SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00001102 
UniProt Accession
Theoretical PI
6.5  
Molecular Weight
24384 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Il6 
Gene Synonyms/Alias
Il-6 
Protein Name
Interleukin-6 
Protein Synonyms/Alias
IL-6 B-cell hybridoma growth factor; Interleukin HP-1;Flags: Precursor 
Organism
Mus musculus (Mouse) 
NCBI Taxonomy ID
10090 
Chromosome Location
chr:5;30339701-30346508;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. H. Potashnik, M. A. Elhija, E. Lunenfeld, G. Potashnik, S. Schlatt, E. Nieschlag and M. Huleihel (2005) Interleukin-6 expression during normal maturation of the mouse testis. Eur Cytokine Netw 16(2): 161-5. 

Abstract
In this study, we examined the cellular origin and the expression levels of interleukin-6 (IL-6) during normal maturation of mouse testis. The levels of IL-6 (protein and mRNA) were higher in testicular homogenates of sexually immature than mature mice. Immunohistochemical staining of testicular tissues of sexually immature and adult mice show that testicular germ cells, at different stages of differentiation, Leydig cells/interstitial cells and peritubular cells express IL-6. Our results demonstrate, for the first time, overexpression of IL-6 in testicular tissues of immature mice, as compared to mature mice, as well as the expression of IL-6 in germ cells of testicular tissues of adult and sexually immature mice. Thus, our results may indicate the involvement of the endocrine system (gonadotropins and testosterone) in the regulation of IL-6, which is involved in the regulation of testicular development, functions and spermatogenesis. PMID: [15941688] 

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Figures for illustrating the function of this protein/gene
Function
Cytokine with a wide variety of biological functions. Itis a potent inducer of the acute phase response. Plays anessential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocytedifferentiation. It induces myeloma and plasmacytoma growth andinduces nerve cells differentiation Acts on B-cells, T-cells,hepatocytes, hematopoietic progenitor cells and cells of the CNS.Also acts as a myokine. It is discharged into the bloodstreamafter muscle contraction and acts to increase the breakdown offats and to improve insulin resistance (By similarity). 
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Subcellular Location
Secreted. 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0009897 C:external side of plasma membrane IDA:MGI.
GO:0005615 C:extracellular space IDA:MGI.
GO:0006953 P:acute-phase response IEA:UniProtKB-KW.
GO:0007568 P:aging IEA:Compara.
GO:0046849 P:bone remodeling IEA:Compara.
GO:0060445 P:branching involved in salivary gland morphogenesis IDA:MGI.
GO:0016049 P:cell growth IEA:Compara.
GO:0045454 P:cell redox homeostasis IEA:Compara.
GO:0042832 P:defense response to protozoan IMP:MGI.
GO:0031018 P:endocrine pancreas development IMP:BHF-UCL.
GO:0060664 P:epithelial cell proliferation involved in salivary gland morphogenesis IDA:MGI.
GO:0070091 P:glucagon secretion IMP:BHF-UCL.
GO:0006955 P:immune response IEA:InterPro.
GO:0070102 P:interleukin-6-mediated signaling pathway IDA:MGI.
GO:0046716 P:muscle cell homeostasis IGI:MGI.
GO:0008285 P:negative regulation of cell proliferation IEA:Compara.
GO:0045079 P:negative regulation of chemokine biosynthetic process IDA:MGI.
GO:0043154 P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA:Compara.
GO:0050710 P:negative regulation of cytokine secretion IEA:Compara.
GO:0045721 P:negative regulation of gluconeogenesis IEA:Compara.
GO:0046888 P:negative regulation of hormone secretion IDA:MGI.
GO:0048635 P:negative regulation of muscle organ development IEA:Compara.
GO:0006469 P:negative regulation of protein kinase activity IEA:Compara.
GO:0043526 P:neuroprotection IEA:Compara.
GO:0001781 P:neutrophil apoptotic process IDA:MGI.
GO:0045740 P:positive regulation of DNA replication IEA:Compara.
GO:0050679 P:positive regulation of epithelial cell proliferation IDA:MGI.
GO:0070374 P:positive regulation of ERK1 and ERK2 cascade IEA:Compara.
GO:0045666 P:positive regulation of neuron differentiation IEA:Compara.
GO:0045429 P:positive regulation of nitric oxide biosynthetic process IEA:Compara.
GO:0033160 P:positive regulation of protein import into nucleus, translocation IEA:Compara.
GO:0051897 P:positive regulation of protein kinase B signaling cascade IEA:Compara.
GO:0045630 P:positive regulation of T-helper 2 cell differentiation IDA:MGI.
GO:0045944 P:positive regulation of transcription from RNA polymerase II promoter IGI:MGI.
GO:0051971 P:positive regulation of transmission of nerve impulse IEA:Compara.
GO:0042517 P:positive regulation of tyrosine phosphorylation of Stat3 protein IEA:Compara.
GO:0042981 P:regulation of apoptotic process IMP:MGI.
GO:0008360 P:regulation of cell shape IEA:Compara.
GO:0045188 P:regulation of circadian sleep/wake cycle, non-REM sleep IEA:Compara.
GO:0043200 P:response to amino acid stimulus IEA:Compara.
GO:0046677 P:response to antibiotic IEA:Compara.
GO:0031000 P:response to caffeine IEA:Compara.
GO:0051592 P:response to calcium ion IEA:Compara.
GO:0009409 P:response to cold IEA:Compara.
GO:0042493 P:response to drug IEA:Compara.
GO:0051602 P:response to electrical stimulus IEA:Compara.
GO:0009408 P:response to heat IEA:Compara.
GO:0032868 P:response to insulin stimulus IEA:Compara.
GO:0032496 P:response to lipopolysaccharide IEA:Compara.
GO:0009612 P:response to mechanical stimulus IEA:Compara.
GO:0031667 P:response to nutrient levels IEA:Compara.
GO:0009611 P:response to wounding IDA:MGI.
GO:0042110 P:T cell activation IGI:MGI.
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Interpro
IPR009079;    4_helix_cytokine-like_core.
IPR012351;    4_helix_cytokine_core.
IPR003573;    IL6_MGF_GCSF.
IPR003574;    Interleukin_6.
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Pfam
PF00489;    IL6;    1.
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SMART
SM00126;    IL6;    1.
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PROSITE
PS00254;    INTERLEUKIN_6;    1.
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PRINTS
PR00433;    IL6GCSFMGF.;   
PR00434;    INTERLEUKIN6.;   
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Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
SIGNAL        1     24
CHAIN        25    211       Interleukin-6.
                             /FTId=PRO_0000015588.
DISULFID     70     76
DISULFID     99    109
HELIX        48     68
TURN         69     72
HELIX        74     77
TURN         81     83
HELIX        84     86
STRAND      101    103
HELIX       114    129
HELIX       133    160
HELIX       170    176
HELIX       186    209
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Nucleotide Sequence
Length: 1089 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 211 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
ApcBioGRID 
CdiptString 
Il6stIntAct 
CdiptString 
Pcbp1BioGRID 
ApcBioGRID 
Other Protein-Protein interaction resources
String database  
View Microarray data
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