR_036387.
VARIANT     808    808       E -> K (in dbSNP:rs10839708).
                             /FTId=VAR_024180.
VARIANT     951    951       S -> T.
                             /FTId=VAR_031941.
VARIANT     954    954       L -> S.
                             /FTId=VAR_031942.
VARIANT    1010   1010       L -> F (in dbSNP:rs17280682).
                             /FTId=VAR_031943.
VARIANT    1019   1019       M -> I (associated with spermatogenic
                             failure).
                             /FTId=VAR_031944.
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Nucleotide Sequence
Length: 3282 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 1093 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data
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