1. Y. Yamano, K. Ohyama, T. Sano, M. Ohta, A. Shimada, Y. Hirakawa, M. Sugimoto and I. Morishima (2001) A novel spermatogenesis-related factor-1 gene expressed in maturing rat testis.
Biochem Biophys Res Commun 289(4): 888-93.
Abstract
A rat gene with testis-specific expression coinciding with
spermatogenesis was cloned by differential display. This spermatogenesis-related factor-1 (SRF-1) gene was not expressed in other organs. Testicular expression was detected from 5 weeks of age and increased up to 15 weeks; this level of expression was maintained for 63 weeks. The 750-bp cloned gene was coded for an open reading frame of 202 amino acids. According to in situ hybridization at 7 weeks, this gene was expressed mainly in
spermatocyte. The gene product may function as a molecular motor in
meiosis, as the deduced amino acid sequence showed partial homology with kinesin-related proteins. The action of this gene and its product with respect to division of reproductive cells requires further investigation.
PMID: [11735130]