SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00001840 
UniProt Accession
Theoretical PI
5.9  
Molecular Weight
18866 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Lep 
Gene Synonyms/Alias
Ob 
Protein Name
Leptin 
Protein Synonyms/Alias
Obesity factor;Flags: Precursor 
Organism
Rattus norvegicus (Rat) 
NCBI Taxonomy ID
10116 
Chromosome Location
chr:4;55943837-55945938;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. B. Chen, J. H. Guo, Y. N. Lu, X. L. Ying, K. Hu, Z. Q. Xiang, Y. X. Wang, P. Chen and Y. R. Huang (2009) Leptin and varicocele-related spermatogenesis dysfunction. Int J Androl 32(5): 532-41. 

Abstract
The objective of this study was to explore the relationships between varicocele-related spermatogenesis dysfunction and the expression of leptin and leptin receptors. In rats with experimental varicocele, the function of spermatogenesis, the expression of leptin and leptin receptors in testes were analysed; and in patients with varicocele-related male infertility, serum and seminal plasma levels of leptin, gonadal hormones and semen parameters were evaluated. In the testes of rats, leptin was expressed in seminiferous tubules and intersitium, leptin receptor was predominantly expressed in interstitium. The expression of leptin and its receptor in the testis of rats was not related to the weight of rat, but was inversely related to the weight of testis (r = -0.408, p = 0.009 and r = -0.433, p = 0.005, respectively), the Johnsen scores (r = -0.916, p = 0.000 and r = -0.863, p = 0.000, respectively), the seminiferous tubules diameter (r = -0.853, p = 0.000 and r = -0.870, p = 0.000, respectively) and the thickness of seminiferous epithelium (r = -0.929, p = 0.000 and r = -0.948, p = 0.000, respectively). In varicocele patients (N = 40), the sperm concentration and motility were significantly lower (p = 0.000) than those in the control group (N = 25), and the leptin level in seminal plasma was significantly higher (p = 0.000) than that in the control group. The leptin in serum and seminal plasma was positively related (r = 0.223, p = 0.002). The seminal plasma leptin level was inversely related to sperm concentration (r = -0.632, p = 0.000) and motility (r = -0.635, p = 0.000). There was no significant relation between serum leptin and seminal parameters and between leptin and gonadal hormone values. The dysfunction of spermatogenesis in varicocele-related infertile male is associated with increase in leptin and leptin receptors. Leptin may have local effects on the function of testis and spermatogenesis. PMID: [18484972] 

Back to Top
Figures for illustrating the function of this protein/gene
Function
May function as part of a signaling pathway that acts toregulate the size of the body fat depot. An increase in the levelof Lep may act directly or indirectly on the CNS to inhibit foodintake and/or regulate energy expenditure as part of a homeostaticmechanism to maintain constancy of the adipose mass. 
Back to Top
Subcellular Location
Secreted (Probable). 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0005615 C:extracellular space IDA:HGNC.
GO:0005622 C:intracellular IDA:GOC.
GO:0060612 P:adipose tissue development IEA:Compara.
GO:0008343 P:adult feeding behavior ISS:HGNC.
GO:0008206 P:bile acid metabolic process IEA:Compara.
GO:0035630 P:bone mineralization involved in bone maturation IDA:RGD.
GO:0019933 P:cAMP-mediated signaling TAS:RGD.
GO:0071298 P:cellular response to L-ascorbic acid IEP:RGD.
GO:0071300 P:cellular response to retinoic acid IEP:RGD.
GO:0021954 P:central nervous system neuron development IEA:Compara.
GO:0008203 P:cholesterol metabolic process IEA:Compara.
GO:0007623 P:circadian rhythm IEP:RGD.
GO:0042755 P:eating behavior IEA:Compara.
GO:0006112 P:energy reserve metabolic process IDA:RGD.
GO:0009062 P:fatty acid catabolic process IDA:RGD.
GO:0007565 P:female pregnancy IEP:RGD.
GO:0006006 P:glucose metabolic process IEA:Compara.
GO:0006114 P:glycerol biosynthetic process IDA:RGD.
GO:0042445 P:hormone metabolic process IEA:Compara.
GO:0030073 P:insulin secretion IEA:Compara.
GO:0007259 P:JAK-STAT cascade TAS:RGD.
GO:0033210 P:leptin-mediated signaling pathway IDA:RGD.
GO:0050901 P:leukocyte tethering or rolling IDA:RGD.
GO:0043066 P:negative regulation of apoptotic process IDA:RGD.
GO:0032099 P:negative regulation of appetite ISS:HGNC.
GO:0061037 P:negative regulation of cartilage development IDA:RGD.
GO:0070093 P:negative regulation of glucagon secretion IEA:Compara.
GO:2000486 P:negative regulation of glutamine transport IMP:RGD.
GO:0009892 P:negative regulation of metabolic process IDA:RGD.
GO:0000122 P:negative regulation of transcription from RNA polymerase II promoter IEA:Compara.
GO:0045906 P:negative regulation of vasoconstriction IDA:RGD.
GO:0001542 P:ovulation from ovarian follicle IDA:RGD.
GO:0001890 P:placenta development IEA:Compara.
GO:0008284 P:positive regulation of cell proliferation IDA:RGD.
GO:0001819 P:positive regulation of cytokine production IEP:RGD.
GO:0048639 P:positive regulation of developmental growth IEA:Compara.
GO:0046881 P:positive regulation of follicle-stimulating hormone secretion IEP:RGD.
GO:2000491 P:positive regulation of hepatic stellate cell activation IDA:RGD.
GO:0046628 P:positive regulation of insulin receptor signaling pathway IDA:RGD.
GO:0043270 P:positive regulation of ion transport IDA:RGD.
GO:0033686 P:positive regulation of luteinizing hormone secretion IEP:RGD.
GO:0043410 P:positive regulation of MAPK cascade IDA:RGD.
GO:0045639 P:positive regulation of myeloid cell differentiation IEA:Compara.
GO:2000366 P:positive regulation of STAT protein import into nucleus IEA:Compara.
GO:0042517 P:positive regulation of tyrosine phosphorylation of Stat3 protein IMP:RGD.
GO:0008217 P:regulation of blood pressure IDA:RGD.
GO:0006111 P:regulation of gluconeogenesis IEA:Compara.
GO:0050796 P:regulation of insulin secretion IEA:Compara.
GO:0030300 P:regulation of intestinal cholesterol absorption IEA:Compara.
GO:0060587 P:regulation of lipoprotein lipid oxidation IDA:RGD.
GO:0050810 P:regulation of steroid biosynthetic process IEA:Compara.
GO:0002021 P:response to dietary excess IMP:RGD.
GO:0001666 P:response to hypoxia IEP:RGD.
GO:0032868 P:response to insulin stimulus IEA:Compara.
GO:0033197 P:response to vitamin E IEP:RGD.
GO:0007260 P:tyrosine phosphorylation of STAT protein IEA:Compara.
Back to Top
Interpro
IPR009079;    4_helix_cytokine-like_core.
IPR012351;    4_helix_cytokine_core.
IPR000065;    Leptin.
Back to Top
Pfam
PF02024;    Leptin;    1.
Back to Top
SMART
PROSITE
PRINTS
PR00495;    LEPTIN.;   
Back to Top
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
SIGNAL        1     21       Potential.
CHAIN        22    167       Leptin.
                             /FTId=PRO_0000017690.
DISULFID    117    167       By similarity.
CONFLICT     32     32       K -> T (in Ref. 2).
CONFLICT    163    163       L -> V (in Ref. 4; AAC52514).
Back to Top
Nucleotide Sequence
Length: 698 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 167 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
Comments