Tag Content
SG ID
SG00001587 
UniProt Accession
Theoretical PI
8.19  
Molecular Weight
172123 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Sycp2 
Gene Synonyms/Alias
Scp2 
Protein Name
Synaptonemal complex protein 2 
Protein Synonyms/Alias
SCP-2 Synaptonemal complex lateral element protein; 
Organism
Mus musculus (Mouse) 
NCBI Taxonomy ID
10090 
Chromosome Location
chr:2;178079998-178142390;-1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. F. Yang, R. De La Fuente, N. A. Leu, C. Baumann, K. J. McLaughlin and P. J. Wang (2006) Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis. J Cell Biol 173(4): 497-507. 

Abstract
During meiosis, the arrangement of homologous chromosomes is tightly regulated by the synaptonemal complex (SC). Each SC consists of two axial/lateral elements (AEs/LEs), and numerous transverse filaments. SC protein 2 (SYCP2) and SYCP3 are integral components of AEs/LEs in mammals. We find that SYCP2 forms heterodimers with SYCP3 both in vitro and in vivo. An evolutionarily conserved coiled coil domain in SYCP2 is required for binding to SYCP3. We generated a mutant Sycp2 allele in mice that lacks the coiled coil domain. The fertility of homozygous Sycp2 mutant mice is sexually dimorphic; males are sterile because of a block in meiosis, whereas females are subfertile with sharply reduced litter size. Sycp2 mutant spermatocytes exhibit failure in the formation of AEs and chromosomal synapsis. Strikingly, the mutant SYCP2 protein localizes to axial chromosomal cores in both spermatocytes and fetal oocytes, but SYCP3 does not, demonstrating that SYCP2 is a primary determinant of AEs/LEs and, thus, is required for the incorporation of SYCP3 into SCs. PMID: [16717126] 

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Figures for illustrating the function of this protein/gene
Ref: F. Yang, R. De La Fuente, N. A. Leu, C. Baumann, K. J. McLaughlin and P. J. Wang (2006) Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis. J Cell Biol 173(4): 497-507. PMID: [16717126]
Ref: F. Yang, R. De La Fuente, N. A. Leu, C. Baumann, K. J. McLaughlin and P. J. Wang (2006) Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis. J Cell Biol 173(4): 497-507. PMID: [16717126]
Ref: F. Yang, R. De La Fuente, N. A. Leu, C. Baumann, K. J. McLaughlin and P. J. Wang (2006) Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis. J Cell Biol 173(4): 497-507. PMID: [16717126]
Ref: F. Yang, R. De La Fuente, N. A. Leu, C. Baumann, K. J. McLaughlin and P. J. Wang (2006) Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis. J Cell Biol 173(4): 497-507. PMID: [16717126]
Ref: F. Yang, R. De La Fuente, N. A. Leu, C. Baumann, K. J. McLaughlin and P. J. Wang (2006) Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis. J Cell Biol 173(4): 497-507. PMID: [16717126]
Ref: F. Yang, R. De La Fuente, N. A. Leu, C. Baumann, K. J. McLaughlin and P. J. Wang (2006) Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis. J Cell Biol 173(4): 497-507. PMID: [16717126]
Function
Major component of the axial/lateral elements ofsynaptonemal complexes (SCS) during meiotic prophase. May beinvolved in the organization of chromatin by temporarily bindingto DNA scaffold attachment regions. Requires SYCP3, but not SYCP1,in order to be incorporated into the axial/lateral elements. 
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Subcellular Location
Nucleus (By similarity). Note=Inaxial/lateral elements of the tripartite segments of synaptonemalcomplexes (By similarity). 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0000800 C:lateral element IDA:MGI.
GO:0005654 C:nucleoplasm TAS:Reactome.
GO:0003677 F:DNA binding IEA:UniProtKB-KW.
GO:0006915 P:apoptotic process IMP:MGI.
GO:0051301 P:cell division IEA:UniProtKB-KW.
GO:0007143 P:female meiosis IMP:MGI.
GO:0009566 P:fertilization IMP:MGI.
GO:0048808 P:male genitalia morphogenesis IMP:MGI.
GO:0007140 P:male meiosis IMP:MGI.
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Interpro
IPR024832;    SYCP2.
IPR024835;    SYCP2/SYCP2-like.
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Pfam
SMART
PROSITE
PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
CHAIN         1   1500       Synaptonemal complex protein 2.
                             /FTId=PRO_0000072367.
COILED     1388   1429       Potential.
COMPBIAS   1080   1090       Poly-Ser.
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Nucleotide Sequence
Length: bp   Go to nucleotide: FASTA
Protein Sequence
Length: 1500 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data
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