SG ID

SG00001765 

UniProt Accession

CXAR_RAT;Q9R066;Q5M817;Q9R067;  

Theoretical PI

7.66  

Molecular Weight

39949 Da  

Genbank Nucleotide ID

AABR03078554; AABR03079390; AF109643; AF109644; BC088313;  

Genbank Protein ID

AAF01254.1; AAF01255.1; AAH88313.1; 

Gene Name

Cxadr 

Gene Synonyms/Alias

Car 

Protein Name

Coxsackievirus and adenovirus receptor homolog 

Protein Synonyms/Alias

CARrCARFlags: Precursor 

Rattus norvegicus (Rat) 

10116 

Temporarily unavailable 

The information of related literatures

1. M. Mirza, C. Petersen, K. Nordqvist and K. Sollerbrant (2007) Coxsackievirus and adenovirus receptor is up-regulated in migratory germ cells during passage of the blood-testis barrier. Endocrinology 148(11): 5459-69. 

Abstract
The coxsackievirus and adenovirus receptor (CAR) is a cell adhesion molecule expressed in epithelial tight junctions and other cell-cell contacts. Using indirect immunofluorescence, quantitative RT-PCR, and Western blots, the expression and distribution of CAR in developing and adult testis are examined. CAR is highly expressed in both Sertoli and germ cells during perinatal and postnatal development, followed by a rapid down-regulation of both mRNA and protein levels. Interestingly, we find that CAR is a previously unknown downstream target for FSH because CAR mRNA levels were induced in primary cultures of FSH-stimulated Sertoli cells. In contrast to other epithelia, CAR is not a general component of tight junctions in the seminiferous epithelium, and Sertoli cells in the adult testis do not express CAR. Instead, CAR expression is stage dependent and specifically found in migratory germ cells. RT-PCR also demonstrated the presence of junctional adhesion molecule-like (JAML) in the testis. JAML was previously reported by others to form a functional complex with CAR regulating transepithelial migration of leukocytes. The expression of JAML in the testis suggests that a similar functional complex might be present during germ cell migration across the blood-testis barrier. Finally, an intermediate compartment occupied by CAR-positive, migrating germ cells and flanked by two occludin-containing junctions is identified. Together, these results implicate a function for CAR in testis morphogenesis and in migration of germ cells across the blood-testis barrier during spermatogenesis. PMID: [17690169] 

Figures for illustrating the function of this protein/gene

Function

Component of the epithelial apical junction complex thatis essential for the tight junction integrity. Proposed tofunction as a homophilic cell adhesion molecule. Recruits MPDZ tointercellular contact sites. Probably involved in transepithelialmigration of polymorphonuclear leukocytes (PMN) through adhesiveinteractions with AMICA1/JAML located in the plasma membrane ofPMN (By similarity). 

Subcellular Location

Cell membrane; Single-pass type I membraneprotein (By similarity). Cell junction, adherens junction (Bysimilarity). Cell junction, tight junction (By similarity).Basolateral cell membrane; Single-pass type I membrane protein (Bysimilarity). Note=Localized at the intercellular contacts. Inepithelial cells localizes to the apical junction complex composedof tight and adherens junctions. In airway epithelial cellslocalized to basolateral membrane but not to apical surface (Bysimilarity). 

Tissue Specificity

Expressed in heart, brain, spleen, lung,liver, muscle, kidney, testis, spleen and skeletal muscle. 

Gene Ontology

GO ID	GO term	Evidence
GO:0001669	C:acrosomal vesicle	ISS:UniProtKB.
GO:0005912	C:adherens junction	ISS:UniProtKB.
GO:0016323	C:basolateral plasma membrane	IEA:UniProtKB-SubCell.
GO:0044297	C:cell body	ISS:UniProtKB.
GO:0030175	C:filopodium	ISS:UniProtKB.
GO:0030426	C:growth cone	ISS:UniProtKB.
GO:0016021	C:integral to membrane	IEA:UniProtKB-KW.
GO:0014704	C:intercalated disc	IEA:Compara.
GO:0045121	C:membrane raft	ISS:UniProtKB.
GO:0005634	C:nucleus	ISS:UniProtKB.
GO:0005923	C:tight junction	IDA:UniProtKB.
GO:0001618	F:viral receptor activity	TAS:RGD.
GO:0031532	P:actin cytoskeleton reorganization	ISS:UniProtKB.
GO:0048739	P:cardiac muscle fiber development	ISS:UniProtKB.
GO:0045216	P:cell-cell junction organization	ISS:UniProtKB.
GO:0010669	P:epithelial structure maintenance	ISS:UniProtKB.
GO:0008354	P:germ cell migration	ISS:UniProtKB.
GO:0007157	P:heterophilic cell-cell adhesion	ISS:UniProtKB.
GO:0034109	P:homotypic cell-cell adhesion	ISS:UniProtKB.
GO:0007005	P:mitochondrion organization	ISS:UniProtKB.
GO:0060044	P:negative regulation of cardiac muscle cell proliferation	IEA:Compara.
GO:0030593	P:neutrophil chemotaxis	ISS:UniProtKB.

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Interpro

IPR007110;    Ig-like.
IPR013783;    Ig-like_fold.
IPR003599;    Ig_sub.
IPR003598;    Ig_sub2.
IPR013106;    Ig_V-set.
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Pfam

PF07686;    V-set;    1.
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SMART

SM00409;    IG;    1.
SM00408;    IGc2;    1.
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PROSITE

PS50835;    IG_LIKE;    2.
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PRINTS

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 365 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

Ref Databases

Other Protein-Protein interaction resources

String database  

UniProt	Gene Symbol	Ref Databases
CLMP_RAT	Asam	String
CLMP_RAT	Asam	String
ESAM_RAT	Esam	String
IGS11_RAT	Igsf11	String
NPHN_RAT	Nphs1	String
OCLN_RAT	Ocln	String
ESAM_RAT	Esam	String
IGS11_RAT	Igsf11	String
NPHN_RAT	Nphs1	String
OCLN_RAT	Ocln	String

View Microarray data

Temporarily unavailable 

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