SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000591 
UniProt Accession
Theoretical PI
-  
Molecular Weight
66394 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
POTED 
Gene Synonyms/Alias
A26B3, ANKRD21, POTE 
Protein Name
POTE ankyrin domain family member D 
Protein Synonyms/Alias
ANKRD26-like family B member 3; Ankyrin repeat domain-containing protein 21; Prostate, ovary, testis-expressed protein;Protein POTE 
Organism
Homo sapiens (Human) 
NCBI Taxonomy ID
9606 
Chromosome Location
chr:21;14982498-15013906;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
The POTE gene family is composed of 13 highly homologous paralogs preferentially expressed in prostate, ovary, testis, and placenta. We produced 10 monoclonal antibodies (MAbs) against three representative POTE paralogs. 
The information of related literatures
1. T. Ise, S. Das, S. Nagata, H. Maeda, Y. Lee, M. Onda, M. R. Anver, T. K. Bera and I. Pastan (2008) Expression of POTE protein in human testis detected by novel monoclonal antibodies. Biochem Biophys Res Commun 365(4): 603-8. 

Abstract
The POTE gene family is composed of 13 highly homologous paralogs preferentially expressed in prostate, ovary, testis, and placenta. We produced 10 monoclonal antibodies (MAbs) against three representative POTE paralogs PMID: [17996727] 

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Figures for illustrating the function of this protein/gene
Function
 
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Subcellular Location
Cell membrane; Peripheral membrane protein. 
Tissue Specificity
Expressed in prostate, ovary, testis, placentaand prostate cancer cell lines. Localizes to basal and terminalprostate epithelial cells. 
Gene Ontology
GO IDGO termEvidence
GO:0005886 C:plasma membrane IEA:UniProtKB-SubCell.
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Interpro
IPR002110;    Ankyrin_rpt.
IPR020683;    Ankyrin_rpt-contain_dom.
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Pfam
PF12796;    Ank_2;    2.
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SMART
SM00248;    ANK;    6.
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PROSITE
PS50297;    ANK_REP_REGION;    1.
PS50088;    ANK_REPEAT;    5.
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PRINTS
PR01415;    ANKYRIN.;   
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Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1    584       POTE ankyrin domain family member D.
                             /FTId=PRO_0000066913.
REPEAT      172    201       ANK 1.
REPEAT      205    234       ANK 2.
REPEAT      238    267       ANK 3.
REPEAT      271    300       ANK 4.
REPEAT      304    333       ANK 5.
REPEAT      337    366       ANK 6.
COILED      494    583       Potential.
VARIANT     113    113       G -> S (in dbSNP:rs6517869).
                             /FTId=VAR_016242.
VARIANT     135    135       I -> V (in dbSNP:rs6517870).
                             /FTId=VAR_016243.
VARIANT     172    172       E -> Q.
                             /FTId=VAR_064765.
CONFLICT    535    535       M -> V (in Ref. 1; AAO23914).
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Nucleotide Sequence
Length: 1826 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 584 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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