SG ID

SG00001376 

UniProt Accession

G3UXI4_MOUSE;G3UXI4;  

Theoretical PI

FRAGMENT  

Molecular Weight

25538 Da  

Genbank Nucleotide ID

AC121577; AC157521; AC166820;  

Genbank Protein ID

 

Gene Name

Rgs22 

Gene Synonyms/Alias

 

Protein Name

 

Protein Synonyms/Alias

SubName: Protein Rgs22Flags: Fragment 

Mus musculus (Mouse) 

10090 

Temporarily unavailable 

The information of related literatures

1. Y. Hu, J. Xing, L. Chen, X. Guo, Y. Du, C. Zhao, Y. Zhu, M. Lin, Z. Zhou and J. Sha (2008) RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits. Biol Reprod 79(6): 1021-9. 

Abstract
The heterotrimeric G-protein pathway controls numerous cellular processes, including proliferation, differentiation, migration, membrane trafficking, and embryonic development. Regulator of G-protein signaling (RGS) proteins are known to function at the G-protein level. Here, the functional role of a novel RGS protein, regulator of G-protein signaling 22 (RGS22), in the testis was investigated at the mRNA and protein levels. Our results demonstrate that RGS22 is a testis-specific gene. However, significantly decreased expression of RGS22 was found in the testes of patients with azoospermia. RGS22 was translated or posttranslationally modified into multiple proteins of different molecular sizes in prokaryocytes as well as in the testes. Its protein (NP_056483) was localized in spermatogenic cells and Leydig cells and could interact with guanine nucleotide binding protein, alpha 12, 13, and 11 (GNA12, GNA13, and GNA11). Fragmental GFP-fusion protein tracking revealed that the N-terminal of RGS22 was localized in the nucleus. RGS22 and GNA13 were localized in the nucleus from the elongated spermatid stage onward. Indirect immunofluorescence studies revealed defective expression of GNA13 in macrocephalic and global nucleus spermatozoa. These findings suggest that their functions in this subcellular compartment are likely related to the postmeiotic developmental phase, spermiogenesis. RGS22 may also play a role in GNA13 translocation from the cytoplasm to the nucleus during spermiogenesis. PMID: [18703424] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0005737	C:cytoplasm	IBA:RefGenome.
GO:0005886	C:plasma membrane	IBA:RefGenome.
GO:0005096	F:GTPase activator activity	IBA:RefGenome.
GO:0038032	P:termination of G-protein coupled receptor signaling pathway	IEA:InterPro.

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Interpro

IPR000342;    Regulat_G_prot_signal.
IPR016137;    Regulat_G_prot_signal_superfam.
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Pfam

PF00615;    RGS;    1.
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SMART

SM00315;    RGS;    1.
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PROSITE

PS50132;    RGS;    1.
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PRINTS

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: 200103 bp   Go to nucleotide: FASTA

Protein Sequence

Length: 219 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

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Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

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View Microarray data

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