phospholipase D family (PLD) isozymes are involved in the spermatogenesis of the mouse testis.
The information of related literatures
1. S. Kim, H. Kim, Y. Lee, J. W. Hyun, Y. H. Lee, M. K. Shin, S. Min do and T. Shin (2007) The expression and cellular localization of phospholipase D isozymes in the developing mouse testis. J Vet Sci 8(3): 209-12.
Abstract To examine the involvement of phospholipase D (PLD) isozymes in postnatal testis development, the expression of PLD1 and PLD2 was examined in the mouse testis at postnatal weeks 1, 2, 4, and 8 using Western blot analysis and immunohistochemistry. The expression of both PLD1 and PLD2 increased gradually with development from postnatal week 1 to 8. Immunohistochemically, PLD immunoreactivity was detected in some germ cells in the testis and interstitial Leydig cells at postnatal week 1. PLD was mainly detected in the spermatocytes and residual bodies of spermatids in the testis after 8 weeks after birth. The intense immunostaining of PLD in Leydig cells remained unchanged by postnatal week 8. These findings suggest that PLD isozymes are involved in the spermatogenesis of the mouse testis. PMID: [17679764]
Endoplasmic reticulum membrane; Single-passtype II membrane protein (By similarity).
Tissue Specificity
Expressed at higher level in brain than innon-nervous tissue. Probably highly expressed in neurons.Expressed in mature neurons of the forebrain and appears to beturned on at late stages of neurogenesis. Expressed during lateneuronal development in the forebrain.