SG ID

SG00000934 

UniProt Accession

PLD2_MOUSE;P97813;  

Theoretical PI

6.96  

Molecular Weight

106168 Da  

Genbank Nucleotide ID

U87557; AF052294; AF052291; AF052293; AF052292;  

Genbank Protein ID

AAC53173.1; AAC24519.1; AAC24519.1; AAC24519.1; AAC24519.1; 

Gene Name

Pld2 

Gene Synonyms/Alias

 

Protein Name

Phospholipase D2 

Protein Synonyms/Alias

PLD 2mPLD2EC=3.1.4.4 Choline phosphatase 2; PLD1C; Phosphatidylcholine-hydrolyzing phospholipase D2; 

Mus musculus (Mouse) 

10090 

May have a role in signal-induced cytoskeletalregulation and/or endocytosis. PLD2 is involved in the spermatogenesis of the mouse testis. 

The information of related literatures

1. S. Kim, H. Kim, Y. Lee, J. W. Hyun, Y. H. Lee, M. K. Shin, S. Min do and T. Shin (2007) The expression and cellular localization of phospholipase D isozymes in the developing mouse testis. J Vet Sci 8(3): 209-12. 

Abstract
To examine the involvement of phospholipase D (PLD) isozymes in postnatal testis development, the expression of PLD1 and PLD2 was examined in the mouse testis at postnatal weeks 1, 2, 4, and 8 using Western blot analysis and immunohistochemistry. The expression of both PLD1 and PLD2 increased gradually with development from postnatal week 1 to 8. Immunohistochemically, PLD immunoreactivity was detected in some germ cells in the testis and interstitial Leydig cells at postnatal week 1. PLD was mainly detected in the spermatocytes and residual bodies of spermatids in the testis after 8 weeks after birth. The intense immunostaining of PLD in Leydig cells remained unchanged by postnatal week 8. These findings suggest that PLD isozymes are involved in the spermatogenesis of the mouse testis. PMID: [17679764] 

Figures for illustrating the function of this protein/gene

Function

May have a role in signal-induced cytoskeletalregulation and/or endocytosis. 

Subcellular Location

Membrane; Peripheral membrane protein. 

Tissue Specificity

Ubiquitous. Highest levels in brain and lung. 

Gene Ontology

GO ID	GO term	Evidence
GO:0031526	C:brush border membrane	IDA:MGI.
GO:0005901	C:caveola	IEA:Compara.
GO:0005794	C:Golgi apparatus	IEA:Compara.
GO:0030027	C:lamellipodium	IEA:Compara.
GO:0005634	C:nucleus	IEA:Compara.
GO:0042383	C:sarcolemma	IEA:Compara.
GO:0070290	F:NAPE-specific phospholipase D activity	IEA:EC.
GO:0035091	F:phosphatidylinositol binding	IEA:InterPro.
GO:0004630	F:phospholipase D activity	IEA:EC.
GO:0007154	P:cell communication	IEA:InterPro.
GO:0002031	P:G-protein coupled receptor internalization	IDA:MGI.
GO:0031175	P:neuron projection development	IEA:Compara.
GO:0009395	P:phospholipid catabolic process	IEA:Compara.
GO:0045785	P:positive regulation of cell adhesion	IEA:Compara.
GO:0030335	P:positive regulation of cell migration	IEA:Compara.
GO:0043306	P:positive regulation of mast cell degranulation	IEA:Compara.
GO:0014068	P:positive regulation of phosphatidylinositol 3-kinase cascade	IEA:Compara.
GO:0048260	P:positive regulation of receptor-mediated endocytosis	IEA:Compara.
GO:0042542	P:response to hydrogen peroxide	IEA:Compara.
GO:0001666	P:response to hypoxia	IEA:Compara.
GO:0014070	P:response to organic cyclic compound	IEA:Compara.
GO:0043434	P:response to peptide hormone stimulus	IEA:Compara.

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Interpro

IPR011993;    PH_like_dom.
IPR001683;    Phox.
IPR025202;    PLD-like_dom.
IPR001849;    Pleckstrin_homology.
IPR001736;    PLipase_D/transphosphatidylase.
IPR016555;    PLipase_D_euk.
IPR015679;    PLipase_D_fam.
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Pfam

PF00614;    PLDc;    1.
PF13091;    PLDc_2;    1.
PF00787;    PX;    1.
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SMART

SM00233;    PH;    1.
SM00155;    PLDc;    2.
SM00312;    PX;    1.
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PROSITE

PS50003;    PH_DOMAIN;    FALSE_NEG.
PS50035;    PLD;    2.
PS50195;    PX;    1.
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PRINTS

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: 3494 bp   Go to nucleotide: FASTA

Protein Sequence

Length: 933 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

Ref Databases

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

Ref Databases

View Microarray data

Click to view expression 

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