SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00000896 
UniProt Accession
Theoretical PI
6.53  
Molecular Weight
109940 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Epb41l2 
Gene Synonyms/Alias
Epb4.1l2 
Protein Name
Band 4.1-like protein 2 
Protein Synonyms/Alias
Generally expressed protein 4.1;4.1G 
Organism
Mus musculus (Mouse) 
NCBI Taxonomy ID
10090 
Chromosome Location
chr:10;25079604-25243320;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Protein 4.1G is a member of the protein 4.1 family, which in general serves as adaptors linking transmembrane proteins to the cytoskeleton. Lack of protein 4.1G causes altered expression and localization of the cell adhesion molecule nectin-Like 4 in testis and can cause male infertility. 
The information of related literatures
1. S. Yang, H. Weng, L. Chen, X. Guo, M. Parra, J. Conboy, G. Debnath, A. J. Lambert, L. L. Peters, A. J. Baines, N. Mohandas and X. An (2011) Lack of protein 4.1G causes altered expression and localization of the cell adhesion molecule nectin-like 4 in testis and can cause male infertility. Mol Cell Biol 31(11): 2276-86. 

Abstract
Protein 4.1G is a member of the protein 4.1 family, which in general serves as adaptors linking transmembrane proteins to the cytoskeleton. 4.1G is thought to be widely expressed in many cells and tissues, but its function remains largely unknown. To explore the function of 4.1G in vivo, we generated 4.1G(-/-) mice and bred the mice in two backgrounds PMID: [21482674] 

Back to Top
Figures for illustrating the function of this protein/gene
Ref: S. Yang, H. Weng, L. Chen, X. Guo, M. Parra, J. Conboy, G. Debnath, A. J. Lambert, L. L. Peters, A. J. Baines, N. Mohandas and X. An (2011) Lack of protein 4.1G causes altered expression and localization of the cell adhesion molecule nectin-like 4 in testis and can cause male infertility. Mol Cell Biol 31(11): 2276-86. PMID: [21482674]
Ref: S. Yang, H. Weng, L. Chen, X. Guo, M. Parra, J. Conboy, G. Debnath, A. J. Lambert, L. L. Peters, A. J. Baines, N. Mohandas and X. An (2011) Lack of protein 4.1G causes altered expression and localization of the cell adhesion molecule nectin-like 4 in testis and can cause male infertility. Mol Cell Biol 31(11): 2276-86. PMID: [21482674]
Ref: S. Yang, H. Weng, L. Chen, X. Guo, M. Parra, J. Conboy, G. Debnath, A. J. Lambert, L. L. Peters, A. J. Baines, N. Mohandas and X. An (2011) Lack of protein 4.1G causes altered expression and localization of the cell adhesion molecule nectin-like 4 in testis and can cause male infertility. Mol Cell Biol 31(11): 2276-86. PMID: [21482674]
Ref: S. Yang, H. Weng, L. Chen, X. Guo, M. Parra, J. Conboy, G. Debnath, A. J. Lambert, L. L. Peters, A. J. Baines, N. Mohandas and X. An (2011) Lack of protein 4.1G causes altered expression and localization of the cell adhesion molecule nectin-like 4 in testis and can cause male infertility. Mol Cell Biol 31(11): 2276-86. PMID: [21482674]
Ref: S. Yang, H. Weng, L. Chen, X. Guo, M. Parra, J. Conboy, G. Debnath, A. J. Lambert, L. L. Peters, A. J. Baines, N. Mohandas and X. An (2011) Lack of protein 4.1G causes altered expression and localization of the cell adhesion molecule nectin-like 4 in testis and can cause male infertility. Mol Cell Biol 31(11): 2276-86. PMID: [21482674]
Ref: S. Yang, H. Weng, L. Chen, X. Guo, M. Parra, J. Conboy, G. Debnath, A. J. Lambert, L. L. Peters, A. J. Baines, N. Mohandas and X. An (2011) Lack of protein 4.1G causes altered expression and localization of the cell adhesion molecule nectin-like 4 in testis and can cause male infertility. Mol Cell Biol 31(11): 2276-86. PMID: [21482674]
Function
 
Back to Top
Subcellular Location
Cytoplasm, cytoskeleton (By similarity).Cell membrane (By similarity). 
Tissue Specificity
Widely expressed. 
Gene Ontology
GO IDGO termEvidence
GO:0015629 C:actin cytoskeleton ISS:MGI.
GO:0005737 C:cytoplasm IEA:UniProtKB-KW.
GO:0019898 C:extrinsic to membrane IEA:InterPro.
GO:0005886 C:plasma membrane IEA:UniProtKB-SubCell.
GO:0005198 F:structural molecule activity IEA:InterPro.
GO:0030036 P:actin cytoskeleton organization ISS:MGI.
GO:0030866 P:cortical actin cytoskeleton organization IEA:InterPro.
GO:0008360 P:regulation of cell shape ISS:MGI.
Back to Top
Interpro
IPR008379;    Band_4.1_C.
IPR019749;    Band_41_domain.
IPR019750;    Band_41_fam.
IPR021187;    Band_41_protein.
IPR000798;    Ez/rad/moesin.
IPR014847;    FERM-adjacent.
IPR014352;    FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748;    FERM_central.
IPR019747;    FERM_CS.
IPR000299;    FERM_domain.
IPR018979;    FERM_N.
IPR018980;    FERM_PH-like_C.
IPR011993;    PH_like_dom.
IPR007477;    SAB.
Back to Top
Pfam
PF05902;    4_1_CTD;    1.
PF08736;    FA;    1.
PF09380;    FERM_C;    1.
PF00373;    FERM_M;    1.
PF09379;    FERM_N;    1.
PF04382;    SAB;    1.
Back to Top
SMART
SM00295;    B41;    1.
Back to Top
PROSITE
PS00660;    FERM_1;    1.
PS00661;    FERM_2;    1.
PS50057;    FERM_3;    1.
Back to Top
PRINTS
PR00935;    BAND41.;   
PR00661;    ERMFAMILY.;   
Back to Top
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
INIT_MET      1      1       Removed (By similarity).
CHAIN         2    988       Band 4.1-like protein 2.
                             /FTId=PRO_0000219398.
DOMAIN      211    492       FERM.
REGION      495    651       Hydrophilic.
REGION      652    837       Spectrin--actin-binding.
REGION      838    988       C-terminal (CTD).
MOD_RES       2      2       N-acetylthreonine (By similarity).
MOD_RES      38     38       Phosphoserine.
MOD_RES      46     46       Phosphoserine (By similarity).
MOD_RES      56     56       Phosphoserine (By similarity).
MOD_RES      86     86       Phosphoserine.
MOD_RES      87     87       Phosphotyrosine (By similarity).
MOD_RES     379    379       Phosphoserine (By similarity).
MOD_RES     492    492       Phosphoserine (By similarity).
MOD_RES     543    543       Phosphoserine (By similarity).
MOD_RES     582    582       Phosphoserine.
MOD_RES     606    606       Phosphotyrosine.
MOD_RES     610    610       Phosphoserine.
MOD_RES     630    630       Phosphoserine.
MOD_RES     698    698       Phosphoserine.
MOD_RES     745    745       Phosphothreonine.
CONFLICT    660    660       F -> L (in Ref. 1; AAC40083).
CONFLICT    680    680       E -> G (in Ref. 1; AAC40083).
Back to Top
Nucleotide Sequence
Length: 2964 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 988 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
CALM1IntAct 
Plcg2IntAct 
Rac1IntAct 
SNCABioGRID 
Other Protein-Protein interaction resources
String database  
View Microarray data
Comments