SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000818 
UniProt Accession
Theoretical PI
5.53  
Molecular Weight
85471 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Ctnnb1 
Gene Synonyms/Alias
Catnb 
Protein Name
Catenin beta-1 
Protein Synonyms/Alias
Beta-catenin; 
Organism
Mus musculus (Mouse) 
NCBI Taxonomy ID
10090 
Chromosome Location
chr:9;120838334-120869625;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Beta-Catenin is a key mediator of the wingless-related MMTV integration site (WNT) pathway. WNTs are a family of secreted proteins involved in regulation of a variety ofdevelopmental processes, including determination of segment polarity during Drosophila larval development,axis specification in Xenopus, and differentiation of brain, kidney, and limb as well as reproductive tracts of male and female mice. Dysregulated wingless-related MMTV integration site/beta-catenin signaling in Sertoli cells inhibits their postnatal differentiation, resulting in increased germ cell apoptosis and infertility. 
The information of related literatures
1. P. S. Tanwar, T. Kaneko-Tarui, L. Zhang, P. Rani, M. M. Taketo and J. Teixeira (2010) Constitutive WNT/beta-catenin signaling in murine Sertoli cells disrupts their differentiation and ability to support spermatogenesis. Biol Reprod 82(2): 422-32. 

Abstract
Sertoli and germ cell interactions are essential for spermatogenesis and, thus, male fertility. Sertoli cells provide a specialized microenvironment for spermatogonial stem cells to divide, allowing both self-renewal and spermatogenesis. In the present study, we used mice with a conditional activated allele of the beta-catenin gene (Ctnnb1(tm1Mmt)(/+)) in Sertoli cells expressing Cre recombinase driven by the anti-Mullerian hormone (AMH; also known as Mullerian-inhibiting substance) type II receptor promoter (Amhr2(tm3(cre)Bhr)(/+)) to show that constitutively activated beta-catenin leads to their continuous proliferation and compromised differentiation. Compared to controls, Sertoli cells in mature mutant mice continue to express high levels of both AMH and glial cell-derived neurotrophic factor (GDNF), which normally are expressed only in immature Sertoli cells. We also show evidence that LiCl treatment, which activates endogenous nuclear beta-catenin activity, regulates both AMH and GDNF expression at the transcriptional level. The epididymides were devoid of sperm in the Amhr2(tm3(cre)Bhr)(/+);Ctnnb1(tm1Mmt)(/+) mice at all ages examined. We show that the mutant mice are infertile because of defective differentiation of germ cells and increased apoptosis, both of which are characteristic of GDNF overexpression in Sertoli cells. Constitutive activation of beta-catenin in Amhr2-null mice showed the same histology, suggesting that the phenotype was the result of persistent overexpression of GDNF. These results show that dysregulated wingless-related MMTV integration site/beta-catenin signaling in Sertoli cells inhibits their postnatal differentiation, resulting in increased germ cell apoptosis and infertility. PMID: [19794154] 

2.  


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Figures for illustrating the function of this protein/gene
Ref: P. S. Tanwar, T. Kaneko-Tarui, L. Zhang, P. Rani, M. M. Taketo and J. Teixeira (2010) Constitutive WNT/beta-catenin signaling in murine Sertoli cells disrupts their differentiation and ability to support spermatogenesis. Biol Reprod 82(2): 422-32. PMID: [19794154]
Ref: P. S. Tanwar, T. Kaneko-Tarui, L. Zhang, P. Rani, M. M. Taketo and J. Teixeira (2010) Constitutive WNT/beta-catenin signaling in murine Sertoli cells disrupts their differentiation and ability to support spermatogenesis. Biol Reprod 82(2): 422-32. PMID: [19794154]
Ref: P. S. Tanwar, T. Kaneko-Tarui, L. Zhang, P. Rani, M. M. Taketo and J. Teixeira (2010) Constitutive WNT/beta-catenin signaling in murine Sertoli cells disrupts their differentiation and ability to support spermatogenesis. Biol Reprod 82(2): 422-32. PMID: [19794154]
Ref: P. S. Tanwar, T. Kaneko-Tarui, L. Zhang, P. Rani, M. M. Taketo and J. Teixeira (2010) Constitutive WNT/beta-catenin signaling in murine Sertoli cells disrupts their differentiation and ability to support spermatogenesis. Biol Reprod 82(2): 422-32. PMID: [19794154]
Ref: P. S. Tanwar, T. Kaneko-Tarui, L. Zhang, P. Rani, M. M. Taketo and J. Teixeira (2010) Constitutive WNT/beta-catenin signaling in murine Sertoli cells disrupts their differentiation and ability to support spermatogenesis. Biol Reprod 82(2): 422-32. PMID: [19794154]
Ref: P. S. Tanwar, T. Kaneko-Tarui, L. Zhang, P. Rani, M. M. Taketo and J. Teixeira (2010) Constitutive WNT/beta-catenin signaling in murine Sertoli cells disrupts their differentiation and ability to support spermatogenesis. Biol Reprod 82(2): 422-32. PMID: [19794154]
Ref: P. S. Tanwar, T. Kaneko-Tarui, L. Zhang, P. Rani, M. M. Taketo and J. Teixeira (2010) Constitutive WNT/beta-catenin signaling in murine Sertoli cells disrupts their differentiation and ability to support spermatogenesis. Biol Reprod 82(2): 422-32. PMID: [19794154]
Ref: P. S. Tanwar, T. Kaneko-Tarui, L. Zhang, P. Rani, M. M. Taketo and J. Teixeira (2010) Constitutive WNT/beta-catenin signaling in murine Sertoli cells disrupts their differentiation and ability to support spermatogenesis. Biol Reprod 82(2): 422-32. PMID: [19794154]
Ref: P. S. Tanwar, T. Kaneko-Tarui, L. Zhang, P. Rani, M. M. Taketo and J. Teixeira (2010) Constitutive WNT/beta-catenin signaling in murine Sertoli cells disrupts their differentiation and ability to support spermatogenesis. Biol Reprod 82(2): 422-32. PMID: [19794154]
Ref: P. S. Tanwar, T. Kaneko-Tarui, L. Zhang, P. Rani, M. M. Taketo and J. Teixeira (2010) Constitutive WNT/beta-catenin signaling in murine Sertoli cells disrupts their differentiation and ability to support spermatogenesis. Biol Reprod 82(2): 422-32. PMID: [19794154]
Function
Key downstream component of the canonical Wnt signalingpathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2,APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminalSer and Thr residues and ubiquitination of CTNNB1 via BTRC and itssubsequent degradation by the proteasome. In the presence of Wntligand, CTNNB1 is not ubiquitinated and accumulates in thenucleus, where it acts as a coactivator for transcription factorsof the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. Acts as a negativeregulator of centrosome cohesion. Involved in theCDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization.Blocks anoikis of malignant kidney and intestinal epithelial cellsand promotes their anchorage-independent growth by down-regulatingDAPK2 (By similarity). 
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Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus.Cell junction, adherens junction (By similarity). Cell junction(By similarity). Cell membrane (By similarity). Cytoplasm,cytoskeleton, centrosome (By similarity). Cytoplasm, cytoskeleton,spindle pole (By similarity). Note=Cytoplasmic when it isunstabilized (high level of phosphorylation) or bound to CDH1.Translocates to the nucleus when it is stabilized (low level ofphosphorylation). Interaction with GLIS2 promotes nucleartranslocation. Interaction with EMD inhibits nuclear localization.The majority of beta-catenin is localized to the cell membrane. Ininterphase, colocalizes with CROCC between CEP250 puncta at theproximal end of centrioles, and this localization is dependent onCROCC and CEP250. In mitosis, when NEK2 activity increases, itlocalizes to centrosomes at spindle poles independent of CROCC.Co-localizes with CDK5 in the cell-cell contacts and plasmamembrane of undifferentiated and differentiated neuroblastomacells (By similarity). 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0034742 C:APC-Axin-1-beta-catenin complex ISS:UniProtKB.
GO:0045177 C:apical part of cell IDA:MGI.
GO:0034747 C:Axin-APC-beta-catenin-GSK3B complex IDA:MGI.
GO:0070369 C:beta-catenin-TCF7L2 complex ISS:UniProtKB.
GO:0016342 C:catenin complex ISS:UniProtKB.
GO:0005938 C:cell cortex ISS:UniProtKB.
GO:0005924 C:cell-substrate adherens junction ISS:UniProtKB.
GO:0005813 C:centrosome IDA:BHF-UCL.
GO:0043198 C:dendritic shaft IBA:RefGenome.
GO:0030057 C:desmosome IBA:RefGenome.
GO:0005916 C:fascia adherens IDA:MGI.
GO:0009898 C:internal side of plasma membrane IBA:RefGenome.
GO:0030027 C:lamellipodium IDA:MGI.
GO:0016328 C:lateral plasma membrane IDA:MGI.
GO:0031528 C:microvillus membrane IDA:MGI.
GO:0048471 C:perinuclear region of cytoplasm ISS:UniProtKB.
GO:0032993 C:protein-DNA complex ISS:UniProtKB.
GO:0034750 C:Scrib-APC-beta-catenin complex IDA:BHF-UCL.
GO:0000922 C:spindle pole IEA:UniProtKB-SubCell.
GO:0045202 C:synapse IBA:RefGenome.
GO:0005667 C:transcription factor complex IDA:MGI.
GO:0030018 C:Z disc IDA:MGI.
GO:0005915 C:zonula adherens IBA:RefGenome.
GO:0003682 F:chromatin binding IDA:MGI.
GO:0003690 F:double-stranded DNA binding IDA:MGI.
GO:0003700 F:sequence-specific DNA binding transcription factor activity IDA:MGI.
GO:0005198 F:structural molecule activity IBA:RefGenome.
GO:0003713 F:transcription coactivator activity IDA:UniProtKB.
GO:0044212 F:transcription regulatory region DNA binding IDA:MGI.
GO:0034333 P:adherens junction assembly ISS:UniProtKB.
GO:0009948 P:anterior/posterior axis specification IMP:MGI.
GO:0006915 P:apoptotic process IMP:MGI.
GO:0045453 P:bone resorption IMP:MGI.
GO:0001658 P:branching involved in ureteric bud morphogenesis IMP:MGI.
GO:0044336 P:canonical Wnt receptor signaling pathway involved in negative regulation of apoptotic process IEA:Compara.
GO:0061324 P:canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation IMP:BHF-UCL.
GO:0044334 P:canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition ISS:UniProtKB.
GO:0060038 P:cardiac muscle cell proliferation TAS:DFLAT.
GO:0001708 P:cell fate specification IMP:MGI.
GO:0048469 P:cell maturation IDA:MGI.
GO:0016337 P:cell-cell adhesion IMP:MGI.
GO:0007160 P:cell-matrix adhesion IMP:MGI.
GO:0071363 P:cellular response to growth factor stimulus ISS:UniProtKB.
GO:0071681 P:cellular response to indole-3-methanol ISS:UniProtKB.
GO:0071407 P:cellular response to organic cyclic compound IDA:MGI.
GO:0022009 P:central nervous system vasculogenesis IMP:MGI.
GO:0060982 P:coronary artery morphogenesis TAS:DFLAT.
GO:0007016 P:cytoskeletal anchoring at plasma membrane IBA:RefGenome.
GO:0009950 P:dorsal/ventral axis specification IMP:MGI.
GO:0007398 P:ectoderm development IMP:MGI.
GO:0035117 P:embryonic arm morphogenesis IDA:MGI.
GO:0000578 P:embryonic axis specification IDA:MGI.
GO:0042733 P:embryonic digit morphogenesis IMP:MGI.
GO:0048617 P:embryonic foregut morphogenesis IMP:MGI.
GO:0035050 P:embryonic heart tube development IMP:MGI.
GO:0035116 P:embryonic hindlimb morphogenesis IMP:MGI.
GO:0036023 P:embryonic skeletal limb joint morphogenesis IGI:BHF-UCL.
GO:0001711 P:endodermal cell fate commitment IMP:MGI.
GO:0061154 P:endothelial tube morphogenesis ISS:UniProtKB.
GO:0060983 P:epicardium-derived cardiac vascular smooth muscle cell differentiation TAS:DFLAT.
GO:0060742 P:epithelial cell differentiation involved in prostate gland development IMP:MGI.
GO:0060441 P:epithelial tube branching involved in lung morphogenesis IMP:MGI.
GO:0030900 P:forebrain development IMP:MGI.
GO:0061198 P:fungiform papilla formation IMP:MGI.
GO:0001702 P:gastrulation with mouth forming second IMP:MGI.
GO:0035112 P:genitalia morphogenesis IMP:MGI.
GO:0007403 P:glial cell fate determination IDA:MGI.
GO:0031069 P:hair follicle morphogenesis IMP:MGI.
GO:0060789 P:hair follicle placode formation IMP:MGI.
GO:0030902 P:hindbrain development IBA:RefGenome.
GO:0001701 P:in utero embryonic development IMP:MGI.
GO:0002089 P:lens morphogenesis in camera-type eye IMP:MGI.
GO:0001889 P:liver development IBA:RefGenome.
GO:0060479 P:lung cell differentiation IMP:MGI.
GO:0060492 P:lung induction IMP:MGI.
GO:0060484 P:lung-associated mesenchyme development IMP:MGI.
GO:0030539 P:male genitalia development IMP:MGI.
GO:0060916 P:mesenchymal cell proliferation involved in lung development IMP:MGI.
GO:0003337 P:mesenchymal to epithelial transition involved in metanephros morphogenesis IDA:MGI.
GO:0072132 P:mesenchyme morphogenesis TAS:DFLAT.
GO:0007494 P:midgut development IEA:Compara.
GO:0045445 P:myoblast differentiation IEA:Compara.
GO:0043066 P:negative regulation of apoptotic process IMP:MGI.
GO:0008285 P:negative regulation of cell proliferation ISS:UniProtKB.
GO:0032331 P:negative regulation of chondrocyte differentiation IGI:MGI.
GO:0003136 P:negative regulation of heart induction by canonical Wnt receptor signaling pathway IBA:RefGenome.
GO:0048715 P:negative regulation of oligodendrocyte differentiation IMP:MGI.
GO:0045671 P:negative regulation of osteoclast differentiation IMP:MGI.
GO:0000122 P:negative regulation of transcription from RNA polymerase II promoter IDA:MGI.
GO:0072079 P:nephron tubule formation IMP:MGI.
GO:0001764 P:neuron migration IGI:MGI.
GO:0042475 P:odontogenesis of dentin-containing tooth IMP:MGI.
GO:0048599 P:oocyte development IGI:MGI.
GO:0030316 P:osteoclast differentiation IMP:MGI.
GO:0060066 P:oviduct development IMP:MGI.
GO:0031016 P:pancreas development IMP:MGI.
GO:0001569 P:patterning of blood vessels IMP:MGI.
GO:0045768 P:positive regulation of anti-apoptosis ISS:UniProtKB.
GO:0043065 P:positive regulation of apoptotic process ISS:UniProtKB.
GO:0061047 P:positive regulation of branching involved in lung morphogenesis IMP:MGI.
GO:2000017 P:positive regulation of determination of dorsal identity IDA:MGI.
GO:0045603 P:positive regulation of endothelial cell differentiation IMP:MGI.
GO:0060769 P:positive regulation of epithelial cell proliferation involved in prostate gland development IMP:MGI.
GO:0045743 P:positive regulation of fibroblast growth factor receptor signaling pathway IMP:MGI.
GO:0010909 P:positive regulation of heparan sulfate proteoglycan biosynthetic process ISS:UniProtKB.
GO:0043123 P:positive regulation of I-kappaB kinase/NF-kappaB cascade IMP:MGI.
GO:0043410 P:positive regulation of MAPK cascade IGI:MGI.
GO:0002053 P:positive regulation of mesenchymal cell proliferation IMP:MGI.
GO:0002052 P:positive regulation of neuroblast proliferation IGI:MGI.
GO:0045669 P:positive regulation of osteoblast differentiation IMP:MGI.
GO:0045944 P:positive regulation of transcription from RNA polymerase II promoter ISS:UniProtKB.
GO:0034394 P:protein localization at cell surface ISS:UniProtKB.
GO:0009954 P:proximal/distal pattern formation IMP:MGI.
GO:0090279 P:regulation of calcium ion import ISS:UniProtKB.
GO:0030997 P:regulation of centriole-centriole cohesion ISS:UniProtKB.
GO:0070602 P:regulation of centromeric sister chromatid cohesion IMP:BHF-UCL.
GO:0031641 P:regulation of myelination IMP:MGI.
GO:0072182 P:regulation of nephron tubule epithelial cell differentiation IMP:UniProtKB.
GO:2000008 P:regulation of protein localization at cell surface ISS:UniProtKB.
GO:0003266 P:regulation of secondary heart field cardioblast proliferation IDA:MGI.
GO:0048660 P:regulation of smooth muscle cell proliferation ISS:UniProtKB.
GO:0042129 P:regulation of T cell proliferation IMP:MGI.
GO:0072053 P:renal inner medulla development IMP:MGI.
GO:0072054 P:renal outer medulla development IMP:MGI.
GO:0072033 P:renal vesicle formation IMP:MGI.
GO:0046686 P:response to cadmium ion IEA:Compara.
GO:0034097 P:response to cytokine stimulus IEA:Compara.
GO:0042493 P:response to drug IEA:Compara.
GO:0032355 P:response to estradiol stimulus ISS:UniProtKB.
GO:0014010 P:Schwann cell proliferation IBA:RefGenome.
GO:0043588 P:skin development IMP:MGI.
GO:0050808 P:synapse organization IMP:MGI.
GO:0048489 P:synaptic vesicle transport IMP:MGI.
GO:0033077 P:T cell differentiation in thymus IMP:MGI.
GO:0048538 P:thymus development IMP:MGI.
GO:0060440 P:trachea formation IMP:MGI.
GO:0006351 P:transcription, DNA-dependent IEA:UniProtKB-KW.
GO:0003223 P:ventricular compact myocardium morphogenesis TAS:DFLAT.
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Interpro
IPR011989;    ARM-like.
IPR016024;    ARM-type_fold.
IPR000225;    Armadillo.
IPR013284;    Beta-catenin.
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Pfam
PF00514;    Arm;    4.
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SMART
SM00185;    ARM;    12.
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PROSITE
PS50176;    ARM_REPEAT;    9.
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PRINTS
PR01869;    BCATNINFAMLY.;   
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Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1    781       Catenin beta-1.
                             /FTId=PRO_0000064272.
REPEAT      151    191       ARM 1.
REPEAT      193    234       ARM 2.
REPEAT      235    276       ARM 3.
REPEAT      277    318       ARM 4.
REPEAT      319    360       ARM 5.
REPEAT      361    389       ARM 6.
REPEAT      400    441       ARM 7.
REPEAT      442    484       ARM 8.
REPEAT      489    530       ARM 9.
REPEAT      531    571       ARM 10.
REPEAT      594    636       ARM 11.
REPEAT      637    666       ARM 12.
REGION        1     23       Interaction with VCL.
REGION      772    781       Interaction with SCRIB.
MOD_RES      23     23       Phosphoserine; by GSK3-beta (By
                             similarity).
MOD_RES      29     29       Phosphoserine; by GSK3-beta (By
                             similarity).
MOD_RES      33     33       Phosphoserine; by GSK3-beta and HIPK2.
MOD_RES      37     37       Phosphoserine; by GSK3-beta and HIPK2.
MOD_RES      41     41       Phosphothreonine; by GSK3-beta (By
                             similarity).
MOD_RES      45     45       Phosphoserine (By similarity).
MOD_RES      64     64       Phosphotyrosine; by PTK6 (By similarity).
MOD_RES      86     86       Phosphotyrosine; by CSK (By similarity).
MOD_RES     142    142       Phosphotyrosine; by FYN and PTK6 (By
                             similarity).
MOD_RES     191    191       Phosphoserine (By similarity).
MOD_RES     191    191       Phosphoserine; by CDK5 (By similarity).
MOD_RES     246    246       Phosphoserine; by CDK5 (By similarity).
MOD_RES     551    551       Phosphothreonine.
MOD_RES     552    552       Phosphoserine; by AMPK.
MOD_RES     556    556       Phosphothreonine.
MOD_RES     654    654       Phosphotyrosine.
MOD_RES     675    675       Phosphoserine.
MUTAGEN       8      8       M->P: Loss of interaction with VCL.
MUTAGEN      33     33       S->A: Abolished HIPK2-mediated
                             proteasomal degradation.
MUTAGEN      37     37       S->A: Abolished HIPK2-mediated
                             proteasomal degradation.
MUTAGEN     552    552       S->A: Abolishes AMPK-mediated
                             phosphorylation.
CONFLICT    371    371       T -> I (in Ref. 2; BAB31250).
CONFLICT    478    478       A -> T (in Ref. 2; BAB31250).
CONFLICT    487    487       L -> F (in Ref. 2; BAB31250).
HELIX       121    141
TURN        145    148
TURN        150    152
HELIX       153    160
STRAND      161    164
HELIX       165    180
HELIX       182    189
HELIX       192    204
HELIX       208    221
HELIX       225    233
HELIX       236    242
HELIX       243    245
HELIX       249    265
HELIX       269    275
HELIX       278    284
HELIX       285    287
HELIX       291    305
HELIX       309    317
HELIX       320    330
HELIX       334    347
HELIX       353    359
HELIX       362    367
TURN        368    371
HELIX       375    389
HELIX       399    408
HELIX       414    428
HELIX       432    440
HELIX       443    454
HELIX       458    471
STRAND      473    475
HELIX       478    487
HELIX       491    496
HELIX       504    517
HELIX       521    523
HELIX       524    529
HELIX       532    547
HELIX       566    580
HELIX       584    592
HELIX       596    602
HELIX       608    621
HELIX       625    632
TURN        633    636
HELIX       637    643
HELIX       649    661
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Nucleotide Sequence
Length: 2702 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 781 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
YwhabIntAct 
MUC1BioGRID 
MUC1BioGRID 
MUC1BioGRID 
MUC1BioGRID 
MUC1BioGRID 
MUC1BioGRID 
MUC1BioGRID 
MUC1BioGRID 
MUC1BioGRID 
MUC1BioGRID 
Pcp2BioGRID 
Axin1BioGRID 
Ctnnbip1BioGRID 
MUC1BioGRID 
MUC1BioGRID 
Tax1bp3BioGRID 
ApcBioGRID 
MUC1BioGRID 
Bmpr1aBioGRID 
CDH15BioGRID 
CDH1IntAct 
Cdh1BioGRID 
CDH2IntAct 
Cdh2BioGRID 
CTNNBIP1MINT 
Ctnnbip1BioGRID 
Ctnna1BioGRID 
Csnk1eBioGRID 
APCIntAct 
AXIN1IntAct 
Axin1BioGRID 
Ctnnbip1BioGRID 
Tax1bp3BioGRID 
ApcBioGRID 
BCL9LIntAct 
BCL9IntAct 
Cdh1BioGRID 
Cdh2BioGRID 
Cdh5MINT 
Carm1MINT 
Cby1BioGRID 
Ccnd1BioGRID 
CTNNBIP1IntAct 
Ctnnbip1BioGRID 
CTNNA1MINT 
Ctnnb1BioGRID 
Ctnnb1BioGRID 
Ctnnd1BioGRID 
Tcf7l2BioGRID 
Ctnnd1BioGRID 
Tcf7l2BioGRID 
Axin1BioGRID 
Hnf1aBioGRID 
Tcf7l2BioGRID 
Tcf7l2BioGRID 
Gsk3bBioGRID 
HttMINT 
Tcf4BioGRID 
Csnk1eBioGRID 
Kif3bBioGRID 
Kifap3BioGRID 
Lef1BioGRID 
Mapk8IntAct 
Mapk9IntAct 
Map2k5IntAct 
_IntAct 
Pik3r1IntAct 
Prop1IntAct 
PSEN1BioGRID 
Axin1BioGRID 
Lef1BioGRID 
Kif3bBioGRID 
Cdh2BioGRID 
Axin2BioGRID 
Sox2BioGRID 
Gsk3bBioGRID 
Sox2BioGRID 
Hnf1aBioGRID 
Cdh2BioGRID 
Kif3bBioGRID 
Axin2BioGRID 
Ccnd1BioGRID 
Tcf7l2BioGRID 
ApcBioGRID 
Tcf4BioGRID 
Tcf7l2BioGRID 
Cdh2BioGRID 
Tcf7l2BioGRID 
Tcf7l2BioGRID 
Rac1IntAct 
Arhgap32BioGRID 
Smarca4BioGRID 
Sox2BioGRID 
Tcf7l2BioGRID 
Tax1bp3BioGRID 
Ctnnd1BioGRID 
Tcf7l2BioGRID 
MUC1BioGRID 
MUC1BioGRID 
Ctnnd1BioGRID 
Tcf7l2BioGRID 
Axin1BioGRID 
Tcf7l2BioGRID 
Tcf7l2BioGRID 
FERMINT 
FYNMINT 
HttMINT 
Irs1IntAct 
JunBioGRID 
Kif3bBioGRID 
Kifap3BioGRID 
Lef1IntAct 
Nf2BioGRID 
Map2k5MINT 
MUC1BioGRID 
Grin2bIntAct 
Grin1IntAct 
PIK3R1BioGRID 
Pik3r1MINT 
Pax3BioGRID 
Pcp2BioGRID 
Pecam1IntAct 
Acp1BioGRID 
Prop1BioGRID 
Psen1BioGRID 
PtprfBioGRID 
PtprqBioGRID 
MUC1BioGRID 
MUC1BioGRID 
Axin1BioGRID 
Pax3BioGRID 
Pax3BioGRID 
Kif3bBioGRID 
Cdh2BioGRID 
Axin2BioGRID 
Psen1BioGRID 
PtprfBioGRID 
Wnt4BioGRID 
Acp1BioGRID 
JunBioGRID 
Bmpr1aBioGRID 
Ctnna1BioGRID 
Acp1BioGRID 
Nf2BioGRID 
Cdh2BioGRID 
Kif3bBioGRID 
Axin2BioGRID 
MUC1BioGRID 
MUC1BioGRID 
MUC1BioGRID 
Tcf7l2BioGRID 
_IntAct 
ApcBioGRID 
Pax3BioGRID 
Tcf7l2BioGRID 
Cdh2BioGRID 
Tcf7l2BioGRID 
Tcf7l2BioGRID 
Rac1IntAct 
Arhgap32BioGRID 
SRCMINT 
SNCABioGRID 
TCF7L2IntAct 
Tcf7l2BioGRID 
Tax1bp3BioGRID 
Wnt4BioGRID 
Wnt9aBioGRID 
YES1MINT 
Other Protein-Protein interaction resources
String database  
View Microarray data
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