SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000585 
UniProt Accession
Theoretical PI
5.53  
Molecular Weight
94512 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
HSPA4L 
Gene Synonyms/Alias
APG1, OSP94 
Protein Name
Heat shock 70 kDa protein 4L 
Protein Synonyms/Alias
Heat shock 70-related protein APG-1; Osmotic stress protein 94; 
Organism
Homo sapiens (Human) 
NCBI Taxonomy ID
9606 
Chromosome Location
chr:4;128702976-128755226;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Apg-1 is developmentally expressed in human testicular germ cells and sperm, suggesting its role in spermatogenesis and fertilization. Identification of substrates for Apg-1 chaperone activity will help elucidate its function. 
The information of related literatures
1. K. Nonoguchi, H. Tokuchi, H. Okuno, H. Watanabe, H. Egawa, K. Saito, O. Ogawa and J. Fujita (2001) Expression of Apg-1, a member of the Hsp110 family, in the human testis and sperm. Int J Urol 8(6): 308-14. 

Abstract
BACKGROUND PMID: [11389747] 

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Figures for illustrating the function of this protein/gene
Function
Possesses chaperone activity in vitro where it inhibitsaggregation of citrate synthase (By similarity). 
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Subcellular Location
Cytoplasm (By similarity). Nucleus (Bysimilarity). Note=May translocate to the nucleus after heat shock(By similarity). 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0005737 C:cytoplasm ISS:UniProtKB.
GO:0005634 C:nucleus ISS:UniProtKB.
GO:0005524 F:ATP binding ISS:UniProtKB.
GO:0006457 P:protein folding ISS:UniProtKB.
GO:0006986 P:response to unfolded protein ISS:UniProtKB.
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Interpro
IPR018181;    Heat_shock_70_CS.
IPR013126;    Hsp_70_fam.
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Pfam
PF00012;    HSP70;    2.
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SMART
PROSITE
PS00297;    HSP70_1;    FALSE_NEG.
PS00329;    HSP70_2;    FALSE_NEG.
PS01036;    HSP70_3;    1.
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PRINTS
PR00301;    HEATSHOCK70.;   
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Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1    839       Heat shock 70 kDa protein 4L.
                             /FTId=PRO_0000078280.
MOD_RES      74     74       Phosphoserine (By similarity).
MOD_RES     272    272       N6-acetyllysine.
MOD_RES     571    571       Phosphothreonine.
MOD_RES     761    761       Phosphothreonine.
VARIANT     211    211       L -> S (in dbSNP:rs1380154).
                             /FTId=VAR_025405.
VARIANT     216    216       N -> T (in dbSNP:rs12507229).
                             /FTId=VAR_031214.
VARIANT     601    601       I -> T (in dbSNP:rs35518193).
                             /FTId=VAR_055966.
CONFLICT    806    806       H -> R (in Ref. 1; BAA75063).
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Nucleotide Sequence
Length: 3068 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 839 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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