SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000709 
UniProt Accession
Theoretical PI
9.71  
Molecular Weight
23863 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
TCP10L 
Gene Synonyms/Alias
ORFNames=PRED77 
Protein Name
T-complex protein 10A homolog 2 
Protein Synonyms/Alias
T-complex protein 10A-2TCP10A-2 TCP10-like; 
Organism
Homo sapiens (Human) 
NCBI Taxonomy ID
9606 
Chromosome Location
chr:21;33948862-33957843;-1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
TCP10L might play crucially important roles in spermatogenesis through its interaction with DAPK-3. 
The information of related literatures
1. H. Yu, D. Jiang, Z. Guo, H. Saiyin, J. Guo, X. Wang and L. Yu (2005) TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3. Int J Androl 28(3): 163-70. 

Abstract
The human transcriptional factor T-complex protein 10 like (TCP10L) gene is expressed exclusively in the liver and testis. However, the function of TCP10L in the testis remains unknown. We examined the expression of TCP10L in human testis and found that TCP10L was expressed specifically in the nucleus of spermatogenic cells during spermatogenesis. In addition, we identified death associated protein kinase 3 (DAPK-3/ZIP kinase) as a binding partner for TCP10L by yeast two-hybrid screening, followed with immunoprecipitation and subcellular localization experiments. Mutagenesis study revealed that this interaction was dependant on the leucine zipper motif-containing region. The specific expression pattern of TCP10L and interaction with DAPK-3 implies that TCP10L might play crucially important roles in spermatogenesis through its interaction with DAPK-3. PMID: [15910542] 

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Figures for illustrating the function of this protein/gene
Ref: H. Yu, D. Jiang, Z. Guo, H. Saiyin, J. Guo, X. Wang and L. Yu (2005) TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3. Int J Androl 28(3): 163-70. PMID: [15910542]
Ref: H. Yu, D. Jiang, Z. Guo, H. Saiyin, J. Guo, X. Wang and L. Yu (2005) TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3. Int J Androl 28(3): 163-70. PMID: [15910542]
Ref: H. Yu, D. Jiang, Z. Guo, H. Saiyin, J. Guo, X. Wang and L. Yu (2005) TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3. Int J Androl 28(3): 163-70. PMID: [15910542]
Function
 
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Subcellular Location
Nucleus. 
Tissue Specificity
Expressed in the seminiferous tubules (atprotein level). Liver and testis. 
Gene Ontology
GO IDGO termEvidence
GO:0005634 C:nucleus IEA:UniProtKB-SubCell.
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Interpro
IPR026581;    TCP10_fam.
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Pfam
SMART
PROSITE
PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1    215       T-complex protein 10A homolog 2.
                             /FTId=PRO_0000072462.
REGION       75     96       Leucine-zipper.
COILED       69    110       Potential.
VARIANT     145    145       H -> R (in dbSNP:rs9622).
                             /FTId=VAR_016099.
VARIANT     194    194       R -> H (in dbSNP:rs16989521).
                             /FTId=VAR_049089.
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Nucleotide Sequence
Length: 957 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 215 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
IKBKGBioGRID 
MXD4HPRD 
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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