SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000577 
UniProt Accession
Theoretical PI
8.8  
Molecular Weight
54542 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
ZNF230 
Gene Synonyms/Alias
FDZF2 
Protein Name
Zinc finger protein 230 
Protein Synonyms/Alias
Zinc finger protein FDZF2; 
Organism
Homo sapiens (Human) 
NCBI Taxonomy ID
9606 
Chromosome Location
chr:19;44507077-44518072;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
The lack of detectable ZNF230 expression in azoospermic patients by reverse transcriptase-mediated PCR analysis is interpreted to mean that this gene is involved in maintaining normal human male fertility. 
The information of related literatures
1. S. Zhang, W. Qiu, H. Wu, G. Zhang, M. Huang, C. Xiao, J. Yang, C. Kamp, X. Huang, K. Huellen, Y. Yue, A. Pan, R. Lebo, A. Milunsky and P. H. Vogt (2001) The shorter zinc finger protein ZNF230 gene message is transcribed in fertile male testes and may be related to human spermatogenesis. Biochem J 359(Pt 3): 721-7. 

Abstract
The zinc finger gene family represents one of the largest in the mammalian genome, with several of these genes reported to be involved in spermatogenesis. A newly discovered gene has been identified that is expressed abundantly in the testicular tissue of fertile men as determined by mRNA differential display. The gene encodes a C(3)HC(4)-type zinc finger protein motif (ring finger motif) consistent with a role in pre-meiotic or post-meiotic sperm development. The gene was named ZNF230 and mapped to the short arm of chromosome 11 (11p15). ZNF230 has two transcripts, of 1 kb and 4.4 kb in length. The shorter 1 kb transcript was only detected in testicular tissue whereas the longer 4.4 kb transcript was not detected in testis but was found in several other tissues. The lack of detectable ZNF230 expression in azoospermic patients by reverse transcriptase-mediated PCR analysis is interpreted to mean that this gene is involved in maintaining normal human male fertility. PMID: [11672448] 

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Figures for illustrating the function of this protein/gene
Function
May be involved in transcriptional regulation. 
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Subcellular Location
Nucleus (Probable). 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0005634 C:nucleus IEA:UniProtKB-SubCell.
GO:0003677 F:DNA binding IEA:UniProtKB-KW.
GO:0008270 F:zinc ion binding IEA:InterPro.
GO:0006355 P:regulation of transcription, DNA-dependent IEA:UniProtKB-KW.
GO:0006351 P:transcription, DNA-dependent IEA:UniProtKB-KW.
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Interpro
IPR001909;    Krueppel-associated_box.
IPR007087;    Znf_C2H2.
IPR015880;    Znf_C2H2-like.
IPR013087;    Znf_C2H2/integrase_DNA-bd.
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Pfam
PF01352;    KRAB;    1.
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SMART
SM00349;    KRAB;    1.
SM00355;    ZnF_C2H2;    8.
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PROSITE
PS50805;    KRAB;    1.
PS00028;    ZINC_FINGER_C2H2_1;    7.
PS50157;    ZINC_FINGER_C2H2_2;    10.
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PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1    474       Zinc finger protein 230.
                             /FTId=PRO_0000047471.
DOMAIN        8     76       KRAB.
ZN_FING     168    190       C2H2-type 1.
ZN_FING     196    218       C2H2-type 2.
ZN_FING     224    246       C2H2-type 3.
ZN_FING     252    274       C2H2-type 4.
ZN_FING     280    302       C2H2-type 5.
ZN_FING     308    330       C2H2-type 6.
ZN_FING     336    358       C2H2-type 7.
ZN_FING     364    386       C2H2-type 8.
ZN_FING     392    414       C2H2-type 9.
ZN_FING     420    442       C2H2-type 10; atypical.
REGION       80    167       KRNB.
VARIANT     310    310       S -> C (in dbSNP:rs1060877).
                             /FTId=VAR_030534.
VARIANT     434    434       F -> Y (in dbSNP:rs6413542).
                             /FTId=VAR_030535.
VARIANT     441    441       D -> E (in dbSNP:rs12753).
                             /FTId=VAR_014827.
CONFLICT     26     26       D -> H (in Ref. 1; AAB62180).
CONFLICT     92     92       C -> V (in Ref. 1; AAB62180).
CONFLICT    201    201       R -> C (in Ref. 1; AAB62180).
CONFLICT    214    214       R -> H (in Ref. 1; AAB62180).
CONFLICT    220    220       G -> R (in Ref. 1; AAB62180).
CONFLICT    265    266       FQ -> LK (in Ref. 1; AAB62180).
CONFLICT    280    280       F -> S (in Ref. 1; AAB62180).
CONFLICT    299    299       C -> Y (in Ref. 1; AAB62180).
CONFLICT    308    310       YKS -> SKC (in Ref. 1; AAB62180).
CONFLICT    383    385       QRV -> PEG (in Ref. 1; AAB62180).
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Nucleotide Sequence
Length: 1838 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 474 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
NDEL1IntAct 
ezrAIntAct 
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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