SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000574 
UniProt Accession
Theoretical PI
8.52  
Molecular Weight
37717 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
CD1D 
Gene Synonyms/Alias
 
Protein Name
Antigen-presenting glycoprotein CD1d 
Protein Synonyms/Alias
R3G1; CD_antigen=CD1d;Flags: Precursor 
Organism
Homo sapiens (Human) 
NCBI Taxonomy ID
9606 
Chromosome Location
chr:1;158149737-158154686;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
This preliminary study displayed testicular infertility-related changes in CD1d expression. The ultrastructural changes associated with with normal and abnormal spermatogenesis are open for further investigations.  
The information of related literatures
1. M. A. Adly and M. R. Abdelwahed Hussein (2011) Expression of CD1d protein in human testis showing normal and abnormal spermatogenesis. Ultrastruct Pathol 35(3): 124-9. 

Abstract
CD1d is a member of CD1 family of transmembrane glycoproteins, which represent antigen-presenting molecules. Immunofluorescent staining methods were utilized to examine expression pattern of CD1d in human testicular specimens. In testis showing normal spermatogenesis, a strong CD1d cytoplasmic expression was seen the Sertoli cells, spermatogonia, and Leydig cells. A moderate expression was observed in the spermatocytes. In testes showing maturation arrest, CD1d expression was strong in the Sertoli cells and weak in spermatogonia and spermatocytes compared to testis with normal spermatogenesis. In Sertoli cell only syndrome, CD1d expression was strong in the Sertoli and Leydig cells. This preliminary study displayed testicular infertility-related changes in CD1d expression. The ultrastructural changes associated with with normal and abnormal spermatogenesis are open for further investigations. PMID: [21323421] 

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Figures for illustrating the function of this protein/gene
Function
Antigen-presenting protein that binds self and non-selfglycolipids and presents them to T-cell receptors on naturalkiller T-cells. 
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Subcellular Location
Cell membrane; Single-pass type I membraneprotein. Endosome membrane. Lysosome membrane. Note=Subject tointracellular trafficking between the cell membrane, endosomes andlysosomes. 
Tissue Specificity
Expressed on cortical thymocytes, on certainT-cell leukemias, and in various other tissues. 
Gene Ontology
GO IDGO termEvidence
GO:0009986 C:cell surface IDA:BHF-UCL.
GO:0005737 C:cytoplasm IDA:BHF-UCL.
GO:0010008 C:endosome membrane IEA:UniProtKB-SubCell.
GO:0005887 C:integral to plasma membrane TAS:UniProtKB.
GO:0005765 C:lysosomal membrane IEA:UniProtKB-SubCell.
GO:0043499 F:eukaryotic cell surface binding IDA:BHF-UCL.
GO:0030884 F:exogenous lipid antigen binding IDA:UniProtKB.
GO:0004872 F:receptor activity IC:UniProtKB.
GO:0048006 P:antigen processing and presentation, endogenous lipid antigen via MHC class Ib IDA:UniProtKB.
GO:0016045 P:detection of bacterium TAS:UniProtKB.
GO:0034113 P:heterotypic cell-cell adhesion TAS:BHF-UCL.
GO:0045087 P:innate immune response IEA:UniProtKB-KW.
GO:0045089 P:positive regulation of innate immune response TAS:UniProtKB.
GO:0042102 P:positive regulation of T cell proliferation IDA:BHF-UCL.
GO:0045058 P:T cell selection TAS:UniProtKB.
GO:0019048 P:virus-host interaction IEA:UniProtKB-KW.
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Interpro
IPR007110;    Ig-like.
IPR003597;    Ig_C1-set.
IPR011161;    MHC_I-like_Ag-recog.
IPR011162;    MHC_I/II-like_Ag-recog.
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Pfam
PF07654;    C1-set;    1.
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SMART
SM00407;    IGc1;    1.
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PROSITE
PS50835;    IG_LIKE;    1.
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PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
SIGNAL        1     19       By similarity.
CHAIN        20    335       Antigen-presenting glycoprotein CD1d.
                             /FTId=PRO_0000014581.
TOPO_DOM     20    301       Extracellular (Potential).
TRANSMEM    302    322       Helical; (Potential).
TOPO_DOM    323    335       Cytoplasmic (Potential).
DOMAIN      185    292       Ig-like.
MOTIF       331    334       Internalization signal.
BINDING      98     98       Glycolipid.
BINDING     169    169       Glycolipid.
BINDING     172    172       Glycolipid.
CARBOHYD     38     38       N-linked (GlcNAc...).
CARBOHYD     60     60       N-linked (GlcNAc...).
CARBOHYD    126    126       N-linked (GlcNAc...) (Potential).
CARBOHYD    181    181       N-linked (GlcNAc...) (Potential).
DISULFID    120    184
DISULFID    224    279
VARIANT      64     64       T -> S.
                             /FTId=VAR_010211.
MUTAGEN     331    331       Y->A: Strongly reduced internalization.
MUTAGEN     334    334       V->A: Strongly reduced internalization.
STRAND       28     38
STRAND       41     50
STRAND       53     58
STRAND       63     67
TURN         70     75
HELIX        78    105
STRAND      112    122
STRAND      124    126
STRAND      128    136
STRAND      139    145
STRAND      148    151
HELIX       158    166
HELIX       170    181
HELIX       183    194
HELIX       196    199
STRAND      206    211
STRAND      216    232
STRAND      235    240
STRAND      241    243
STRAND      249    255
STRAND      261    272
STRAND      278    282
TURN        284    287
STRAND      291    294
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Nucleotide Sequence
Length: 762 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 335 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
B2MHPRD 
CALRHPRD 
CANXHPRD 
CD74HPRD 
P4HTMBioGRID 
PTPRCHPRD 
PTPRCBioGRID 
P4HBHPRD 
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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