Igf1 gene, encoding insulin-like growth factor 1, stimulates glucose transport inrat bone-derived osteoblastic (PyMS) cells and is effective atmuch lower concentrations than insulin, not only regardingglycogen and DNA synthesis but also with regard to enhancingglucose uptake. It is may invovled in spermatogenesis.
The information of related literatures
1. J. Baker, M. P. Hardy, J. Zhou, C. Bondy, F. Lupu, A. R. Bellve and A. Efstratiadis (1996) Effects of an Igf1 gene null mutation on mouse reproduction. Mol Endocrinol 10(7): 903-18.
Abstract Both sexes of adult mice homozygous for a targeted mutation of the Igf1 gene, encoding insulin-like growth factor 1, are infertile dwarfs (approximately 30% of normal size). The testes are reduced in size less than expected from the degree of dwarfism but sustain spermatogenesis only at 18% of the normal level. The epididymides are overall nearly allometric to the reduced body weight, but the distal regions of the duct, vas deferens, seminal vesicles, and prostate are vestigial. Despite the mutational impact on the epididymis, capacitated sperm are able to fertilize wild type eggs in vitro. It is hypothesized that the infertility of male mutants is caused by failure of androgenization resulting in absence of mating behavior, due to drastically reduced levels of serum testosterone (18% of normal). This hormonal deficiency was correlated with an ultrastructural analysis of mutant Leydig cells revealing a significant developmental delay, while assays in organ culture showed that the basal and LH-stimulated production of testosterone by testicular parenchyma is reduced in comparison with wild type controls. The female mutants fail to ovulate even after administration of gonadotropins, which is apparently the primary cause of their infertility, and possess an infantile uterus that exhibits a dramatic hypoplasia especially in the myometrium. The phenotypic manifestations of the mutation were correlated with the localization of transcripts for insulin-like growth factor I and its cognate receptor in wild type reproductive tissues by in situ hybridization. PMID: [8813730]
Figures for illustrating the function of this protein/gene
Function
The insulin-like growth factors, isolated from plasma,are structurally and functionally related to insulin but have amuch higher growth-promoting activity. May be a physiologicalregulator of [1-14C]-2-deoxy-D-glucose (2DG) transport andglycogen synthesis in osteoblasts. Stimulates glucose transport inrat bone-derived osteoblastic (PyMS) cells and is effective atmuch lower concentrations than insulin, not only regardingglycogen and DNA synthesis but also with regard to enhancingglucose uptake (By similarity).
SIGNAL 1 ? Potential. PROPEP ? 48 By similarity. /FTId=PRO_0000015666. CHAIN 49 118 Insulin-like growth factor I. /FTId=PRO_0000015667. PROPEP 119 153 E peptide. /FTId=PRO_0000015668. REGION 49 77 B. REGION 78 89 C. REGION 90 110 A. REGION 111 118 D. DISULFID 54 96 By similarity. DISULFID 66 109 By similarity. DISULFID 95 100 By similarity. VAR_SEQ 135 153 EVHLKNTSRGSAGNKTYRM -> SPSLSTNKKTKLQRRRKG STFEE (in isoform IGF-IB). /FTId=VSP_012165. Back to Top