SG ID

SG00001768 

UniProt Accession

G3V689_RAT;G3V689;  

Theoretical PI

8.33  

Molecular Weight

104622 Da  

Genbank Nucleotide ID

CH473967;  

Genbank Protein ID

EDM11079.1; 

Gene Name

Cblb 

Gene Synonyms/Alias

ORFNames=rCG_52937 

Protein Name

 

Protein Synonyms/Alias

SubName: Casitas B-lineage lymphoma b, isoform CRA_aSubName: E3 ubiquitin-protein ligase CBL-B 

Rattus norvegicus (Rat) 

10116 

Temporarily unavailable 

The information of related literatures

1. N. El Chami, F. Ikhlef, K. Kaszas, S. Yakoub, E. Tabone, B. Siddeek, S. Cunha, C. Beaudoin, L. Morel, M. Benahmed and D. C. Regnier (2005) Androgen-dependent apoptosis in male germ cells is regulated through the proto-oncoprotein Cbl. J Cell Biol 171(4): 651-61. 

Abstract
The proto-oncoprotein Cbl is known to control several signaling processes. It is highly expressed in the testis, and because spermatogenesis is androgen dependent, we investigated the androgen dependency expression of Cbl through its testicular sub-localization and its expression levels in rats that were exposed to the antiandrogen flutamide or were hypophysectomized. We report the androgen dependency of Cbl as it localizes in pachytene spermatocytes during androgen-dependent stages, is down-regulated upon flutamide exposure, and is up-regulated with testosterone in hypophysectomized rats. Coculture experiments showed the key control exerted by the Sertoli cell on Cbl activity. As flutamide induces germ cell apoptosis, we investigate members of the Bcl-2 family upon flutamide exposure. We show that the proapoptotic Bcl-2 family member Bim mirrored Cbl expression through a posttranscriptional process. We also show that in Cbl knockout mouse testes, the imbalance between the high expression of Bim and Smac/Diablo and anti-apoptotic factors such as cellular inhibitor of apoptosis 2 favors a survival process, which makes these mice unresponsive to androgen withdrawal and could explain their hypofertility. PMID: [16301331] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0005634	C:nucleus	IEA:InterPro.
GO:0005509	F:calcium ion binding	IEA:InterPro.
GO:0004871	F:signal transducer activity	IEA:InterPro.
GO:0004842	F:ubiquitin-protein ligase activity	IEA:InterPro.
GO:0008270	F:zinc ion binding	IEA:InterPro.
GO:0007166	P:cell surface receptor signaling pathway	IEA:InterPro.
GO:0016567	P:protein ubiquitination	IEA:GOC.
GO:0023051	P:regulation of signaling	IEA:InterPro.

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Interpro

IPR024162;    Adaptor_Cbl.
IPR014741;    Adaptor_Cbl_EF_hand-like.
IPR003153;    Adaptor_Cbl_N_hlx.
IPR014742;    Adaptor_Cbl_SH2-like.
IPR024159;    Cbl_PTB.
IPR011992;    EF-hand-like_dom.
IPR000980;    SH2.
IPR015940;    UBA/transl_elong_EF1B_N_euk.
IPR001841;    Znf_RING.
IPR013083;    Znf_RING/FYVE/PHD.
IPR017907;    Znf_RING_CS.
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Pfam

PF02262;    Cbl_N;    1.
PF02761;    Cbl_N2;    1.
PF02762;    Cbl_N3;    1.
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SMART

SM00184;    RING;    1.
SM00252;    SH2;    1.
SM00165;    UBA;    1.
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PROSITE

PS51506;    CBL_PTB;    1.
PS50030;    UBA;    1.
PS00518;    ZF_RING_1;    1.
PS50089;    ZF_RING_2;    1.
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PRINTS

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 938 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

Ref Databases

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

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View Microarray data

Temporarily unavailable 

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