Tag Content
SG ID
SG00000664 
UniProt Accession
Theoretical PI
11.36  
Molecular Weight
11367 Da  
Genbank Nucleotide ID
Genbank Protein ID
CAA24918.1; AAA52652.1; AAA63188.1; CAA43011.1; CAA43012.1; CAA43013.1; CAA43014.1; CAA43016.1; CAA43017.1; CAA47464.1; CAB02549.1; CAA58538.1; AAM83108.1; AAN01438.1; AAN01439.1; AAN01440.1; AAN01441.1; AAN01442.1; AAN01443.1; AAN01444.1; AAN01446.1; AAN01447.1; AAN01448.1; AAN01449.1; AAN01450.1; BAA19208.1; AAT68253.1; CAG46966.1; CAG46969.1; CAG46977.1; CAG46984.1; CAG46986.1; CAA16946.1; CAC69642.1; CAC03414.1; CAC03418.1; CAC03426.1; CAC03427.1; CAC04128.1; CAD24074.1; CAI12560.1; CAI12567.1; EAW55509.1; EAW55510.1; EAW55538.1; EAW55549.1; EAW55555.1; EAW96325.1; EAX03086.1; EAX03111.1; EAX03112.1; EAX03121.1; AAH17361.1; AAH54014.1; AAH66248.1; AAH66249.1; AAH66250.1; AAH67495.1; AAH67496.1; AAH67497.1; AAH69288.1; AAH69392.1; AAH69467.1; AAH69654.1; AAH93763.1; AAH93765.1; AAH93969.1; AAI11094.1; AAI11435.1; AAI12194.1; AAI20940.1; AAI28105.1; AAI28106.1; AAI30559.1; AAI30561.1; AAI43046.1
Gene Name
HIST4H4 
Gene Synonyms/Alias
 
Protein Name
Histone H4 
Protein Synonyms/Alias
 
Organism
Homo sapiens (Human) 
NCBI Taxonomy ID
9606 
Chromosome Location
chr:12;14920933-14924065;-1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
The reduced percentage of spermatogonia with Hypac-H4 and Lys12ac-H4 in groups B and C may contribute to lower sperm production in mixed atrophy. Spermatids Hypac-H4 impairment in mixed atrophy did not deteriorate further by AZFc region deletion. 
The information of related literatures
1. S. E. Kleiman, B. Bar-Shira Maymon, R. Hauser, A. Botchan, G. Paz, H. Yavetz and L. Yogev (2008) Histone H4 acetylation and AZFc involvement in germ cells of specimens of impaired spermatogenesis. Fertil Steril 89(6): 1728-36. 

Abstract
OBJECTIVE PMID: [18001726] 

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Figures for illustrating the function of this protein/gene
Function
Core component of nucleosome. Nucleosomes wrap andcompact DNA into chromatin, limiting DNA accessibility to thecellular machineries which require DNA as a template. Histonesthereby play a central role in transcription regulation, DNArepair, DNA replication and chromosomal stability. DNAaccessibility is regulated via a complex set of post-translationalmodifications of histones, also called histone code, andnucleosome remodeling. 
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Subcellular Location
Nucleus. Chromosome. 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0005576 C:extracellular region TAS:Reactome.
GO:0005654 C:nucleoplasm TAS:Reactome.
GO:0000786 C:nucleosome TAS:UniProtKB.
GO:0003677 F:DNA binding TAS:UniProtKB.
GO:0034080 P:CenH3-containing nucleosome assembly at centromere TAS:Reactome.
GO:0045653 P:negative regulation of megakaryocyte differentiation IDA:UniProtKB.
GO:0048015 P:phosphatidylinositol-mediated signaling NAS:UniProtKB.
GO:0000723 P:telomere maintenance TAS:Reactome.
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Interpro
IPR009072;    Histone-fold.
IPR007125;    Histone_core_D.
IPR001951;    Histone_H4.
IPR019809;    Histone_H4_CS.
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Pfam
PF00125;    Histone;    1.
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SMART
SM00417;    H4;    1.
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PROSITE
PS00047;    HISTONE_H4;    1.
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PRINTS
PR00623;    HISTONEH4.;   
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Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
INIT_MET      1      1       Removed.
CHAIN         2    103       Histone H4.
                             /FTId=PRO_0000158320.
DNA_BIND     17     21
MOD_RES       2      2       N-acetylserine.
MOD_RES       2      2       Phosphoserine.
MOD_RES       4      4       Asymmetric dimethylarginine; by PRMT1;
                             alternate.
MOD_RES       4      4       Citrulline; alternate.
MOD_RES       4      4       Omega-N-methylarginine; by PRMT1;
                             alternate.
MOD_RES       4      4       Symmetric dimethylarginine; by PRMT5 and
                             PRMT7; alternate (By similarity).
MOD_RES       6      6       N6-acetyllysine.
MOD_RES       9      9       N6-acetyllysine.
MOD_RES      13     13       N6-acetyllysine.
MOD_RES      17     17       N6-acetyllysine.
MOD_RES      21     21       N6,N6,N6-trimethyllysine; alternate.
MOD_RES      21     21       N6,N6-dimethyllysine; alternate.
MOD_RES      21     21       N6-methyllysine; alternate.
MOD_RES      32     32       N6-acetyllysine.
MOD_RES      48     48       Phosphoserine; by PAK2.
MOD_RES      52     52       Phosphotyrosine.
MOD_RES      60     60       N6-acetyllysine.
MOD_RES      80     80       N6-acetyllysine.
MOD_RES      89     89       Phosphotyrosine.
MOD_RES      92     92       N6-acetyllysine; alternate.
CROSSLNK     92     92       Glycyl lysine isopeptide (Lys-Gly)
                             (interchain with G-Cter in ubiquitin);
                             alternate.
VARIANT      64     64       E -> Q (in a breast cancer sample;
                             somatic mutation).
                             /FTId=VAR_036206.
CONFLICT     71     71       V -> A (in Ref. 14; AAH67496).
CONFLICT     77     77       A -> P (in Ref. 11; CAG46986).
STRAND       21     23
HELIX        27     29
HELIX        32     41
HELIX        51     76
STRAND       80     82
HELIX        84     91
STRAND       98    101
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Nucleotide Sequence
Length: 727 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 103 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
Gene Symbol Ref Databases
YWHAZMINT 
BRD2BioGRID 
MYST3BioGRID 
MSL3BioGRID 
MSL3BioGRID 
PRMT5BioGRID 
PRMT11IntAct 
PRMT12IntAct 
PRMT1HPRD 
PRMT5BioGRID 
Prmt5IntAct 
PRMT6BioGRID 
PRMT7BioGRID 
ARRB1IntAct 
ASF1AHPRD 
ASF1BHPRD 
H3F3ABioGRID 
_BioGRID 
_BioGRID 
_BioGRID 
_BioGRID 
_BioGRID 
_BioGRID 
_BioGRID 
_BioGRID 
_BioGRID 
_BioGRID 
_BioGRID 
NR1H4BioGRID 
_BioGRID 
_BioGRID 
_BioGRID 
_BioGRID 
_BioGRID 
BAZ1BBioGRID 
BAZ2ABioGRID 
BRCA1MINT 
BRD2HPRD 
BRD4BioGRID 
BRD7MINT 
KAT5HPRD 
HDAC9BioGRID 
CALCOCO1BioGRID 
CREBBPBioGRID 
CBX5BioGRID 
CBX7BioGRID 
CDY1HPRD 
CENPABioGRID 
COPR5BioGRID 
CTNNBL1BioGRID 
CTDP1BioGRID 
CXXC1BioGRID 
DAXXBioGRID 
DEKBioGRID 
DNMT3LBioGRID 
DTX3LBioGRID 
DYRK1ABioGRID 
MYST2BioGRID 
HDAC9BioGRID 
CALCOCO1BioGRID 
NCOR1BioGRID 
HDAC9BioGRID 
EID1BioGRID 
EP300BioGRID 
ERCC6BioGRID 
ESR2IntAct 
GABARAPIntAct 
GABARAPL1IntAct 
GRB2IntAct 
H2AFXBioGRID 
HIST3H3BioGRID 
HIST1H3ABioGRID 
H3F3ABioGRID 
MCM7BioGRID 
CUL4BIntAct 
CASP7IntAct 
_BioGRID 
CUL4AIntAct 
ANP32ABioGRID 
ASF1ABioGRID 
MCM5BioGRID 
DNAJC9BioGRID 
_BioGRID 
_BioGRID 
_BioGRID 
_IntAct 
_BioGRID 
BRD7HPRD 
BRDTHPRD 
TP73IntAct 
CASP7IntAct 
CCNA2IntAct 
CENPAHPRD 
COPR5MINT 
CUL4AIntAct 
CUL4BIntAct 
DAXXBioGRID 
DEKBioGRID 
DNAJA2IntAct 
DNAJC9BioGRID 
CUL4BIntAct 
EID1BioGRID 
EP300BioGRID 
ERCC6BioGRID 
FKBP14BioGRID 
GADD45AHPRD 
HIST1H1EIntAct 
HIST1H3ADIP 
HAT1BioGRID 
HDAC8HPRD 
KDM4AMINT 
L3MBTL1IntAct 
MAP3K1IntAct 
MAP3K3IntAct 
MCM2BioGRID 
MCM3BioGRID 
MCM4BioGRID 
MCM5BioGRID 
MCM6BioGRID 
MCM7BioGRID 
NASPIntAct 
NCOR2BioGRID 
NPM1IntAct 
NUTMINT 
MAP3K7IntAct 
PHF20L1MINT 
GATAD2ABioGRID 
GATAD2BBioGRID 
TP73IntAct 
PAK1HPRD 
PHF20MINT 
PTMAHPRD 
UHRF1HPRD 
_BioGRID 
RBBP7BioGRID 
CASP7IntAct 
CASP7IntAct 
GADD45AHPRD 
SETHPRD 
RBBP7BioGRID 
EP300BioGRID 
RAD51L1HPRD 
RBBP4HPRD 
RBBP7BioGRID 
RB1IntAct 
SAP30HPRD 
SETD8IntAct 
SETHPRD 
SfmbtMINT 
SMARCA5BioGRID 
TAF1ABioGRID 
TAF1BBioGRID 
TBL1XR1HPRD 
TBL1XHPRD 
TNFRSF1AIntAct 
TP53BP1MINT 
UBE2IHPRD 
UBCBioGRID 
UHRF1HPRD 
HAT1IntAct 
HDAC1IntAct 
HDAC3BioGRID 
HDAC4IntAct 
HDAC5IntAct 
HDAC6IntAct 
HDAC9BioGRID 
HIRIP3HPRD 
HJURPIntAct 
ING1BioGRID 
ING2HPRD 
KAT2ABioGRID 
KAT2BBioGRID 
KAT5BioGRID 
MYST3BioGRID 
MYST2BioGRID 
MYST1BioGRID 
RPS6KA5HPRD 
LIN37IntAct 
LIN54IntAct 
L3MBTL1HPRD 
MAP3K1MINT 
MAP3K3MINT 
MCM2BioGRID 
MCM3IntAct 
MCM5IntAct 
MCM6DIP 
MSL3BioGRID 
NASPBioGRID 
NCOA3BioGRID 
NCOR1BioGRID 
NCOR2BioGRID 
NAP1L4HPRD 
NPM1BioGRID 
NR1H4BioGRID 
MAP3K7MINT 
PHF20L1MINT 
PARP10BioGRID 
PELP1BioGRID 
BRD4BioGRID 
CREBBPBioGRID 
_BioGRID 
_BioGRID 
RBBP7BioGRID 
NASPBioGRID 
ING1BioGRID 
DKFZp686N0336BioGRID 
DKFZp313H139BioGRID 
GABARAPL2IntAct 
RBBP7BioGRID 
NCOR1BioGRID 
EP300BioGRID 
_BioGRID 
PRMT1HPRD 
NPM1BioGRID 
DKFZp586C1419HPRD 
RAD51L1MINT 
RBBP7BioGRID 
SETDB1BioGRID 
SETD7BioGRID 
pr-set7BioGRID 
SETD8BioGRID 
SIRT7BioGRID 
SfmbtMINT 
SMARCA5BioGRID 
SUV420H1BioGRID 
SUV420H2BioGRID 
TAF1BBioGRID 
TBL1XR1HPRD 
TBL1XBioGRID 
DNTTIP2BioGRID 
THAP7BioGRID 
TNFRSF1AMINT 
TP53BP1HPRD 
YY1BioGRID 
Uhrf1MINT 
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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