The results suggest that deregulation of the expression of the apoptosis inhibitor Aven may be related to male factor infertility. Moreover, Aven is an estrogen target gene and may be involved in the mechanism of testicular apoptosis control by estrogens.
The information of related literatures
1. S. Laurentino, J. Goncalves, J. E. Cavaco, P. F. Oliveira, M. G. Alves, M. de Sousa, A. Barros and S. Socorro (2011) Apoptosis-inhibitor Aven is downregulated in defective spermatogenesis and a novel estrogen target gene in mammalian testis. Fertil Steril (): .
Endomembrane system; Peripheral membraneprotein. Note=Associated with intracellular membranes.
Tissue Specificity
Highly expressed in testis, ovary, thymus,prostate, spleen, small intestine, colon, heart, skeletal muscle,liver, kidney and pancreas.-----------------------------------------------------------------------Copyrighted by the UniProt Consortium, see http://www.uniprot.org/termsDistributed under the Creative Commons Attribution-NoDerivs License-----------------------------------------------------------------------
CHAIN 1 362 Cell death regulator Aven. /FTId=PRO_0000064768. COMPBIAS 5 85 Ala/Gly-rich. MOD_RES 94 94 Phosphoserine. VARIANT 228 228 Q -> R (in dbSNP:rs2241647). /FTId=VAR_020144. Back to Top