TEKTIN1 mRNA was localized to spermatocytes and round spermatids in the seminiferous tubules of the mouse testis, indicating that it may play a role in spermatogenesis.
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1. M. Xu, Z. Zhou, C. Cheng, W. Zhao, R. Tang, Y. Huang, W. Wang, J. Xu, L. Zeng, Y. Xie and Y. Mao (2001) Cloning and characterization of a novel human TEKTIN1 gene. Int J Biochem Cell Biol 33(12): 1172-82.
Abstract Tektins comprise a family of filament-forming proteins that are known to be coassembled with tubulins to form ciliary and flagellar microtubules. A new member of the tektin gene family was cloned from the human fetal brain cDNA library. We hence named it the human TEKTIN1 gene. TEKTIN1 cDNA consists of 1375 bp and has a putative open reading frame encoding 418 amino acids. The predicted protein is 48.3 kDa in size, and its amino acid sequence is 82% identical to that of the mouse, rat, and dog. One conserved peptide RPNVELCRD was observed at position number 323-331 of the amino acid sequence, which is a prominent feature of tektins and is likely to represent a functionally important protein domain. TEKTIN1 gene was mapped to the human chromosome 17 by BLAST search, and at least eight exons were found. Northern blot analysis indicated that TEKTIN1 was predominantly expressed in testis. By in-situ hybridization analysis, TEKTIN1 mRNA was localized to spermatocytes and round spermatids in the seminiferous tubules of the mouse testis, indicating that it may play a role in spermatogenesis. PMID: [11606253]
CHAIN 1 418 Tektin-1. /FTId=PRO_0000184562. COILED 21 107 Potential. COILED 134 177 Potential. COILED 266 308 Potential. COILED 333 384 Potential. VARIANT 146 146 I -> V (in dbSNP:rs34431552). /FTId=VAR_034548. VARIANT 254 254 R -> C (in dbSNP:rs3744395). /FTId=VAR_022150. VARIANT 332 332 V -> I (in dbSNP:rs2271233). /FTId=VAR_022151. Back to Top