SG ID

SG00001380 

UniProt Accession

CDN1C_MOUSE;P49919;G3UW61;  

Theoretical PI

4.23  

Molecular Weight

37372 Da  

Genbank Nucleotide ID

U20553; AC023248; CH466531; U22399;  

Genbank Protein ID

AAC52186.1; EDL18208.1; AAA85096.1; 

Gene Name

Cdkn1c 

Gene Synonyms/Alias

Kip2 

Protein Name

Cyclin-dependent kinase inhibitor 1C 

Protein Synonyms/Alias

Cyclin-dependent kinase inhibitor p57; p57Kip2; 

Mus musculus (Mouse) 

10090 

Temporarily unavailable 

The information of related literatures

1. S. T. Kim and M. C. Gye (2004) Expression of p57 in mouse and human testes. Dev Growth Differ 46(6): 495-502. 

Abstract
The expression of cyclin-dependent kinases inhibitors, p57kip2, was investigated during the postnatal development of mouse testis, and in adult human testis. Expression of p57kip2 mRNA was higher in immature than pubertal or adult mouse testes. In postnatal day 7 (PND7) testes, moderate p57kip2 immunoreactivity was found in spermatogonia, but signal was heterogeneous among the spermatogonia. In PND14 testes onward, strong immunoreactivity of p57kip2 was found in the nuclei of early spermatocytes but not in the late pachytene stage onward. In PND28 and PND50 testes, p57kip2 immunoreactivity was varying among the seminiferous tubules. There was no visible signal in late pachytene stage onward. In Leydig cells, heterogeneous immunoreactivity of p57kip2 was found in immature testis and the signal intensity was higher in adult testis than immature ones. In Sertoli cells, weak or negligible immunoreactivity of p57kip2 was found. In human seminiferous tubule, strong immunoreactivity of p57kip2 was found in the nucleus of early spermatocytes, but not in the late pachytene spermatocytes onward and Sertoli cells. These results suggest the possible role of p57kip2 in the regulation of early spermatogonial proliferation, meiotic progression of early spermatocytes and differentiation of Leydig cells in testis. PMID: [15610139] 

Figures for illustrating the function of this protein/gene

Function

Potent tight-binding inhibitor of several G1 cyclin/CDKcomplexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and,to lesser extent, of the mitotic cyclin B-CDC2. Negative regulatorof cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. 

Subcellular Location

Nucleus. 

Tissue Specificity

Expressed in the heart, brain, lung, skeletalmuscle, kidney, pancreas and testis. High levels are seen in theplacenta while low levels are seen in the liver. 

Gene Ontology

GO ID	GO term	Evidence
GO:0005634	C:nucleus	IDA:MGI.
GO:0004861	F:cyclin-dependent protein kinase inhibitor activity	IEA:InterPro.
GO:0007050	P:cell cycle arrest	IEA:InterPro.
GO:0006469	P:negative regulation of protein kinase activity	IEA:GOC.
GO:0000122	P:negative regulation of transcription from RNA polymerase II promoter	IGI:MGI.
GO:0042551	P:neuron maturation	IMP:MGI.
GO:0001890	P:placenta development	IMP:MGI.

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Interpro

IPR003175;    CDI.
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Pfam

PF02234;    CDI;    1.
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SMART

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PROSITE

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PRINTS

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: 1355 bp   Go to nucleotide: FASTA

Protein Sequence

Length: 348 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

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Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

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View Microarray data

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