SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00001855 
UniProt Accession
Theoretical PI
6.8  
Molecular Weight
56000 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Tgfbr1 
Gene Synonyms/Alias
 
Protein Name
TGF-beta receptor type-1 
Protein Synonyms/Alias
TGFR-1EC=2.7.11.30 Serine/threonine-protein kinase receptor R4;SKR4 TGF-beta type I receptor; Transforming growth factor-beta receptor type I;TGF-beta receptor type ITbetaR-IFlags: Precursor 
Organism
Rattus norvegicus (Rat) 
NCBI Taxonomy ID
10116 
Chromosome Location
chr:5;63976868-64034058;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. R. Olaso, C. Pairault and R. Habert (1998) Expression of type I and II receptors for transforming growth factor beta in the adult rat testis. Histochem Cell Biol 110(6): 613-8. 

Abstract
After having established the specificity of the antibodies for the rat testis by western blot analysis, the potential target cells for transforming growth factors (TGFbetas) were identified by immunohistochemical detection of both type I (TbetaRI) and type II (TbetaRII) transducing receptors for TGFbetas in the adult rat testis in situ. Leydig cells showed a strong TbetaRII immunoreactivity whereas the TbetaRI staining was weak. Only TbetaRII was detectable in Sertoli cells. In germ cells, staining for TbetaRI was stronger than for TbetaRII and the expression of both receptors depended on the seminiferous cycle stage. TbetaRI first appeared in pachytene spermatocytes and was absent in elongated spermatids from stage XIV onwards. Labelling for TbetaRII was observed as early as the spermatogonia stage; it increased in pachytene spermatocytes at the onset of TbetaRI and disappeared in elongating spermatids from stage XI onwards. These results show that TGFbetas can affect somatic cells functions and suggest that these factors are involved in the control of meiosis and early spermiogenesis, exerting a direct effect on germ cells. PMID: [9860260] 

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Figures for illustrating the function of this protein/gene
Function
Transmembrane serine/threonine kinase forming with theTGF-beta type II serine/threonine kinase receptor, TGFBR2, thenon-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from thecell surface to the cytoplasm and is thus regulating a plethora ofphysiological and pathological processes including cell cyclearrest in epithelial and hematopoietic cells, control ofmesenchymal cell proliferation and differentiation, wound healing,extracellular matrix production, immunosuppression andcarcinogenesis. The formation of the receptor complex composed of2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to thecytokine dimer results in the phosphorylation and the activationof TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1phosphorylates SMAD2 which dissociates from the receptor andinteracts with SMAD4. The SMAD2-SMAD4 complex is subsequentlytranslocated to the nucleus where it modulates the transcriptionof the TGF-beta-regulated genes. This constitutes the canonicalSMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. Forinstance, TGFBR1 induces TRAF6 autoubiquitination which in turnresults in MAP3K7 ubiquitination and activation to triggerapoptosis. Also regulates epithelial to mesenchymal transitionthrough a SMAD-independent signaling pathway through PARD6Aphosphorylation and activation (By similarity). 
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Subcellular Location
Cell membrane; Single-pass type I membraneprotein (By similarity). Cell junction, tight junction (Bysimilarity). 
Tissue Specificity
Urogenital ridge, testis, ovary, brain andlungs. 
Gene Ontology
GO IDGO termEvidence
GO:0016324 C:apical plasma membrane IDA:RGD.
GO:0016323 C:basolateral plasma membrane IDA:RGD.
GO:0005901 C:caveola IDA:MGI.
GO:0005923 C:tight junction IEA:UniProtKB-SubCell.
GO:0070022 C:transforming growth factor beta receptor homodimeric complex IC:RGD.
GO:0005524 F:ATP binding IMP:RGD.
GO:0046872 F:metal ion binding IEA:UniProtKB-KW.
GO:0005025 F:transforming growth factor beta receptor activity, type I IMP:RGD.
GO:0007568 P:aging IEP:RGD.
GO:0001525 P:angiogenesis IEA:Compara.
GO:0009952 P:anterior/posterior pattern specification IEA:Compara.
GO:0006915 P:apoptotic process IEA:UniProtKB-KW.
GO:0048844 P:artery morphogenesis IEA:Compara.
GO:0001824 P:blastocyst development IEA:Compara.
GO:0071560 P:cellular response to transforming growth factor beta stimulus IEA:Compara.
GO:0030199 P:collagen fibril organization IEA:Compara.
GO:0048565 P:digestive tract development IEP:RGD.
GO:0009790 P:embryo development IEP:RGD.
GO:0007566 P:embryo implantation IEP:RGD.
GO:0048701 P:embryonic cranial skeleton morphogenesis IEA:Compara.
GO:0043542 P:endothelial cell migration IEA:Compara.
GO:0008354 P:germ cell migration IEA:Compara.
GO:0007507 P:heart development IEA:Compara.
GO:0006917 P:induction of apoptosis IEA:Compara.
GO:0001822 P:kidney development IEA:Compara.
GO:0002088 P:lens development in camera-type eye IEA:Compara.
GO:0030324 P:lung development IEP:RGD.
GO:0043066 P:negative regulation of apoptotic process IEA:Compara.
GO:0032331 P:negative regulation of chondrocyte differentiation IEA:Compara.
GO:0045602 P:negative regulation of endothelial cell differentiation IMP:RGD.
GO:0048663 P:neuron fate commitment IEA:Compara.
GO:0031100 P:organ regeneration IEP:RGD.
GO:0060021 P:palate development IEA:Compara.
GO:0060017 P:parathyroid gland development IEA:Compara.
GO:0060037 P:pharyngeal system development IEA:Compara.
GO:0051491 P:positive regulation of filopodium assembly IEA:Compara.
GO:0009791 P:post-embryonic development IEA:Compara.
GO:0046777 P:protein autophosphorylation IMP:RGD.
GO:0010468 P:regulation of gene expression IEA:Compara.
GO:0040008 P:regulation of growth IEA:UniProtKB-KW.
GO:0043393 P:regulation of protein binding IEA:Compara.
GO:0051602 P:response to electrical stimulus IEP:RGD.
GO:0043627 P:response to estrogen stimulus IDA:RGD.
GO:0001666 P:response to hypoxia IEP:RGD.
GO:0014070 P:response to organic cyclic compound IEP:RGD.
GO:0034695 P:response to prostaglandin E stimulus IEP:RGD.
GO:0009636 P:response to toxin IEP:RGD.
GO:0048538 P:thymus development IEA:Compara.
GO:0007179 P:transforming growth factor beta receptor signaling pathway IMP:RGD.
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Interpro
IPR000472;    Activin_rcpt.
IPR011009;    Kinase-like_dom.
IPR000719;    Prot_kinase_cat_dom.
IPR017441;    Protein_kinase_ATP_BS.
IPR008271;    Ser/Thr_kinase_AS.
IPR003605;    TGF_beta_rcpt_GS.
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Pfam
PF01064;    Activin_recp;    1.
PF00069;    Pkinase;    1.
PF08515;    TGF_beta_GS;    1.
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SMART
SM00467;    GS;    1.
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PROSITE
PS51256;    GS;    1.
PS00107;    PROTEIN_KINASE_ATP;    1.
PS50011;    PROTEIN_KINASE_DOM;    1.
PS00108;    PROTEIN_KINASE_ST;    1.
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PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
SIGNAL        1     29       By similarity.
CHAIN        30    501       TGF-beta receptor type-1.
                             /FTId=PRO_0000024425.
TOPO_DOM     30    124       Extracellular (Potential).
TRANSMEM    125    145       Helical; (Potential).
TOPO_DOM    146    501       Cytoplasmic (Potential).
DOMAIN      173    202       GS.
DOMAIN      203    493       Protein kinase.
NP_BIND     209    217       ATP (By similarity).
MOTIF       191    192       FKBP1A-binding.
ACT_SITE    331    331       Proton acceptor (By similarity).
BINDING     230    230       ATP (By similarity).
MOD_RES     163    163       Phosphoserine (By similarity).
MOD_RES     183    183       Phosphothreonine; by TGFBR2 (By
                             similarity).
MOD_RES     184    184       Phosphothreonine; by TGFBR2 (By
                             similarity).
MOD_RES     185    185       Phosphoserine; by TGFBR2 (By similarity).
MOD_RES     187    187       Phosphoserine; by TGFBR2 (By similarity).
MOD_RES     189    189       Phosphoserine; by TGFBR2 (By similarity).
CARBOHYD     41     41       N-linked (GlcNAc...) (Potential).
DISULFID     32     50       By similarity.
DISULFID     34     37       By similarity.
DISULFID     44     67       By similarity.
DISULFID     82     94       By similarity.
DISULFID     95    100       By similarity.
CROSSLNK    389    389       Glycyl lysine isopeptide (Lys-Gly)
                             (interchain with G-Cter in SUMO).
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Nucleotide Sequence
Length: 1545 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 501 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
Pard6aIntAct 
Pard6aIntAct 
Pard3IntAct 
Tgfbr2IntAct 
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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