SG00000599

SpermatogenesisOnline 1.0

Tag

Content

SG ID

SG00000599

UniProt Accession

CTNB1_HUMAN;P35222;A8K1L7;Q8NEW9;Q8NI94;Q9H391;

Theoretical PI

5.53

Molecular Weight

85497 Da

Genbank Nucleotide ID

X87838; Z19054; AF130085; AY463360; AK289932; AC104307; CH471055; BC058926; AY081165; AB062292;

Genbank Protein ID

CAA61107.1; CAA79497.1; AAG35511.1; AAR18817.1; BAF82621.1; EAW64625.1; AAH58926.1; AAL89457.1; BAB93475.1;

Gene Name

CTNNB1

Gene Synonyms/Alias

CTNNB

Protein Name

Catenin beta-1

Protein Synonyms/Alias

Beta-catenin;

Organism

Homo sapiens (Human)

NCBI Taxonomy ID

9606

Chromosome Location

chr:3;41236328-41301587;1

View in Ensembl genome browser

Function in Stage

postmeiotic

meiotic

premeiotic

Function in Cell Type

spermatocyte

sertoli_cell

spermatid

Description

perinuclear beta-catenin in germ cells may play a specific role in spermatogenesis.

The information of related literatures

1. J. H. Lee, K. W. Choi, S. J. Lee and M. C. Gye (2005) Expression of beta-catenin in human testes with spermatogenic defects. Arch Androl 51(4): 271-6.

Abstract
beta-catenin is a multifunctional molecule that functions in intercellular adhesion and signal transduction during assembly of AJs between Sertoli cells as well as between Sertoli cells and germ cells. To assess changes in the testicular beta-catenin in male infertility conditions, testicular tissues from obstructive azoospermia with normal spermatogenesis, spermatogenic arrest (SA) and Sertoli cell-only syndrome (SCO) patients were examined for immunohistochemical localization of beta-catenin. In normal spermatogenic tissue, expression of beta-catenin was largely found in the Sertoli cell-germ cell (primarily spermatocytes) contact areas. Interestingly, perinuclear localization of beta-catenin was found in spermatocytes and spermatids. In spermatogenic arrest, beta-catenin in cell contact areas between Sertoli cells and germ cells was greatly decreased, but perinuclear beta-catenin in spermatocytes was not. In SCO, weak or negligible immunoreactivity of beta-catenin was found in cell contacts between Sertoli cells. Nuclear localization of beta-catenin was found in myotubular cells in all samples. Taken together, altered expression of beta-catenin in cell contacts within the seminiferous epithelia in spermatogenic arrest and SCO suggests that interactions between Sertoli cells and germ cell are crucial for expression of beta-catenin, and thus functional development of AJs in seminiferous epithelia in human testis. It should be also emphasized that perinuclear beta-catenin in germ cells may play a specific role in spermatogenesis. PMID: [16036634]

Figures for illustrating the function of this protein/gene

Function

Key downstream component of the canonical Wnt signalingpathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2,APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminalSer and Thr residues and ubiquitination of CTNNB1 via BTRC and itssubsequent degradation by the proteasome. In the presence of Wntligand, CTNNB1 is not ubiquitinated and accumulates in thenucleus, where it acts as a coactivator for transcription factorsof the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. Acts as a negativeregulator of centrosome cohesion. Involved in theCDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization.Blocks anoikis of malignant kidney and intestinal epithelial cellsand promotes their anchorage-independent growth by down-regulatingDAPK2.

Subcellular Location

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton.Cell junction, adherens junction. Cell junction. Cell membrane.Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton,spindle pole. Note=Cytoplasmic when it is unstabilized (high levelof phosphorylation) or bound to CDH1. Translocates to the nucleuswhen it is stabilized (low level of phosphorylation). Interactionwith GLIS2 and MUC1 promotes nuclear translocation. Interactionwith EMD inhibits nuclear localization. The majority of beta-catenin is localized to the cell membrane. In interphase,colocalizes with CROCC between CEP250 puncta at the proximal endof centrioles, and this localization is dependent on CROCC andCEP250. In mitosis, when NEK2 activity increases, it localizes tocentrosomes at spindle poles independent of CROCC. Co-localizeswith CDK5 in the cell-cell contacts and plasma membrane ofundifferentiated and differentiated neuroblastoma cells.

Tissue Specificity

Expressed in several hair follicle cell types:basal and peripheral matrix cells, and cells of the outer andinner root sheaths. Expressed in colon. Present in corticalneurons (at protein level).

Gene Ontology

GO ID	GO term	Evidence
GO:0034742	C:APC-Axin-1-beta-catenin complex	IDA:BHF-UCL.
GO:0045177	C:apical part of cell	IEA:Compara.
GO:0034747	C:Axin-APC-beta-catenin-GSK3B complex	IDA:BHF-UCL.
GO:0070369	C:beta-catenin-TCF7L2 complex	IDA:BHF-UCL.
GO:0016342	C:catenin complex	IDA:BHF-UCL.
GO:0005938	C:cell cortex	IDA:BHF-UCL.
GO:0005924	C:cell-substrate adherens junction	IDA:BHF-UCL.
GO:0005813	C:centrosome	IDA:UniProtKB.
GO:0043198	C:dendritic shaft	IBA:RefGenome.
GO:0030057	C:desmosome	IBA:RefGenome.
GO:0005916	C:fascia adherens	IBA:RefGenome.
GO:0009898	C:internal side of plasma membrane	IBA:RefGenome.
GO:0030027	C:lamellipodium	IBA:RefGenome.
GO:0016328	C:lateral plasma membrane	IDA:MGI.
GO:0005624	C:membrane fraction	IEA:Compara.
GO:0031528	C:microvillus membrane	IBA:RefGenome.
GO:0048471	C:perinuclear region of cytoplasm	IDA:UniProtKB.
GO:0032993	C:protein-DNA complex	IDA:BHF-UCL.
GO:0034750	C:Scrib-APC-beta-catenin complex	IEA:Compara.
GO:0000922	C:spindle pole	IEA:UniProtKB-SubCell.
GO:0045202	C:synapse	IBA:RefGenome.
GO:0005667	C:transcription factor complex	IDA:BHF-UCL.
GO:0030018	C:Z disc	IBA:RefGenome.
GO:0005915	C:zonula adherens	IBA:RefGenome.
GO:0003682	F:chromatin binding	IEA:Compara.
GO:0003690	F:double-stranded DNA binding	IEA:Compara.
GO:0003700	F:sequence-specific DNA binding transcription factor activity	IEA:Compara.
GO:0004871	F:signal transducer activity	NAS:ProtInc.
GO:0005198	F:structural molecule activity	IBA:RefGenome.
GO:0003713	F:transcription coactivator activity	IMP:UniProtKB.
GO:0044212	F:transcription regulatory region DNA binding	IDA:UniProtKB.
GO:0034333	P:adherens junction assembly	IMP:BHF-UCL.
GO:0030521	P:androgen receptor signaling pathway	NAS:UniProtKB.
GO:0009948	P:anterior/posterior axis specification	IEA:Compara.
GO:0045453	P:bone resorption	IEA:Compara.
GO:0001658	P:branching involved in ureteric bud morphogenesis	IBA:RefGenome.
GO:0044336	P:canonical Wnt receptor signaling pathway involved in negative regulation of apoptotic process	IMP:BHF-UCL.
GO:0061324	P:canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation	ISS:BHF-UCL.
GO:0044334	P:canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition	IMP:BHF-UCL.
GO:0001708	P:cell fate specification	IEA:Compara.
GO:0048469	P:cell maturation	IEA:Compara.
GO:0016337	P:cell-cell adhesion	IMP:BHF-UCL.
GO:0007160	P:cell-matrix adhesion	IBA:RefGenome.
GO:0006921	P:cellular component disassembly involved in apoptotic process	TAS:Reactome.
GO:0071363	P:cellular response to growth factor stimulus	IMP:BHF-UCL.
GO:0071681	P:cellular response to indole-3-methanol	IDA:UniProtKB.
GO:0071407	P:cellular response to organic cyclic compound	IEA:Compara.
GO:0022009	P:central nervous system vasculogenesis	IBA:RefGenome.
GO:0007016	P:cytoskeletal anchoring at plasma membrane	IBA:RefGenome.
GO:0048262	P:determination of dorsal/ventral asymmetry	IBA:RefGenome.
GO:0009950	P:dorsal/ventral axis specification	IBA:RefGenome.
GO:0007398	P:ectoderm development	IBA:RefGenome.
GO:0035117	P:embryonic arm morphogenesis	IEA:Compara.
GO:0000578	P:embryonic axis specification	IBA:RefGenome.
GO:0042733	P:embryonic digit morphogenesis	IEA:Compara.
GO:0048617	P:embryonic foregut morphogenesis	IBA:RefGenome.
GO:0035050	P:embryonic heart tube development	IEA:Compara.
GO:0035116	P:embryonic hindlimb morphogenesis	IEA:Compara.
GO:0036023	P:embryonic skeletal limb joint morphogenesis	ISS:BHF-UCL.
GO:0001711	P:endodermal cell fate commitment	IBA:RefGenome.
GO:0061154	P:endothelial tube morphogenesis	IMP:BHF-UCL.
GO:0060742	P:epithelial cell differentiation involved in prostate gland development	IEA:Compara.
GO:0001837	P:epithelial to mesenchymal transition	TAS:HGNC.
GO:0060441	P:epithelial tube branching involved in lung morphogenesis	IEA:Compara.
GO:0030900	P:forebrain development	IEA:Compara.
GO:0061198	P:fungiform papilla formation	IEA:Compara.
GO:0001702	P:gastrulation with mouth forming second	IBA:RefGenome.
GO:0035112	P:genitalia morphogenesis	IEA:Compara.
GO:0007403	P:glial cell fate determination	IBA:RefGenome.
GO:0035315	P:hair cell differentiation	TAS:BHF-UCL.
GO:0031069	P:hair follicle morphogenesis	IBA:RefGenome.
GO:0060789	P:hair follicle placode formation	IBA:RefGenome.
GO:0030902	P:hindbrain development	IBA:RefGenome.
GO:0001701	P:in utero embryonic development	IEA:Compara.
GO:0002089	P:lens morphogenesis in camera-type eye	IEA:Compara.
GO:0001889	P:liver development	IBA:RefGenome.
GO:0060479	P:lung cell differentiation	IBA:RefGenome.
GO:0060492	P:lung induction	IBA:RefGenome.
GO:0060484	P:lung-associated mesenchyme development	IBA:RefGenome.
GO:0030539	P:male genitalia development	IBA:RefGenome.
GO:0060916	P:mesenchymal cell proliferation involved in lung development	IBA:RefGenome.
GO:0003337	P:mesenchymal to epithelial transition involved in metanephros morphogenesis	IBA:RefGenome.
GO:0007494	P:midgut development	IEA:Compara.
GO:0045445	P:myoblast differentiation	IEA:Compara.
GO:0008285	P:negative regulation of cell proliferation	IDA:UniProtKB.
GO:0032331	P:negative regulation of chondrocyte differentiation	IBA:RefGenome.
GO:0003136	P:negative regulation of heart induction by canonical Wnt receptor signaling pathway	IBA:RefGenome.
GO:0048715	P:negative regulation of oligodendrocyte differentiation	IEA:Compara.
GO:0045671	P:negative regulation of osteoclast differentiation	IBA:RefGenome.
GO:0000122	P:negative regulation of transcription from RNA polymerase II promoter	IBA:RefGenome.
GO:0072079	P:nephron tubule formation	IBA:RefGenome.
GO:0001764	P:neuron migration	IEA:Compara.
GO:0042475	P:odontogenesis of dentin-containing tooth	IBA:RefGenome.
GO:0048599	P:oocyte development	IBA:RefGenome.
GO:0030316	P:osteoclast differentiation	IEA:Compara.
GO:0060066	P:oviduct development	IEA:Compara.
GO:0031016	P:pancreas development	IBA:RefGenome.
GO:0001569	P:patterning of blood vessels	IC:BHF-UCL.
GO:0045768	P:positive regulation of anti-apoptosis	IMP:BHF-UCL.
GO:0043065	P:positive regulation of apoptotic process	IDA:UniProtKB.
GO:0061047	P:positive regulation of branching involved in lung morphogenesis	IBA:RefGenome.
GO:2000017	P:positive regulation of determination of dorsal identity	IEA:Compara.
GO:0045603	P:positive regulation of endothelial cell differentiation	IEA:Compara.
GO:0060769	P:positive regulation of epithelial cell proliferation involved in prostate gland development	IBA:RefGenome.
GO:0045743	P:positive regulation of fibroblast growth factor receptor signaling pathway	IBA:RefGenome.
GO:0010909	P:positive regulation of heparan sulfate proteoglycan biosynthetic process	IMP:BHF-UCL.
GO:0043123	P:positive regulation of I-kappaB kinase/NF-kappaB cascade	IBA:RefGenome.
GO:0043410	P:positive regulation of MAPK cascade	IBA:RefGenome.
GO:0002053	P:positive regulation of mesenchymal cell proliferation	IEA:Compara.
GO:0051149	P:positive regulation of muscle cell differentiation	TAS:Reactome.
GO:0002052	P:positive regulation of neuroblast proliferation	IEA:Compara.
GO:0045669	P:positive regulation of osteoblast differentiation	IBA:RefGenome.
GO:0045944	P:positive regulation of transcription from RNA polymerase II promoter	IDA:BHF-UCL.
GO:0034394	P:protein localization at cell surface	IMP:BHF-UCL.
GO:0009954	P:proximal/distal pattern formation	IBA:RefGenome.
GO:0045765	P:regulation of angiogenesis	TAS:BHF-UCL.
GO:0090279	P:regulation of calcium ion import	IDA:BHF-UCL.
GO:0030997	P:regulation of centriole-centriole cohesion	IDA:UniProtKB.
GO:0070602	P:regulation of centromeric sister chromatid cohesion	IMP:BHF-UCL.
GO:0048145	P:regulation of fibroblast proliferation	TAS:BHF-UCL.
GO:0031641	P:regulation of myelination	IEA:Compara.
GO:0072182	P:regulation of nephron tubule epithelial cell differentiation	ISS:UniProtKB.
GO:2000008	P:regulation of protein localization at cell surface	IDA:BHF-UCL.
GO:0003266	P:regulation of secondary heart field cardioblast proliferation	IEA:Compara.
GO:0048660	P:regulation of smooth muscle cell proliferation	IMP:BHF-UCL.
GO:0042129	P:regulation of T cell proliferation	IBA:RefGenome.
GO:0072053	P:renal inner medulla development	IBA:RefGenome.
GO:0072054	P:renal outer medulla development	IBA:RefGenome.
GO:0072033	P:renal vesicle formation	IBA:RefGenome.
GO:0046686	P:response to cadmium ion	IEA:Compara.
GO:0034097	P:response to cytokine stimulus	IEA:Compara.
GO:0042493	P:response to drug	IEP:UniProtKB.
GO:0032355	P:response to estradiol stimulus	IDA:BHF-UCL.
GO:0014010	P:Schwann cell proliferation	IBA:RefGenome.
GO:0043588	P:skin development	IEA:Compara.
GO:0051145	P:smooth muscle cell differentiation	IBA:RefGenome.
GO:0050808	P:synapse organization	IBA:RefGenome.
GO:0048489	P:synaptic vesicle transport	IBA:RefGenome.
GO:0033077	P:T cell differentiation in thymus	IBA:RefGenome.
GO:0048538	P:thymus development	IBA:RefGenome.
GO:0043587	P:tongue morphogenesis	IBA:RefGenome.
GO:0060440	P:trachea formation	IBA:RefGenome.
GO:0006351	P:transcription, DNA-dependent	IEA:UniProtKB-KW.

Interpro

IPR011989;    ARM-like.
IPR016024;    ARM-type_fold.
IPR000225;    Armadillo.
IPR013284;    Beta-catenin.
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Pfam

PF00514; Arm; 4.
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SMART

SM00185; ARM; 12.
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PROSITE

PS50176; ARM_REPEAT; 9.
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PRINTS

PR01869; BCATNINFAMLY.;
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Created Date

18-Oct-2012

Record Type

Experiment identified

Protein sequence Annotation

CHAIN         1    781       Catenin beta-1.
                             /FTId=PRO_0000064271.
REPEAT      151    191       ARM 1.
REPEAT      193    234       ARM 2.
REPEAT      235    276       ARM 3.
REPEAT      277    318       ARM 4.
REPEAT      319    360       ARM 5.
REPEAT      361    389       ARM 6.
REPEAT      400    441       ARM 7.
REPEAT      442    484       ARM 8.
REPEAT      489    530       ARM 9.
REPEAT      531    571       ARM 10.
REPEAT      594    636       ARM 11.
REPEAT      637    666       ARM 12.
REGION        1     23       Interaction with VCL (By similarity).
REGION      772    781       Interaction with SCRIB (By similarity).
MOD_RES      23     23       Phosphoserine; by GSK3-beta.
MOD_RES      29     29       Phosphoserine; by GSK3-beta.
MOD_RES      33     33       Phosphoserine; by GSK3-beta and HIPK2.
MOD_RES      37     37       Phosphoserine; by GSK3-beta and HIPK2.
MOD_RES      41     41       Phosphothreonine; by GSK3-beta.
MOD_RES      45     45       Phosphoserine.
MOD_RES      64     64       Phosphotyrosine; by PTK6.
MOD_RES      86     86       Phosphotyrosine; by CSK.
MOD_RES     142    142       Phosphotyrosine; by FYN and PTK6.
MOD_RES     191    191       Phosphoserine; by CDK5.
MOD_RES     246    246       Phosphoserine; by CDK5.
MOD_RES     331    331       Phosphotyrosine; by PTK6.
MOD_RES     333    333       Phosphotyrosine; by PTK6 (Probable).
MOD_RES     551    551       Phosphothreonine.
MOD_RES     552    552       Phosphoserine; by AMPK (Probable).
MOD_RES     556    556       Phosphothreonine.
MOD_RES     654    654       Phosphotyrosine; by CSK.
MOD_RES     675    675       Phosphoserine.
VAR_SEQ       1    565       Missing (in isoform 2).
                             /FTId=VSP_006984.
VAR_SEQ     652    653       AT -> GK (in isoform 2).
                             /FTId=VSP_006985.
VAR_SEQ     654    781       Missing (in isoform 2).
                             /FTId=VSP_006986.
VARIANT      23     23       S -> R (in hepatocellular carcinoma; no
                             effect).
                             /FTId=VAR_017612.
VARIANT      25     33       Missing (in hepatocellular carcinoma).
                             /FTId=VAR_017613.
VARIANT      32     32       D -> A (in hepatocellular carcinoma).
                             /FTId=VAR_017614.
VARIANT      32     32       D -> G (in PTR and hepatocellular
                             carcinoma).
                             /FTId=VAR_017615.
VARIANT      32     32       D -> Y (in PTR, hepatoblastoma and
                             hepatocellular carcinoma;
                             dbSNP:rs28931588).
                             /FTId=VAR_017616.
VARIANT      33     33       S -> F (in PTR, MDB and hepatocellular
                             carcinoma).
                             /FTId=VAR_017617.
VARIANT      33     33       S -> L (in hepatocellular carcinoma).
                             /FTId=VAR_017618.
VARIANT      33     33       S -> Y (in colorectal cancer and PTR;
                             enhances transactivation of target
                             genes).
                             /FTId=VAR_017619.
VARIANT      34     34       G -> E (in PTR).
                             /FTId=VAR_017620.
VARIANT      34     34       G -> R (in hepatocellular carcinoma).
                             /FTId=VAR_017621.
VARIANT      34     34       G -> V (in hepatoblastoma;
                             dbSNP:rs28931589).
                             /FTId=VAR_017622.
VARIANT      35     35       I -> S (in hepatocellular carcinoma).
                             /FTId=VAR_017623.
VARIANT      37     38       SG -> W (in hepatocellular carcinoma).
                             /FTId=VAR_017628.
VARIANT      37     37       S -> A (in MDB and hepatocellular
                             carcinoma; enhances transactivation of
                             target genes).
                             /FTId=VAR_017624.
VARIANT      37     37       S -> C (in PTR, hepatoblastoma and
                             ovarian cancer).
                             /FTId=VAR_017625.
VARIANT      37     37       S -> F (in PTR).
                             /FTId=VAR_017626.
VARIANT      37     37       S -> Y (in hepatocellular carcinoma).
                             /FTId=VAR_017627.
VARIANT      41     41       T -> A (in hepatoblastoma and
                             hepatocellular carcinoma; also in a
                             desmoid tumor; strongly reduces
                             phosphorylation and degradation;
                             abolishes phosphorylation on Ser-33 and
                             Ser-37 and enhances transactivation of
                             target genes).
                             /FTId=VAR_017629.
VARIANT      41     41       T -> I (in PTR, hepatocellular carcinoma
                             and ovarian cancer).
                             /FTId=VAR_017630.
VARIANT      45     45       S -> F (in hepatocellular carcinoma).
                             /FTId=VAR_017631.
VARIANT      45     45       S -> P (in hepatocellular carcinoma).
                             /FTId=VAR_017632.
VARIANT      45     45       Missing (in colorectal cancer).
                             /FTId=VAR_055430.
VARIANT     688    688       M -> V (in dbSNP:rs4135384).
                             /FTId=VAR_018954.
MUTAGEN      29     29       S->F: No effect.
MUTAGEN      64     64       Y->F: Abolishes phosphorylation by PTK6.
MUTAGEN     253    253       F->A: Abolishes or strongly reduces AXIN2
                             binding.
MUTAGEN     260    260       H->A: Abolishes or strongly reduces AXIN1
                             and AXIN2 binding. Strongly reduces
                             phosphorylation and degradation; when
                             associated with A-386 and A-383.
MUTAGEN     292    292       K->A: Abolishes or strongly reduces AXIN1
                             and AXIN2 binding.
MUTAGEN     312    312       K->E: Abolishes TCF7L2 binding.
MUTAGEN     345    345       K->A: Abolishes APC binding.
MUTAGEN     383    383       W->A: Abolishes APC binding. Strongly
                             reduces phosphorylation and degradation;
                             when associated with A-260 and A-386.
MUTAGEN     386    386       R->A: Strongly reduces APC binding.
                             Strongly reduces phosphorylation and
                             degradation; when associated with A-260
                             and A-383.
MUTAGEN     426    426       N->A: Abolishes TCF7L2 and LEF1 binding.
MUTAGEN     435    435       K->A: Strongly reduces or abolishes LEF1
                             binding.
MUTAGEN     435    435       K->E: Abolishes TCF7L2 binding.
MUTAGEN     469    469       R->A: Abolishes TCF7L2 binding, and
                             strongly reduces or abolishes LEF1
                             binding.
MUTAGEN     470    470       H->A: Abolishes TCF7L2 binding, and
                             strongly reduces or abolishes LEF1
                             binding.
MUTAGEN     508    508       K->A: Abolishes TCF7L2 and LEF1 binding.
MUTAGEN     654    654       Y->E: Enhances TBP binding and
                             transactivation of target genes.
MUTAGEN     654    654       Y->F: Abolishes increase of TBP binding
                             after phosphorylation by CSK.
MUTAGEN     660    660       F->A: Abolishes CTNNBIP1 binding; when
                             associated with A-661.
MUTAGEN     661    661       R->A: Abolishes CTNNBIP1 binding; when
                             associated with A-660.
TURN         20     22
STRAND       23     26
TURN         27     29
TURN         39     41
HELIX       135    150
HELIX       152    160
HELIX       165    179
HELIX       182    189
HELIX       192    204
HELIX       208    221
HELIX       225    233
HELIX       236    243
HELIX       249    265
HELIX       269    276
HELIX       278    284
HELIX       285    287
HELIX       291    305
HELIX       309    317
HELIX       320    330
HELIX       334    347
HELIX       353    359
HELIX       362    367
TURN        368    371
HELIX       375    389
HELIX       399    408
HELIX       414    427
TURN        428    430
HELIX       432    440
HELIX       443    454
HELIX       458    471
STRAND      473    475
HELIX       478    487
HELIX       491    496
HELIX       504    517
HELIX       521    523
HELIX       524    529
HELIX       532    547
STRAND      550    552
STRAND      554    557
STRAND      561    563
HELIX       566    580
HELIX       584    592
HELIX       596    601
HELIX       602    604
HELIX       608    621
HELIX       625    633
HELIX       637    642
HELIX       643    645
HELIX       649    662
TURN        663    665
HELIX       668    682
HELIX       688    690
STRAND      778    780
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Nucleotide Sequence

Length: 3362 bp Go to nucleotide: FASTA

Protein Sequence

Length: 781 bp Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt	Gene Symbol	Ref Databases
A1L467_HUMAN	MET	BioGRID
A5YRU5_HUMAN	MUC1	BioGRID
A5YRU7_HUMAN	MUC1	BioGRID
A5YRV0_HUMAN	MUC1	BioGRID
A5YRV2_HUMAN	MUC1	BioGRID
A6ZID6_HUMAN	MUC1	BioGRID
A6ZID7_HUMAN	MUC1	BioGRID
A6ZID9_HUMAN	MUC1	BioGRID
A6ZIE0_HUMAN	MUC1	BioGRID
A6ZIE4_HUMAN	MUC1	BioGRID
A6ZIE6_HUMAN	MUC1	BioGRID
A7E2E1_HUMAN	SMARCA4	BioGRID
A7MBN1_HUMAN	PTPRM	HPRD
A8K0H7_HUMAN	_	HPRD
A8K141_HUMAN	CTNNA3	HPRD
A8K1U7_HUMAN	CDH1	BioGRID
A8K3M3_HUMAN	PTPN1	HPRD
A8K4I2_HUMAN	HIST1H1C	BioGRID
A8K6H6_HUMAN	_	HPRD
A8K9B1_HUMAN	SPN	HPRD
ABL1_HUMAN	ABL1	MINT
ACSA_YERPE	acs	IntAct
AJAP1_HUMAN	AJAP1	HPRD
AKA12_HUMAN	AKAP12	IntAct
ANDR_HUMAN	AR	HPRD
ANDR_RAT	Ar	BioGRID
AP2A_HUMAN	TFAP2A	HPRD
AP3D1_HUMAN	AP3D1	IntAct
APC2_HUMAN	APC2	HPRD
APC_HUMAN	APC	HPRD
AXIN1_HUMAN	AXIN1	HPRD
AXIN1_MOUSE	Axin1	BioGRID
AXIN1_RAT	Axin1	BioGRID
AXIN1_XENLA	axin1	IntAct
AXIN2_HUMAN	AXIN2	HPRD
B0LPF1	FLT1	HPRD
B0UXA9_HUMAN	CSNK2B	HPRD
B1A8Z4_HUMAN	_	BioGRID
B1A8Z5_HUMAN	_	BioGRID
B1A8Z6_HUMAN	_	BioGRID
B1A8Z7_HUMAN	SMARCA4	BioGRID
B1AVQ5_HUMAN	MUC1	BioGRID
B1AVR0_HUMAN	MUC1	BioGRID
B2RTQ8	PTPRK	HPRD
B3KNW7_HUMAN	_	BioGRID
B3KS52_HUMAN	PICK1	HPRD
B3KVA4_HUMAN	_	HPRD
B3KYA8_HUMAN	_	BioGRID
B4DDT5_HUMAN	_	BioGRID
B4DHC3_HUMAN	_	BioGRID
B4DRJ8_HUMAN	TCF7L2	BioGRID
B4E1G3_HUMAN	_	BioGRID
B6ECB3_HUMAN	MUC1	BioGRID
B7Z2B6_HUMAN	_	BioGRID
B7Z4Z5_HUMAN	_	BioGRID
B7Z773_HUMAN	_	BioGRID
B7Z8E2_HUMAN	_	BioGRID
B7Z8T7_HUMAN	_	BioGRID
B7Z9Q2_HUMAN	_	BioGRID
B9A012_HUMAN	MYO7A	BioGRID
B9X074_HUMAN	TCF7L2	BioGRID
BCCIP_HUMAN	BCCIP	IntAct
BCL3_HUMAN	BCL3	HPRD
BCL9_DROME	lgs	IntAct
BCL9_HUMAN	BCL9	HPRD
BOC_HUMAN	BOC	HPRD
C6ZRJ7_HUMAN	_	BioGRID
C6ZRJ8_HUMAN	TCF7L2	BioGRID
C6ZRJ9_HUMAN	_	BioGRID
C6ZRK0_HUMAN	_	BioGRID
C6ZRK1_HUMAN	_	BioGRID
C6ZRK2_HUMAN	_	BioGRID
C6ZRK5_HUMAN	TCF7L2	BioGRID
C9JA96_HUMAN	DAZAP2	BioGRID
C9JP84_HUMAN	DAZAP2	BioGRID
CAD11_HUMAN	CDH11	HPRD
CAD16_HUMAN	CDH16	HPRD
CAD24_HUMAN	CDH24	HPRD
CADH1_HUMAN	CDH1	BioGRID
CADH2_HUMAN	CDH2	BioGRID
CADH3_HUMAN	CDH3	BioGRID
CADH5_HUMAN	CDH5	HPRD
CADH7_HUMAN	CDH7	HPRD
CADH8_HUMAN	CDH8	HPRD
CADH9_HUMAN	CDH9	HPRD
CAH9_HUMAN	CA9	HPRD
CASP3_HUMAN	CASP3	HPRD
CASP8_HUMAN	CASP8	HPRD
CAV1_CANFA	CAV1	IntAct
CBP_HUMAN	CREBBP	HPRD
CBY1_HUMAN	CBY1	HPRD
CCND1_HUMAN	CCND1	HPRD
CD5R1_HUMAN	CDK5R1	HPRD
CDC27_HUMAN	CDC27	BioGRID
CDC73_HUMAN	CDC73	HPRD
CDON_HUMAN	CDON	HPRD
CEBPA_HUMAN	CEBPA	HPRD
CIP4_HUMAN	TRIP10	HPRD
CNBP1_HUMAN	CTNNBIP1	HPRD
CSK21_HUMAN	CSNK2A1	HPRD
CSK2B_HUMAN	CSNK2B	HPRD
CTNA1_HUMAN	CTNNA1	BioGRID
CTNA3_HUMAN	CTNNA3	HPRD
1433Z_HUMAN	YWHAZ	MINT
A1L467_HUMAN	MET	HPRD
A1Z199_HUMAN	BCR/ABL	MINT
A3QNQ0_HUMAN	TGFBR2	BioGRID
A4D0U1_HUMAN	IFRD1	BioGRID
A4D1G0_HUMAN	CDK6	HPRD
A5YRU5_HUMAN	MUC1	BioGRID
A5YRU7_HUMAN	MUC1	BioGRID
A5YRV0_HUMAN	MUC1	BioGRID
A5YRV2_HUMAN	MUC1	BioGRID
A6ZID6_HUMAN	MUC1	BioGRID
A6ZID7_HUMAN	MUC1	BioGRID
A6ZID9_HUMAN	MUC1	BioGRID
A6ZIE0_HUMAN	MUC1	BioGRID
A6ZIE4_HUMAN	MUC1	BioGRID
A6ZIE6_HUMAN	MUC1	BioGRID
A7E2E1_HUMAN	SMARCA4	BioGRID
A8K1U7_HUMAN	CDH1	BioGRID
A8K6H6_HUMAN	_	BioGRID
A8MSJ8	MYC	IntAct
ACTN4_HUMAN	ACTN4	IntAct
AHR_HUMAN	AHR	DIP
AN32A_HUMAN	ANP32A	IntAct
ANDR_HUMAN	AR	BioGRID
APC2_HUMAN	APC2	BioGRID
APC_HUMAN	APC	BioGRID
ARI4B_HUMAN	ARID4B	IntAct
ASH2L_HUMAN	ASH2L	BioGRID
AXIN1_HUMAN	AXIN1	BioGRID
AXIN1_MOUSE	Axin1	MINT
B1A8Z4_HUMAN	_	BioGRID
B1A8Z5_HUMAN	_	BioGRID
B1A8Z6_HUMAN	_	BioGRID
B1A8Z7_HUMAN	SMARCA4	BioGRID
B1AVQ5_HUMAN	MUC1	BioGRID
B1AVR0_HUMAN	MUC1	BioGRID
B2R778_HUMAN	_	BioGRID
B2R8E4_HUMAN	_	HPRD
B3KNW7_HUMAN	_	BioGRID
B3KSF1_HUMAN	_	BioGRID
B3KVA4_HUMAN	_	BioGRID
B3KXA2_HUMAN	_	BioGRID
B4DHG6_HUMAN	_	BioGRID
B4DLF8_HUMAN	_	BioGRID
B4DP95_HUMAN	_	BioGRID
B4DRJ8_HUMAN	TCF7L2	BioGRID
B4DZ30	_	BioGRID
B5MCC7_HUMAN	ACP1	BioGRID
B6ECB3_HUMAN	MUC1	BioGRID
B7Z2B6_HUMAN	_	BioGRID
B7Z5G1_HUMAN	_	BioGRID
B7Z8E2_HUMAN	_	BioGRID
B7Z8T7_HUMAN	_	BioGRID
B9X074_HUMAN	TCF7L2	BioGRID
BCL9L_HUMAN	BCL9L	HPRD
BCL9L_MOUSE	Bcl9l	BioGRID
BCL9_HUMAN	BCL9	IntAct
BRX1_HUMAN	BRIX1	IntAct
C6ZRJ7_HUMAN	_	BioGRID
C6ZRJ8_HUMAN	TCF7L2	BioGRID
C6ZRJ9_HUMAN	_	BioGRID
C6ZRK0_HUMAN	_	BioGRID
C6ZRK1_HUMAN	_	BioGRID
C6ZRK2_HUMAN	_	BioGRID
C6ZRK5_HUMAN	TCF7L2	BioGRID
CAD10_HUMAN	CDH10	BioGRID
CAD11_HUMAN	CDH11	BioGRID
CAD15_HUMAN	CDH15	HPRD
CAD17_HUMAN	CDH17	BioGRID
CAD18_HUMAN	CDH18	BioGRID
CADH1_HUMAN	CDH1	BioGRID
CADH1_MOUSE	Cdh1	IntAct
CADH2_HUMAN	CDH2	HPRD
CADH3_HUMAN	CDH3	HPRD
CADH5_HUMAN	CDH5	BioGRID
CADH6_HUMAN	CDH6	BioGRID
CADH7_HUMAN	CDH7	BioGRID
CADH9_HUMAN	CDH9	BioGRID
CARM1_HUMAN	CARM1	BioGRID
CBP_HUMAN	CREBBP	BioGRID
CBY1_HUMAN	CBY1	BioGRID
CCND1_HUMAN	CCND1	IntAct
CD5R1_HUMAN	CDK5R1	BioGRID
CDC73_HUMAN	CDC73	IntAct
CDK6_HUMAN	CDK6	HPRD
CEBPA_HUMAN	CEBPA	BioGRID
CHD8_HUMAN	CHD8	HPRD
CLCA_HUMAN	CLTA	IntAct
CNBP1_HUMAN	CTNNBIP1	IntAct
CNBP1_MOUSE	Ctnnbip1	MINT
CTNA1_HUMAN	CTNNA1	HPRD
CTND1_HUMAN	CTNND1	BioGRID
CUL1_HUMAN	CUL1	IntAct
CX026_HUMAN	CXorf26	IntAct
CYBP_HUMAN	CACYBP	BioGRID
D0VY79_HUMAN	HIF1A	HPRD
D2JYI1_HUMAN	TGFBR2	HPRD
DDB1_HUMAN	DDB1	DIP
DISC1_MOUSE	Disc1	IntAct
DP13A_HUMAN	APPL1	IntAct
E5RGD7_HUMAN	MYC	IntAct
E7ESE5	MUC1	BioGRID
E7EUG9	MUC1	BioGRID
E9PDK3_HUMAN	LEF1	BioGRID
E9PH46	IKBKB	BioGRID
E9PHA1_HUMAN	PCSK1	BioGRID
E9PQG7_HUMAN	MLL	BioGRID
ELYS_HUMAN	AHCTF1	IntAct
EMD_HUMAN	EMD	MINT
EP300_HUMAN	EP300	HPRD
EP400_HUMAN	EP400	BioGRID
ERBB2_HUMAN	ERBB2	BioGRID
ESR1_HUMAN	ESR1	BioGRID
EZH2_HUMAN	EZH2	BioGRID
EZRI_HUMAN	EZR	BioGRID
F1D8N5_HUMAN	NR3C4	BioGRID
F1D8Q5_HUMAN	NR2B1	HPRD
F1D8S2_HUMAN	NR2A1	BioGRID
F1D8T0_HUMAN	NR2A1	BioGRID
F1D8T1_HUMAN	NR2A1	BioGRID
FBW1A_HUMAN	BTRC	BioGRID
FGFR1_HUMAN	FGFR1	IntAct
FHIT_HUMAN	FHIT	DIP
FHL2_HUMAN	FHL2	BioGRID
FOXO1_HUMAN	FOXO1	HPRD
FOXO3_HUMAN	FOXO3	BioGRID
FOXO4_HUMAN	FOXO4	HPRD
GLIS2_HUMAN	GLIS2	MINT
GSK3B_HUMAN	GSK3B	BioGRID
HDAC1_HUMAN	HDAC1	BioGRID
HDAC4_HUMAN	HDAC4	BioGRID
HDAC7_HUMAN	HDAC7	BioGRID
HIC1_HUMAN	HIC1	MINT
HIF1A_HUMAN	HIF1A	HPRD
HNF4A_HUMAN	HNF4A	BioGRID
IFRD1_HUMAN	IFRD1	BioGRID
IKKA_HUMAN	CHUK	BioGRID
IKKB_HUMAN	IKBKB	BioGRID
ITF2_HUMAN	TCF4	BioGRID
JADE1_HUMAN	PHF17	BioGRID
KAT2A_HUMAN	KAT2A	BioGRID
KAT2B_HUMAN	KAT2B	BioGRID
LAP2B_HUMAN	TMPO	MINT
LEF1_HUMAN	LEF1	BioGRID
LEF1_MOUSE	Lef1	DIP
LEO1_HUMAN	LEO1	HPRD
LMBL3_HUMAN	L3MBTL3	IntAct
LRP2_HUMAN	LRP2	IntAct
LRP6_MOUSE	Lrp6	DIP
MAGI1_HUMAN	MAGI1	HPRD
MEN1_HUMAN	MEN1	BioGRID
MET_HUMAN	MET	HPRD
MLL1_HUMAN	MLL	BioGRID
MLL2_HUMAN	MLL2	BioGRID
MTAD_BACAN	mtaD	IntAct
MUC1_HUMAN	MUC1	BioGRID
MYC_HUMAN	MYC	IntAct
NCOA2_HUMAN	NCOA2	MINT
NDRG1_HUMAN	NDRG1	IntAct
NEC1_HUMAN	PCSK1	BioGRID
NFKB1_HUMAN	NFKB1	HPRD
NHRF1_HUMAN	SLC9A3R1	BioGRID
P85A_HUMAN	PIK3R1	BioGRID
PDIP3_HUMAN	POLDIP3	String
PHB2_HUMAN	PHB2	IntAct
PIN1_HUMAN	PIN1	BioGRID
PITX2_HUMAN	PITX2	BioGRID
PLAK_HUMAN	JUP	BioGRID
PLK1_HUMAN	PLK1	HPRD
PPAC_HUMAN	ACP1	BioGRID
PPM1A_HUMAN	PPM1A	HPRD
PR38B_HUMAN	PRPF38B	IntAct
PSN1_HUMAN	PSEN1	HPRD
PSN2_HUMAN	PSEN2	HPRD
PTN14_HUMAN	PTPN14	BioGRID
PTPRU_HUMAN	PTPRU	BioGRID
Q0VAP5_HUMAN	MUC1	BioGRID
Q0VAP6_HUMAN	MUC1	BioGRID
Q2XQU9_HUMAN	_	BioGRID
Q32ND9_HUMAN	IKBKB	BioGRID
Q4LE28_HUMAN	CREBBP	BioGRID
Q4LE70_HUMAN	APC	BioGRID
Q59EH3_HUMAN	_	BioGRID
Q59FG6_HUMAN	_	BioGRID
Q5R370_HUMAN	CACYBP	BioGRID
Q5R371_HUMAN	CACYBP	BioGRID
Q5W141_HUMAN	BTRC	BioGRID
Q659G9_HUMAN	DKFZp586H0919	BioGRID
Q6FHW4_HUMAN	TCF7L2	BioGRID
Q6FI00_HUMAN	CCND1	IntAct
Q6FI27_HUMAN	GSK3B	BioGRID
Q6I9R8_HUMAN	FHL2	BioGRID
Q6IT96_HUMAN	HDAC1	BioGRID
Q6P3U7_HUMAN	RXRA	HPRD
Q6P468_HUMAN	USP9X	BioGRID
Q6PIA1_HUMAN	MLL2	BioGRID
Q7Z538_HUMAN	MUC1	BioGRID
Q7Z550_HUMAN	MUC1	BioGRID
Q7Z551_HUMAN	MUC1	BioGRID
Q7Z6C1_HUMAN	EP300	HPRD
Q81U78_BACAN	BAS0940	IntAct
Q81XV4_BACAN	BAS3531	IntAct
Q86X58_HUMAN	USP9X	BioGRID
Q86YH7_HUMAN	HDAC4	BioGRID
Q8N619_HUMAN	CDK5R1	BioGRID
Q9GZQ5_HUMAN	MEN1	BioGRID
Q9HBD4_HUMAN	SMARCA4	BioGRID
Q9NUA2_HUMAN	_	BioGRID
Q9UBT1_HUMAN	_	BioGRID
RBBP5_HUMAN	RBBP5	BioGRID
RBM39_HUMAN	RBM39	IntAct
RBX1_HUMAN	RBX1	IntAct
RL41_HUMAN	RPL41	IntAct
RPOB_BACAN	rpoB	IntAct
RUNX3_HUMAN	RUNX3	IntAct
RUVB1_HUMAN	RUVBL1	BioGRID
RUVB2_HUMAN	RUVBL2	HPRD
RXRA_HUMAN	RXRA	HPRD
SALL1_HUMAN	SALL1	HPRD
SKP1_HUMAN	SKP1	BioGRID
SMAD7_HUMAN	SMAD7	HPRD
SMCA4_HUMAN	SMARCA4	BioGRID
SMCA5_HUMAN	SMARCA5	BioGRID
SOX1_HUMAN	SOX1	HPRD
SOX6_HUMAN	SOX6	BioGRID
STK39_HUMAN	STK39	IntAct
SYR1_BACAN	argS1	IntAct
TCF7_HUMAN	TCF7	MINT
TF7L1_HUMAN	TCF7L1	BioGRID
TF7L2_HUMAN	TCF7L2	BioGRID
TGFR2_HUMAN	TGFBR2	HPRD
TNIK_HUMAN	TNIK	MINT
TOP2A_HUMAN	TOP2A	IntAct
TRRAP_HUMAN	TRRAP	BioGRID
TX1B3_HUMAN	TAX1BP3	HPRD
UB2D2_HUMAN	UBE2D2	IntAct
UBA1_HUMAN	UBA1	IntAct
UBC_HUMAN	UBC	BioGRID
USP9X_HUMAN	USP9X	BioGRID
VINC_HUMAN	VCL	BioGRID
ZFYV9_HUMAN	ZFYVE9	HPRD
CTND2_HUMAN	CTNND2	HPRD
D7RWZ3_HUMAN	GRIK2	HPRD
DAZP2_HUMAN	DAZAP2	BioGRID
DLG5_HUMAN	DLG5	HPRD
DLGP1_HUMAN	DLGAP1	BioGRID
DNJC8_HUMAN	DNAJC8	IntAct
DSC3_HUMAN	DSC3	HPRD
DVL1_HUMAN	DVL1	HPRD
DVL2_HUMAN	DVL2	BioGRID
DVL3_HUMAN	DVL3	HPRD
E1P556_HUMAN	FYN	BioGRID
E7ESE5	MUC1	BioGRID
E7EUG9	MUC1	BioGRID
E9PB45_HUMAN	DAZAP2	BioGRID
E9PDK3_HUMAN	LEF1	BioGRID
E9PE89_HUMAN	DAZAP2	BioGRID
E9PHA1_HUMAN	PCSK1	BioGRID
E9QMJ8_MOUSE	Axin1	BioGRID
EGFR_HUMAN	EGFR	HPRD
EMD_HUMAN	EMD	MINT
EPHA2_HUMAN	EPHA2	DIP
ERBB2_HUMAN	ERBB2	HPRD
ERMIN_HUMAN	ERMN	IntAct
ESR1_HUMAN	ESR1	HPRD
ESR2_HUMAN	ESR2	IntAct
EZH2_HUMAN	EZH2	BioGRID
EZRI_HUMAN	EZR	HPRD
F123B_HUMAN	FAM123B	BioGRID
F1D8N5_HUMAN	NR3C4	BioGRID
F1D8Q5_HUMAN	NR2B1	BioGRID
F1D8R8_HUMAN	NR5A1	HPRD
F1D8S2_HUMAN	NR2A1	BioGRID
F1D8T0_HUMAN	NR2A1	BioGRID
F1D8T1_HUMAN	NR2A1	BioGRID
FBW1A_HUMAN	BTRC	HPRD
FBW1B_HUMAN	FBXW11	BioGRID
FER_HUMAN	FER	HPRD
FHL2_HUMAN	FHL2	HPRD
FOXO3_HUMAN	FOXO3	BioGRID
FOXO4_HUMAN	FOXO4	BioGRID
FSCN1_HUMAN	FSCN1	HPRD
FYN_HUMAN	FYN	HPRD
GLIS2_HUMAN	GLIS2	HPRD
GNA13_HUMAN	GNA13	HPRD
GRIK2_HUMAN	GRIK2	HPRD
GSK3B_HUMAN	GSK3B	HPRD
H12_HUMAN	HIST1H1C	BioGRID
HDAC1_HUMAN	HDAC1	MINT
HDAC6_HUMAN	HDAC6	BioGRID
HDAC7_HUMAN	HDAC7	BioGRID
HIC1_HUMAN	HIC1	MINT
HNF1A_HUMAN	HNF1A	HPRD
HNF4A_HUMAN	HNF4A	BioGRID
IF2B1_HUMAN	IGF2BP1	HPRD
IKKA_HUMAN	CHUK	HPRD
IKKB_HUMAN	IKBKB	HPRD
ILVD_YERPE	ilvD	IntAct
IQGA1_HUMAN	IQGAP1	HPRD
ITF2_HUMAN	TCF4	HPRD
JADE1_HUMAN	PHF17	BioGRID
K1109_HUMAN	KIAA1109	IntAct
KAT2B_HUMAN	KAT2B	BioGRID
KC1A_HUMAN	CSNK1A1	HPRD
KC1D_HUMAN	CSNK1D	HPRD
LAP2_HUMAN	ERBB2IP	MINT
LEF1_HUMAN	LEF1	HPRD
LEG9_HUMAN	LGALS9	BioGRID
LEO1_HUMAN	LEO1	IntAct
LEUK_HUMAN	SPN	HPRD
LIMA1_MOUSE	Lima1	DIP
LMNA_HUMAN	LMNA	BioGRID
MAGI1_HUMAN	MAGI1	BioGRID
MAGI2_HUMAN	MAGI2	HPRD
MEN1_HUMAN	MEN1	BioGRID
MERL_HUMAN	NF2	HPRD
MET_HUMAN	MET	BioGRID
MITF_HUMAN	MITF	HPRD
MUC1_HUMAN	MUC1	BioGRID
MYO7A_HUMAN	MYO7A	BioGRID
NCOA2_HUMAN	NCOA2	HPRD
NDRG1_HUMAN	NDRG1	HPRD
NEC1_HUMAN	PCSK1	BioGRID
NEUL2_HUMAN	NEURL2	HPRD
NHRF1_HUMAN	SLC9A3R1	HPRD
NLK_HUMAN	NLK	BioGRID
NMDE4_HUMAN	GRIN2D	HPRD
NMDZ1_HUMAN	GRIN1	HPRD
P85A_HUMAN	PIK3R1	HPRD
PARD3_HUMAN	PARD3	MINT
PDIP3_HUMAN	POLDIP3	String
PECA1_HUMAN	PECAM1	BioGRID
PHB2_HUMAN	PHB2	BioGRID
PICK1_HUMAN	PICK1	HPRD
PIN1_HUMAN	PIN1	HPRD
PITX2_HUMAN	PITX2	HPRD
PKD1_HUMAN	PKD1	HPRD
PKP2_HUMAN	PKP2	HPRD
PKP4_HUMAN	PKP4	MINT
PPAC_HUMAN	ACP1	HPRD
PROP1_HUMAN	PROP1	BioGRID
PSN1_HUMAN	PSEN1	BioGRID
PTN11_HUMAN	PTPN11	BioGRID
PTN12_HUMAN	PTPN12	IntAct
PTN13_HUMAN	PTPN13	HPRD
PTN14_HUMAN	PTPN14	HPRD
PTN1_HUMAN	PTPN1	HPRD
PTN6_HUMAN	PTPN6	HPRD
PTN_HUMAN	PTN	BioGRID
PTPRB_HUMAN	PTPRB	IntAct
PTPRC_HUMAN	PTPRC	IntAct
PTPRF_HUMAN	PTPRF	HPRD
PTPRG_HUMAN	PTPRG	IntAct
PTPRJ_HUMAN	PTPRJ	HPRD
PTPRK_HUMAN	PTPRK	BioGRID
PTPRM_HUMAN	PTPRM	HPRD
PTPRO_HUMAN	PTPRO	IntAct
PTPRU_HUMAN	PTPRU	HPRD
PTPRZ_HUMAN	PTPRZ1	HPRD
PYGO1_HUMAN	PYGO1	HPRD
Q05DA5_HUMAN	FER	HPRD
Q0VAP5_HUMAN	MUC1	BioGRID
Q0VAP6_HUMAN	MUC1	BioGRID
Q14DJ8_MOUSE	Axin1	BioGRID
Q2TB39_HUMAN	TCF3	HPRD
Q2XQU9_HUMAN	_	BioGRID
Q3B8N1_HUMAN	LGALS9	BioGRID
Q4LE28_HUMAN	CREBBP	HPRD
Q4LE70_HUMAN	APC	HPRD
Q53XR6_HUMAN	SMAD2	HPRD
Q59EH3_HUMAN	_	HPRD
Q59EZ1_HUMAN	_	HPRD
Q59G17_HUMAN	_	HPRD
Q5NEM9_FRATT	FTT_1597	IntAct
Q5T4V2_HUMAN	CTNNBIP1	HPRD
Q5T7S2_HUMAN	TGFBR1	HPRD
Q5TAV5_HUMAN	TFAP2A	BioGRID
Q5W141_HUMAN	BTRC	HPRD
Q659G9_HUMAN	DKFZp586H0919	HPRD
Q6FHW4_HUMAN	TCF7L2	HPRD
Q6FI00_HUMAN	CCND1	HPRD
Q6FI27_HUMAN	GSK3B	BioGRID
Q6I9R8_HUMAN	FHL2	HPRD
Q6P3U7_HUMAN	RXRA	BioGRID
Q6P468_HUMAN	USP9X	HPRD
Q6P4H4_HUMAN	_	BioGRID
Q6PJ06_HUMAN	CSNK1A1	HPRD
Q7CIP7_YERPE	nifJ	IntAct
Q7Z538_HUMAN	MUC1	BioGRID
Q7Z550_HUMAN	MUC1	BioGRID
Q7Z551_HUMAN	MUC1	BioGRID
Q86T64_HUMAN	DKFZp451F1115	HPRD
Q86WJ2_HUMAN	PTPRK	BioGRID
Q86X58_HUMAN	USP9X	BioGRID
Q8CIW2	_	MINT
Q8CZR8_YERPE	y3527	IntAct
Q8D015_YERPE	y2968	IntAct
Q8IY40_HUMAN	GRIK2	HPRD
Q8N1C6_HUMAN	TFAP2A	BioGRID
Q8N619_HUMAN	CDK5R1	HPRD
Q96DN7_HUMAN	BOC	BioGRID
Q9GZQ5_HUMAN	MEN1	BioGRID
Q9HBD4_HUMAN	SMARCA4	HPRD
Q9NPR5_HUMAN	_	HPRD
Q9NUA2_HUMAN	_	HPRD
Q9P0T0_HUMAN	_	HPRD
Q9UII7_HUMAN	_	HPRD
Q9UK67_HUMAN	_	HPRD
Q9Y1T2_DROME	Apc2	BioGRID
RAB8B_HUMAN	RAB8B	BioGRID
RDGC_YERPE	rdgC	IntAct
RHG32_HUMAN	ARHGAP32	HPRD
RL21_HUMAN	RPL21	IntAct
RPGF2_HUMAN	RAPGEF2	HPRD
RUNX3_HUMAN	RUNX3	IntAct
RUVB1_HUMAN	RUVBL1	HPRD
RUVB2_HUMAN	RUVBL2	BioGRID
RXRA_HUMAN	RXRA	BioGRID
SATB1_HUMAN	SATB1	DIP
SH3K1_HUMAN	SH3KBP1	IntAct
SMAD2_HUMAN	SMAD2	HPRD
SMAD3_HUMAN	SMAD3	HPRD
SMAD4_HUMAN	SMAD4	HPRD
SMAD7_HUMAN	SMAD7	BioGRID
SMCA4_HUMAN	SMARCA4	BioGRID
SOX17_HUMAN	SOX17	HPRD
SOX6_HUMAN	SOX6	BioGRID
SRC_HUMAN	SRC	HPRD
STF1_HUMAN	NR5A1	HPRD
TAD2A_HUMAN	TADA2A	BioGRID
TADA3_HUMAN	TADA3	BioGRID
TBL1X_HUMAN	TBL1X	HPRD
TCF7_HUMAN	TCF7	MINT
TF7L1_HUMAN	TCF7L1	HPRD
TF7L2_HUMAN	TCF7L2	BioGRID
TFE2_HUMAN	TCF3	HPRD
TGFR1_HUMAN	TGFBR1	HPRD
TLE1_HUMAN	TLE1	BioGRID
TNR6B_HUMAN	TNRC6B	IntAct
TOB1_HUMAN	TOB1	BioGRID
TOP2A_HUMAN	TOP2A	IntAct
UBC_HUMAN	UBC	BioGRID
USP9X_HUMAN	USP9X	HPRD
VEZA_HUMAN	VEZT	BioGRID
VGFR1_HUMAN	FLT1	HPRD
VGFR2_HUMAN	KDR	HPRD
ZFYV9_HUMAN	ZFYVE9	MINT

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