SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000631 
UniProt Accession
Theoretical PI
9.37  
Molecular Weight
80786 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
MTA1 
Gene Synonyms/Alias
 
Protein Name
Metastasis-associated protein MTA1 
Protein Synonyms/Alias
 
Organism
Homo sapiens (Human) 
NCBI Taxonomy ID
9606 
Chromosome Location
chr:14;105886157-105937066;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
The present communication initially provides new evidence for the potential role of MTA1 in mature testis. In addition, its distinctive expression in germ cells suggests a regulatory role of the peptide during spermatogenes. 
The information of related literatures
1. W. Li, X. P. Liu, R. J. Xu and Y. Q. Zhang (2007) Immunolocalization assessment of metastasis-associated protein 1 in human and mouse mature testes and its association with spermatogenesis. Asian J Androl 9(3): 345-52. 

Abstract
AIM PMID: [17486275] 

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Figures for illustrating the function of this protein/gene
Ref: W. Li, X. P. Liu, R. J. Xu and Y. Q. Zhang (2007) Immunolocalization assessment of metastasis-associated protein 1 in human and mouse mature testes and its association with spermatogenesis. Asian J Androl 9(3): 345-52. PMID: [17486275]
Ref: W. Li, X. P. Liu, R. J. Xu and Y. Q. Zhang (2007) Immunolocalization assessment of metastasis-associated protein 1 in human and mouse mature testes and its association with spermatogenesis. Asian J Androl 9(3): 345-52. PMID: [17486275]
Ref: W. Li, X. P. Liu, R. J. Xu and Y. Q. Zhang (2007) Immunolocalization assessment of metastasis-associated protein 1 in human and mouse mature testes and its association with spermatogenesis. Asian J Androl 9(3): 345-52. PMID: [17486275]
Function
May be involved in the regulation of gene expression bycovalent modification of histone proteins. Isoform Long is acorepressor of estrogen receptor (ER). Isoform Short binds to ERand sequesters it in the cytoplasm and enhances non-genomicresponses of ER. 
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Subcellular Location
Isoform Long: Nucleus. 
Tissue Specificity
Widely expressed. High expression in brain,ovaries, adrenal glands and virgin mammary glands. Higher intumors than in adjacent normal tissue from the same individual. 
Gene Ontology
GO IDGO termEvidence
GO:0005737 C:cytoplasm IDA:HPA.
GO:0005634 C:nucleus IDA:HPA.
GO:0016581 C:NuRD complex IEA:Compara.
GO:0043565 F:sequence-specific DNA binding IEA:InterPro.
GO:0003700 F:sequence-specific DNA binding transcription factor activity IEA:InterPro.
GO:0008270 F:zinc ion binding IEA:InterPro.
GO:0007165 P:signal transduction TAS:ProtInc.
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Interpro
IPR001025;    BAH_dom.
IPR000949;    ELM2_dom.
IPR009057;    Homeodomain-like.
IPR001005;    SANT/Myb.
IPR017884;    SANT_dom.
IPR000679;    Znf_GATA.
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Pfam
PF01426;    BAH;    1.
PF01448;    ELM2;    1.
PF00320;    GATA;    1.
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SMART
SM00439;    BAH;    1.
SM00717;    SANT;    1.
SM00401;    ZnF_GATA;    1.
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PROSITE
PS51038;    BAH;    1.
PS51156;    ELM2;    1.
PS00344;    GATA_ZN_FINGER_1;    FALSE_NEG.
PS50114;    GATA_ZN_FINGER_2;    FALSE_NEG.
PS51293;    SANT;    1.
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PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1    715       Metastasis-associated protein MTA1.
                             /FTId=PRO_0000083493.
DOMAIN        1    164       BAH.
DOMAIN      165    276       ELM2.
DOMAIN      283    335       SANT.
ZN_FING     393    420       GATA-type; atypical.
MOTIF       545    552       SH3-binding (Potential).
MOTIF       696    705       SH3-binding (Potential).
COMPBIAS    697    705       Poly-Pro.
MOD_RES     386    386       Phosphoserine.
MOD_RES     449    449       Phosphoserine.
MOD_RES     467    467       Phosphothreonine.
MOD_RES     520    520       Phosphoserine.
MOD_RES     522    522       Phosphoserine.
MOD_RES     564    564       Phosphothreonine.
MOD_RES     576    576       Phosphoserine.
MOD_RES     578    578       Phosphothreonine.
VAR_SEQ      64     81       TLSVCYKAGPGADNGEEG -> R (in isoform 3).
                             /FTId=VSP_042207.
VAR_SEQ     398    430       TTQSYQWYSWGPPNMQCRLCASCWTYWKKYGGL -> MSSL
                             RILLDILEEIWWLENANPVRWREARTKPQ (in isoform
                             Short).
                             /FTId=VSP_001601.
VAR_SEQ     431    715       Missing (in isoform Short).
                             /FTId=VSP_001602.
VARIANT     372    372       V -> I (in dbSNP:rs4983413).
                             /FTId=VAR_055847.
VARIANT     612    612       A -> T (in dbSNP:rs13707).
                             /FTId=VAR_058965.
CONFLICT    498    498       H -> N (in Ref. 1; AAA78935).
CONFLICT    545    545       P -> R (in Ref. 5; AAI42942).
CONFLICT    655    655       D -> G (in Ref. 1; AAA78935).
CONFLICT    661    662       AT -> PK (in Ref. 1; AAA78935).
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Nucleotide Sequence
Length: 2640 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 715 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
ATRBioGRID 
_BioGRID 
BCL11ABioGRID 
BCL11BBioGRID 
CCNHHPRD 
CDK7BioGRID 
ITGB3BPHPRD 
HIF1AHPRD 
BCL11ABioGRID 
BCL11ABioGRID 
DDX18HPRD 
ESR1BioGRID 
ZFPM2BioGRID 
FOXP1BioGRID 
GPR183HPRD 
HDAC1BioGRID 
HDAC2BioGRID 
HIF1AHPRD 
HSF1BioGRID 
CSNK1G2BioGRID 
KDM1AIntAct 
LMO4BioGRID 
MNAT1BioGRID 
MBD3L1BioGRID 
MBD3L2BioGRID 
SPENString 
GRB2HPRD 
_BioGRID 
_BioGRID 
BCL11BBioGRID 
ITGB3BPBioGRID 
CHD3BioGRID 
CHD4BioGRID 
HIF1ABioGRID 
DDX18IntAct 
DYNLL1HPRD 
CHD3BioGRID 
EP300BioGRID 
ESR1HPRD 
GPR183IntAct 
GRB2HPRD 
HDAC1HPRD 
HDAC2BioGRID 
HIF1ABioGRID 
HSF1BioGRID 
CSNK1G2BioGRID 
LMO4BioGRID 
MNAT1HPRD 
SPENString 
MTA1BioGRID 
MTA1BioGRID 
MTA2BioGRID 
TH1LHPRD 
TP53HPRD 
CHD4BioGRID 
CHD3BioGRID 
_HPRD 
RBBP7BioGRID 
DNCL1HPRD 
RBBP7BioGRID 
HDAC1HPRD 
EP300BioGRID 
_BioGRID 
_BioGRID 
RBBP4HPRD 
RBBP7BioGRID 
SH3GLB1HPRD 
SIN3ABioGRID 
MTA2BioGRID 
NAA10BioGRID 
TH1LBioGRID 
TP53BioGRID 
PARK7IntAct 
_BioGRID 
FOXP1BioGRID 
HDAC1BioGRID 
_HPRD 
_BioGRID 
FOXP1BioGRID 
_BioGRID 
_BioGRID 
SUMO2BioGRID 
tatBioGRID 
ZEB2BioGRID 
Other Protein-Protein interaction resources
String database  
View Microarray data
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