SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00001830 
UniProt Accession
Theoretical PI
4.68  
Molecular Weight
20291 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Ppp3r2 
Gene Synonyms/Alias
Cblp 
Protein Name
Calcineurin subunit B type 2 
Protein Synonyms/Alias
Calcineurin B-like protein;CBLP Protein phosphatase 2B regulatory subunit 2; Protein phosphatase 3 regulatory subunit B beta isoform; 
Organism
Rattus norvegicus (Rat) 
NCBI Taxonomy ID
10116 
Chromosome Location
chr:5;66423374-66424371;-1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. K. Miyamoto, H. Matsui, K. Tomizawa, Y. Kuwata, T. Itano, M. Tokuda and O. Hatase (1994) In situ localization of rat testis-specific calcineurin B subunit isoform beta 1 in the developing rat testis. Biochem Biophys Res Commun 203(2): 1275-83. 

Abstract
In situ localization and developmental changes in expression of testis-specific calcineurin B subunit isoform beta 1 was examined in rat testis. Two different sizes of mRNA signal, 4.0 kb and 0.9 kb, were detected by Northern blot hybridization. Both signals were expressed synchronously with the start of meiosis at 3 weeks after birth, and increased depending on the maturation of spermatogenesis. In situ hybridization using non-radioactive riboprobes showed that the beta 1 mRNA was specifically localized to spermatocytes where meiosis occurs but none or very little was observed in spermatogonia, spermatids, Sertoli or Leydig cells. PMID: [8093044] 

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Figures for illustrating the function of this protein/gene
Function
Regulatory subunit of calcineurin, a calcium-dependent,calmodulin stimulated protein phosphatase. Confers calciumsensitivity. 
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Subcellular Location
 
Tissue Specificity
Testis specific. 
Gene Ontology
GO IDGO termEvidence
GO:0005829 C:cytosol TAS:Reactome.
GO:0005509 F:calcium ion binding IEA:InterPro.
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Interpro
IPR018248;    EF-hand.
IPR011992;    EF-hand-like_dom.
IPR018247;    EF_Hand_1_Ca_BS.
IPR018249;    EF_HAND_2.
IPR002048;    EF_hand_Ca-bd.
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Pfam
PF00036;    efhand;    1.
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SMART
SM00054;    EFh;    4.
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PROSITE
PS00018;    EF_HAND_1;    4.
PS50222;    EF_HAND_2;    4.
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PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
INIT_MET      1      1       Removed (By similarity).
CHAIN         2    176       Calcineurin subunit B type 2.
                             /FTId=PRO_0000073501.
DOMAIN       18     53       EF-hand 1.
DOMAIN       50     85       EF-hand 2.
DOMAIN       87    122       EF-hand 3.
DOMAIN      128    163       EF-hand 4.
CA_BIND      31     42       1.
CA_BIND      63     74       2.
CA_BIND     100    111       3.
CA_BIND     141    152       4.
LIPID         2      2       N-myristoyl glycine (By similarity).
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Nucleotide Sequence
Length: 742 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 176 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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