SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000580 
UniProt Accession
Theoretical PI
5.54  
Molecular Weight
113415 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
NLRP4 
Gene Synonyms/Alias
NALP4, PAN2, PYPAF4, RNH2 
Protein Name
NACHT, LRR and PYD domains-containing protein 4 
Protein Synonyms/Alias
Cancer/testis antigen 58;CT58 PAAD and NACHT-containing protein 2; PYRIN and NACHT-containing protein 2; PYRIN-containing APAF1-like protein 4; Ribonuclease inhibitor 2; 
Organism
Homo sapiens (Human) 
NCBI Taxonomy ID
9606 
Chromosome Location
chr:19;56347944-56393218;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
The human Rnh2 gene may also play critical roles in human spermatogenesis. 
The information of related literatures
1. T. Miyamoto and S. Hasuike (2002) Isolation and expression analysis of the human RNH2 gene encoding ribonuclease inhibitor 2. J Assist Reprod Genet 19(8): 394-7. 

Abstract
Ribonuclease inhibitor 1 (RI-1) is a cytoplasmic protein that inhibits a variety of pancreatic-type mammalian Rnases by forming a very tight, reversible 1 PMID: [12182447] 

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Figures for illustrating the function of this protein/gene
Function
May be involved in inflammation. Acts as a negativeregulator of the type I interferon signaling pathway by serving asan adapter to promote DTX4-mediated ubiquitination of activatedTBK1, and its subsequent degradation. 
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Subcellular Location
 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0005524 F:ATP binding IEA:UniProtKB-KW.
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Interpro
IPR004020;    DAPIN.
IPR011029;    DEATH-like.
IPR007111;    NACHT_NTPase.
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Pfam
PF02758;    PYRIN;    1.
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SMART
PROSITE
PS50824;    DAPIN;    1.
PS50837;    NACHT;    1.
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PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1    994       NACHT, LRR and PYD domains-containing
                             protein 4.
                             /FTId=PRO_0000080889.
DOMAIN        1     94       DAPIN.
DOMAIN      149    472       NACHT.
REPEAT      637    660       LRR 1.
REPEAT      698    721       LRR 2.
REPEAT      722    745       LRR 3.
REPEAT      750    777       LRR 4.
REPEAT      806    833       LRR 5.
REPEAT      863    886       LRR 6.
REPEAT      920    943       LRR 7.
REPEAT      949    972       LRR 8.
NP_BIND     155    162       ATP (Potential).
VAR_SEQ       1    435       Missing (in isoform 2).
                             /FTId=VSP_044006.
VAR_SEQ       1     93       MAASFFSDFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQ
                             IPWTEVKKASREELANLLIKHYEEQQAWNITLRIFQKMDRK
                             DLCMKVMRERT -> MQECLTLWVFSPLALTDS (in
                             isoform 3).
                             /FTId=VSP_003916.
VAR_SEQ     731    786       Missing (in isoform 2).
                             /FTId=VSP_044007.
VARIANT     144    144       A -> T (in dbSNP:rs441827).
                             /FTId=VAR_024179.
VARIANT     383    383       E -> D (in dbSNP:rs17857373).
                             /FTId=VAR_024827.
VARIANT     390    390       P -> Q (in dbSNP:rs17857374).
                             /FTId=VAR_024828.
VARIANT     708    708       R -> H (in dbSNP:rs12462372).
                             /FTId=VAR_032764.
VARIANT     774    774       L -> M (in dbSNP:rs17854614).
                             /FTId=VAR_024829.
VARIANT     925    925       Q -> L (in dbSNP:rs302453).
                             /FTId=VAR_020007.
CONFLICT     55     55       L -> P (in Ref. 4; AAL88672).
CONFLICT     99     99       Y -> H (in Ref. 4; AAL88672).
CONFLICT    177    177       I -> T (in Ref. 4; AAL88672).
CONFLICT    209    209       W -> R (in Ref. 4; AAL88672).
CONFLICT    296    296       I -> V (in Ref. 4; AAL88672).
CONFLICT    720    720       Y -> C (in Ref. 4; AAL88672).
CONFLICT    957    957       L -> P (in Ref. 4; AAL88672).
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Nucleotide Sequence
Length: 3333 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 994 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
CHUKBioGRID 
CHUKHPRD 
NLRC4HPRD 
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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