1. W. Yan, J. Kero, J. Suominen and J. Toppari (2001) Differential expression and regulation of the retinoblastoma family of proteins during testicular development and spermatogenesis. Oncogene 20(11): 1343-56.
Abstract Normal spermatogenesis is highly dependent on well-balanced germ cell proliferation, differentiation, and apoptosis. However, the molecular mechanisms that govern these processes are largely unknown. Retinoblastoma family proteins (pRb, p107 and p130) are potentially important regulators of cell growth, differentiation and apoptosis. pRb has been shown to be expressed in the rat testis and involved in the regulation of spermatogenesis. In the present study, the expression and localization of the other two pRb family members, p107 and p130, were analysed at both mRNA and protein levels during testicular development and spermatogenesis using Northern, Western blotting, immunohistochemistry, and in situ hybridization. Furthermore, changes of levels and phosphorylation status of pRb family proteins in response to growth suppression and/or apoptosis induction were investigated using a seminiferous tubule culture system and three animal models. Our data suggest that PMID: [11313878]
Figures for illustrating the function of this protein/gene
Ref: W. Yan, J. Kero, J. Suominen and J. Toppari (2001) Differential expression and regulation of the retinoblastoma family of proteins during testicular development and spermatogenesis. Oncogene 20(11): 1343-56. PMID: [11313878]
Ref: W. Yan, J. Kero, J. Suominen and J. Toppari (2001) Differential expression and regulation of the retinoblastoma family of proteins during testicular development and spermatogenesis. Oncogene 20(11): 1343-56. PMID: [11313878]
Ref: W. Yan, J. Kero, J. Suominen and J. Toppari (2001) Differential expression and regulation of the retinoblastoma family of proteins during testicular development and spermatogenesis. Oncogene 20(11): 1343-56. PMID: [11313878]
Ref: W. Yan, J. Kero, J. Suominen and J. Toppari (2001) Differential expression and regulation of the retinoblastoma family of proteins during testicular development and spermatogenesis. Oncogene 20(11): 1343-56. PMID: [11313878]
Ref: W. Yan, J. Kero, J. Suominen and J. Toppari (2001) Differential expression and regulation of the retinoblastoma family of proteins during testicular development and spermatogenesis. Oncogene 20(11): 1343-56. PMID: [11313878]