SG ID

SG00001851 

UniProt Accession

D3ZS28_RAT;D3ZS28;  

Theoretical PI

8.14  

Molecular Weight

119473 Da  

Genbank Nucleotide ID

 

Genbank Protein ID

 

Gene Name

Rbl1 

Gene Synonyms/Alias

 

Protein Name

 

Protein Synonyms/Alias

SubName: Protein Rbl1 

Rattus norvegicus (Rat) 

10116 

Temporarily unavailable 

The information of related literatures

1. W. Yan, J. Kero, J. Suominen and J. Toppari (2001) Differential expression and regulation of the retinoblastoma family of proteins during testicular development and spermatogenesis. Oncogene 20(11): 1343-56. 

Abstract
Normal spermatogenesis is highly dependent on well-balanced germ cell proliferation, differentiation, and apoptosis. However, the molecular mechanisms that govern these processes are largely unknown. Retinoblastoma family proteins (pRb, p107 and p130) are potentially important regulators of cell growth, differentiation and apoptosis. pRb has been shown to be expressed in the rat testis and involved in the regulation of spermatogenesis. In the present study, the expression and localization of the other two pRb family members, p107 and p130, were analysed at both mRNA and protein levels during testicular development and spermatogenesis using Northern, Western blotting, immunohistochemistry, and in situ hybridization. Furthermore, changes of levels and phosphorylation status of pRb family proteins in response to growth suppression and/or apoptosis induction were investigated using a seminiferous tubule culture system and three animal models. Our data suggest that PMID: [11313878] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0005667	C:transcription factor complex	IEA:Compara.
GO:0000122	P:negative regulation of transcription from RNA polymerase II promoter	IEA:Compara.
GO:0051726	P:regulation of cell cycle	IEA:InterPro.

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Interpro

IPR013763;    Cyclin-like.
IPR024599;    DUF3452_retinoblatoma-assoc.
IPR002720;    RB_A.
IPR002719;    RB_B.
IPR015030;    Rb_C.
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Pfam

PF11934;    DUF3452;    1.
PF01858;    RB_A;    1.
PF01857;    RB_B;    1.
PF08934;    Rb_C;    1.
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SMART

SM00385;    CYCLIN;    1.
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PROSITE

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PRINTS

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 1063 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

Ref Databases

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

Ref Databases

View Microarray data

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