SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00001882 
UniProt Accession
Theoretical PI
8.9  
Molecular Weight
87406 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Smo 
Gene Synonyms/Alias
ORFNames=rCG_28227 
Protein Name
 
Protein Synonyms/Alias
SubName: Smoothened homologSubName: Smoothened homolog (Drosophila) 
Organism
Rattus norvegicus (Rat) 
NCBI Taxonomy ID
10116 
Chromosome Location
chr:4;56623494-56645571;1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. C. R. Morales, A. Fox, M. El-Alfy, X. Ni and W. S. Argraves (2009) Expression of Patched-1 and Smoothened in testicular meiotic and post-meiotic cells. Microsc Res Tech 72(11): 809-15. 

Abstract
Desert hedgehog (Dhh) signaling plays an essential role in the normal development of the testis and in the process of spermatogenesis. Little is known about the involvement in spermatogenesis of the prototypic member of the family, Ptc1, which acts to suppress hedgehog signaling through Smoothened (Smo). Here, we have examined the expression of Ptc1, Smo, and Dhh in mouse and rat seminiferous epithelium. Our findings demonstrate that Ptc1 and Smo are expressed by primary spermatocytes and by round and condensing spermatids whereas Dhh is expressed by Sertoli cells. The findings suggest that Sertoli cells coordinate Dhh-dependent spermatogenesis events via Ptc1 and Smo prior to the first meiotic division and in postmeiotic (haploid) cells, particularly during the first half of spermiogenesis. PMID: [19484749] 

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Figures for illustrating the function of this protein/gene
Ref: C. R. Morales, A. Fox, M. El-Alfy, X. Ni and W. S. Argraves (2009) Expression of Patched-1 and Smoothened in testicular meiotic and post-meiotic cells. Microsc Res Tech 72(11): 809-15. PMID: [19484749]
Ref: C. R. Morales, A. Fox, M. El-Alfy, X. Ni and W. S. Argraves (2009) Expression of Patched-1 and Smoothened in testicular meiotic and post-meiotic cells. Microsc Res Tech 72(11): 809-15. PMID: [19484749]
Ref: C. R. Morales, A. Fox, M. El-Alfy, X. Ni and W. S. Argraves (2009) Expression of Patched-1 and Smoothened in testicular meiotic and post-meiotic cells. Microsc Res Tech 72(11): 809-15. PMID: [19484749]
Ref: C. R. Morales, A. Fox, M. El-Alfy, X. Ni and W. S. Argraves (2009) Expression of Patched-1 and Smoothened in testicular meiotic and post-meiotic cells. Microsc Res Tech 72(11): 809-15. PMID: [19484749]
Function
 
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Subcellular Location
 
Tissue Specificity
 
Gene Ontology
GO IDGO termEvidence
GO:0016021 C:integral to membrane IEA:UniProtKB-KW.
GO:0004930 F:G-protein coupled receptor activity IEA:UniProtKB-KW.
GO:0007275 P:multicellular organismal development IEA:UniProtKB-KW.
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Interpro
IPR000539;    Frizzled.
IPR015526;    Frizzled/SFRP.
IPR020067;    Frizzled_dom.
IPR017981;    GPCR_2-like.
IPR026544;    SMO.
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Pfam
PF01534;    Frizzled;    1.
PF01392;    Fz;    1.
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SMART
SM00063;    FRI;    1.
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PROSITE
PS50038;    FZ;    1.
PS50261;    G_PROTEIN_RECEP_F2_4;    1.
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PRINTS
PR00489;    FRIZZLED.;   
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Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
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Nucleotide Sequence
Length: 189442 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 793 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
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