SG ID

SG00000718 

UniProt Accession

F7H5G4_MACMU;F7H5G4;  

Theoretical PI

5.32  

Molecular Weight

24766 Da  

Genbank Nucleotide ID

JV044711;  

Genbank Protein ID

AFI34782.1; 

Gene Name

LOC701579 

Gene Synonyms/Alias

UCHL1 

Protein Name

 

Protein Synonyms/Alias

SubName: Ubiquitin carboxyl-terminal hydrolase isozyme L1SubName: Uncharacterized protein 

Macaca mulatta (Rhesus macaque) 

9544 

Temporarily unavailable 

The information of related literatures

1. Y. Tokunaga, S. Imai, R. Torii and T. Maeda (1999) Cytoplasmic liberation of protein gene product 9.5 during the seasonal regulation of spermatogenesis in the monkey (Macaca fuscata). Endocrinology 140(4): 1875-83. 

Abstract
Primate spermatogenesis is distinguished by yet unidentified mechanisms to regulate its spermatogenetic activity. In contrast to the well documented hormonal regulators, the cellular events responsible for the regulation of the spermatogenesis has not been addressed. By using PGP 9.5-immunohistochemistry, our previous study demonstrated that the monkey spermatogonia are divided into two distinct sub-populations, i.e. cytoplasmic PGP 9.5-positive and cytoplasmic PGP 9.5-negative spermatogonia. By comparing the cytoplasmic expression of PGP 9.5 between the breeding and nonbreeding seasons of the Japanese monkey (Macaca fuscata) in association with PCNA labeling, the present study demonstrates that the cytoplasmic PGP 9.5-positive Ap spermatogonia significantly increases when the spermatogenetic activity declines in the nonbreeding season. An ultrastructural subcellular localization of PGP 9.5 suggests that the increase of the cytoplasmic PGP 9.5 expression is due to a liberation of PGP 9.5 molecule from the nucleus into the cytoplasm. The results provide a theoretical basis by which PGP 9.5 serves as a novel marker for spermatogonial subtypes, which will have further implications for future studies on spermatogenesis. The analysis using this novel marker suggests that the Ap spermatogonia is a key stage to regulate the amount of the sperm produced in response to the hormonal regulators, and the cytoplasmic liberation of PGP 9.5 may serve as a pivotal phenomenon that enables the fully restorable, transient suppression of spermatogenesis in primate. PMID: [10098527] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0005622	C:intracellular	IEA:InterPro.
GO:0004221	F:ubiquitin thiolesterase activity	IEA:InterPro.
GO:0006511	P:ubiquitin-dependent protein catabolic process	IEA:InterPro.

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Interpro

IPR001578;    Peptidase_C12.
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Pfam

PF01088;    Peptidase_C12;    1.
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SMART

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PROSITE

PS00140;    UCH_1;    1.
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PRINTS

PR00707;    UBCTHYDRLASE.;   
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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 223 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

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Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

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