SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000609 
UniProt Accession
Theoretical PI
4.43  
Molecular Weight
99809 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
CDH2 
Gene Synonyms/Alias
CDHN, NCAD 
Protein Name
Cadherin-2 
Protein Synonyms/Alias
CDw325; Neural cadherin;N-cadherin CD_antigen=CD325;Flags: Precursor 
Organism
Homo sapiens (Human) 
NCBI Taxonomy ID
9606 
Chromosome Location
chr:18;25530930-25757410;-1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
observations indicate that cadherins play an important role in the organization of the seminiferous and epididymal epithelium. 
The information of related literatures
1. A. M. Andersson, K. Edvardsen and N. E. Skakkebaek (1994) Expression and localization of N- and E-cadherin in the human testis and epididymis. Int J Androl 17(4): 174-80. 

Abstract
Cellular interactions in the testis and epididymis are an important prerequisite for spermatogenesis and sperm maturation, and involve a well-developed complex of intercellular junctions. Cadherins are cell surface proteins which mediate intercellular Ca(2+)-dependent adhesion and are believed to be fundamentally important for maintaining multicellular structures. In the present study we report the expression of a 135 kDa N-cadherin polypeptide in the human seminiferous epithelium by immunoblotting. The presence of N-cadherin was demonstrated by immunohistochemistry on the surface of spermatogonia and primary spermatocytes, and possibly also around some early spermatids, whereas late spermatids were always negative. Endothelial cells also stained for N-cadherin, whereas peritubular cells and Leydig cells did not. No expression of E-cadherin could be demonstrated in the human testis. In the human epididymis E-cadherin, but not N-cadherin, was expressed and localized to the surface of the principal epithelial cells as shown by immunohistochemistry. These observations indicate that cadherins play an important role in the organization of the seminiferous and epididymal epithelium. PMID: [7995652] 

Back to Top
Figures for illustrating the function of this protein/gene
Function
Cadherins are calcium-dependent cell adhesion proteins.They preferentially interact with themselves in a homophilicmanner in connecting cells; cadherins may thus contribute to thesorting of heterogeneous cell types. CDH2 may be involved inneuronal recognition mechanism. In hippocampal neurons, mayregulate dendritic spine density (By similarity). 
Back to Top
Subcellular Location
Cell membrane; Single-pass type I membraneprotein. 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0016342 C:catenin complex IDA:BHF-UCL.
GO:0005913 C:cell-cell adherens junction IDA:BHF-UCL.
GO:0005916 C:fascia adherens IEA:Compara.
GO:0016021 C:integral to membrane IEA:UniProtKB-KW.
GO:0014704 C:intercalated disc ISS:BHF-UCL.
GO:0030027 C:lamellipodium IEA:Compara.
GO:0005624 C:membrane fraction IEA:Compara.
GO:0044456 C:synapse part IEA:Compara.
GO:0005509 F:calcium ion binding IEA:InterPro.
GO:0034332 P:adherens junction organization TAS:Reactome.
GO:0048514 P:blood vessel morphogenesis IEA:Compara.
GO:0016339 P:calcium-dependent cell-cell adhesion IEA:Compara.
GO:0007155 P:cell adhesion TAS:ProtInc.
GO:0034329 P:cell junction assembly TAS:Reactome.
GO:0016477 P:cell migration IEA:Compara.
GO:0007157 P:heterophilic cell-cell adhesion IEA:Compara.
GO:0007156 P:homophilic cell adhesion IEA:Compara.
GO:0042692 P:muscle cell differentiation TAS:Reactome.
GO:0090090 P:negative regulation of canonical Wnt receptor signaling pathway IEA:Compara.
GO:0043410 P:positive regulation of MAPK cascade IEA:Compara.
GO:0051149 P:positive regulation of muscle cell differentiation TAS:Reactome.
GO:0050770 P:regulation of axonogenesis IEA:Compara.
GO:0031641 P:regulation of myelination IEA:Compara.
GO:0032880 P:regulation of protein localization IEA:Compara.
GO:0035023 P:regulation of Rho protein signal transduction IEA:Compara.
GO:0051146 P:striated muscle cell differentiation IEA:Compara.
GO:0007416 P:synapse assembly IEA:Compara.
Back to Top
Interpro
IPR002126;    Cadherin.
IPR015919;    Cadherin-like.
IPR020894;    Cadherin_CS.
IPR000233;    Cadherin_cytoplasmic-dom.
IPR014868;    Cadherin_pro_dom.
IPR009124;    Desmocollin.
Back to Top
Pfam
PF00028;    Cadherin;    5.
PF01049;    Cadherin_C;    1.
PF08758;    Cadherin_pro;    1.
Back to Top
SMART
SM00112;    CA;    5.
SM01055;    Cadherin_pro;    1.
Back to Top
PROSITE
PS00232;    CADHERIN_1;    3.
PS50268;    CADHERIN_2;    5.
Back to Top
PRINTS
PR00205;    CADHERIN.;   
PR01820;    DESMOCOLLIN.;   
Back to Top
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
SIGNAL        1     25       Potential.
PROPEP       26    159
                             /FTId=PRO_0000003731.
CHAIN       160    906       Cadherin-2.
                             /FTId=PRO_0000003732.
TOPO_DOM    160    724       Extracellular (Potential).
TRANSMEM    725    745       Helical; (Potential).
TOPO_DOM    746    906       Cytoplasmic (Potential).
DOMAIN      160    267       Cadherin 1.
DOMAIN      268    382       Cadherin 2.
DOMAIN      383    497       Cadherin 3.
DOMAIN      498    603       Cadherin 4.
DOMAIN      604    714       Cadherin 5.
COMPBIAS    863    878       Ser-rich.
MOD_RES     785    785       Phosphotyrosine.
CARBOHYD    190    190       N-linked (GlcNAc...) (Potential).
CARBOHYD    273    273       N-linked (GlcNAc...).
CARBOHYD    325    325       N-linked (GlcNAc...) (Potential).
CARBOHYD    402    402       N-linked (GlcNAc...).
CARBOHYD    572    572       N-linked (GlcNAc...).
CARBOHYD    651    651       N-linked (GlcNAc...) (Potential).
CARBOHYD    692    692       N-linked (GlcNAc...).
VARIANT      21     21       A -> T (in dbSNP:rs17495042).
                             /FTId=VAR_028254.
VARIANT     118    118       A -> T (in dbSNP:rs17445840).
                             /FTId=VAR_028255.
VARIANT     196    196       S -> T (in dbSNP:rs1041970).
                             /FTId=VAR_028256.
VARIANT     212    212       I -> L (in dbSNP:rs1041972).
                             /FTId=VAR_028257.
VARIANT     454    454       T -> A (in dbSNP:rs17857112).
                             /FTId=VAR_048503.
VARIANT     845    845       N -> S (in dbSNP:rs2289664).
                             /FTId=VAR_028258.
CONFLICT     12     12       Missing (in Ref. 3; AAB22854).
CONFLICT     16     16       A -> L (in Ref. 1; CAA38213).
CONFLICT    164    164       P -> S (in Ref. 6; AAH36470).
CONFLICT    357    357       N -> I (in Ref. 1; CAA38213).
CONFLICT    437    437       P -> Q (in Ref. 6; AAH36470).
CONFLICT    484    484       V -> M (in Ref. 6; AAH36470).
CONFLICT    629    629       D -> G (in Ref. 6; AAH36470).
CONFLICT    867    867       A -> L (in Ref. 3; AAB22854).
Back to Top
Nucleotide Sequence
Length: 2853 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 906 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
_HPRD 
PTPN1HPRD 
ARVCFHPRD 
_HPRD 
BOCHPRD 
CDH11HPRD 
ACTA1BioGRID 
_BioGRID 
CDH11BioGRID 
CREBBPHPRD 
CTNNA1BioGRID 
CTNNB1BioGRID 
CTNND1BioGRID 
CTNND2HPRD 
GNA12BioGRID 
GNA13BioGRID 
JUPBioGRID 
PTPN1MINT 
PTPN7DIP 
CREBBPHPRD 
_BioGRID 
CDH4HPRD 
CDONHPRD 
CTNNA1HPRD 
CTNNB1HPRD 
GRIK2HPRD 
FGFR4HPRD 
GNA12HPRD 
GNA13HPRD 
GRIK2HPRD 
PRKAR1AIntAct 
LRRC7HPRD 
GRIN2DHPRD 
GRIN1HPRD 
PIK3R1HPRD 
PKP4BioGRID 
JUPHPRD 
PTPN12IntAct 
PTPN1HPRD 
PTPN22IntAct 
PTPN6IntAct 
PTPN7IntAct 
PTPRBIntAct 
PTPRCIntAct 
PTPRGIntAct 
PTPRJIntAct 
PTPRKIntAct 
PTPROIntAct 
PTPRRIntAct 
_HPRD 
_HPRD 
DKFZp451F1115HPRD 
GRIK2HPRD 
BOCBioGRID 
RAB8BBioGRID 
ARHGAP32HPRD 
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
Comments