SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00001852 
UniProt Accession
Theoretical PI
4.37  
Molecular Weight
30997 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
C1qbp 
Gene Synonyms/Alias
Gc1qbp 
Protein Name
Complement component 1 Q subcomponent-binding protein, mitochondrial 
Protein Synonyms/Alias
GC1q-R protein; Glycoprotein gC1qBP;C1qBPFlags: Precursor 
Organism
Rattus norvegicus (Rat) 
NCBI Taxonomy ID
10116 
Chromosome Location
chr:10;57881795-57886469;-1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. V. Kumar, M. M. Misro and K. Datta (2011) Simultaneous Accumulation of Hyaluronan Binding Protein 1 (HABP1/p32/gC1qR) and Apoptotic Induction of Germ Cells in Cryptorchid Testis. J Androl (): . 

Abstract
In the experimentally cryptorchid rat, spermatogenic arrest is associated with the formation of multinuclear giant cells leading to large scale apoptosis and elimination of germ cells from the seminiferous epithelium. Using this model, the role of HABP1 was examined which expresses stage specifically during spermatogenesis. Cryptorchidism induced complete arrest of spermatogenesis by 2 days and by 3-5 days many large and small multinucleated giant cells populated the affected tubules. Ultra-structure of the giant cells revealed both single and multiple chromatin aggregation, some less compact, distorted and others broken down into tiny fragments. These cells along with other germ cells were stained TUNEL positive demonstrating strong expression of Bax and Heat Shock Protein (hsp) 70. Simultaneously, there was an upregulation of the pro-protein form of HABP1 in these cells and a decrease in the mature form of protein. The above findings indicate a possible role of HABP1 proprotein in apoptosis induction of germ cells in the cryptorchid testes. PMID: [21311052] 

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Figures for illustrating the function of this protein/gene
Function
Binds to the globular "heads" of C1Q thus inhibiting C1activation. 
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Subcellular Location
Mitochondrion matrix (Potential). 
Tissue Specificity
Ubiquitous. 
Gene Ontology
GO IDGO termEvidence
GO:0005737 C:cytoplasm IDA:RGD.
GO:0005615 C:extracellular space IDA:RGD.
GO:0016020 C:membrane IEA:Compara.
GO:0005759 C:mitochondrial matrix IEA:UniProtKB-SubCell.
GO:0005634 C:nucleus IDA:RGD.
GO:0006955 P:immune response TAS:RGD.
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Interpro
IPR003428;    MAM33.
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Pfam
PF02330;    MAM33;    1.
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SMART
PROSITE
PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
TRANSIT       1     71       Mitochondrion (By similarity).
CHAIN        72    279       Complement component 1 Q subcomponent-
                             binding protein, mitochondrial.
                             /FTId=PRO_0000018592.
MOD_RES      89     89       N6-acetyllysine (By similarity).
MOD_RES     185    185       Phosphotyrosine (By similarity).
MOD_RES     198    198       Phosphoserine (By similarity).
CONFLICT     63     64       VP -> GS (in Ref. 1; CAA04531).
CONFLICT     68     70       GCG -> AA (in Ref. 1; CAA04531).
CONFLICT    107    107       W -> G (in Ref. 1; CAA04531).
CONFLICT    193    193       E -> Q (in Ref. 1; CAA04531).
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Nucleotide Sequence
Length: 1124 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 279 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
Slc2a4IntAct 
HnrnpkIntAct 
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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