SG ID

SG00001886 

UniProt Accession

F1LRU0_RAT;F1LRU0;  

Theoretical PI

XXXX  

Molecular Weight

31774 Da  

Genbank Nucleotide ID

 

Genbank Protein ID

 

Gene Name

Igfbp3 

Gene Synonyms/Alias

 

Protein Name

 

Protein Synonyms/Alias

SubName: Insulin-like growth factor-binding protein 3 

Rattus norvegicus (Rat) 

10116 

Temporarily unavailable 

The information of related literatures

1. Y. Jia, K. W. Lee, R. Swerdloff, D. Hwang, L. J. Cobb, A. Sinha Hikim, Y. H. Lue, P. Cohen and C. Wang (2010) Interaction of insulin-like growth factor-binding protein-3 and BAX in mitochondria promotes male germ cell apoptosis. J Biol Chem 285(3): 1726-32. 

Abstract
Germ cell apoptosis is crucial for spermatogenesis and can be triggered by various stimuli, including intratesticular hormone deprivation. This study proposes a role for insulin-like growth factor binding protein-3 (IGFBP-3) in male germ cell apoptosis. Groups of adult Sprague-Dawley male rats received one of the following treatments for 5 days PMID: [19887447] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0005615	C:extracellular space	IEA:Compara.
GO:0005634	C:nucleus	IEA:Compara.
GO:0008160	F:protein tyrosine phosphatase activator activity	IEA:Compara.
GO:0001933	P:negative regulation of protein phosphorylation	IEA:Compara.
GO:0014912	P:negative regulation of smooth muscle cell migration	IEA:Compara.
GO:0048662	P:negative regulation of smooth muscle cell proliferation	IEA:Compara.
GO:0043065	P:positive regulation of apoptotic process	IEA:Compara.
GO:0043568	P:positive regulation of insulin-like growth factor receptor signaling pathway	IEA:Compara.
GO:0043410	P:positive regulation of MAPK cascade	IEA:Compara.
GO:0045663	P:positive regulation of myoblast differentiation	IEA:Compara.
GO:0006468	P:protein phosphorylation	IEA:Compara.
GO:0001558	P:regulation of cell growth	IEA:Compara.
GO:0010906	P:regulation of glucose metabolic process	IEA:Compara.
GO:0044342	P:type B pancreatic cell proliferation	IEA:Compara.

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Interpro

IPR009030;    Growth_fac_rcpt.
IPR012211;    IGFBP-3.
IPR000867;    IGFBP-like.
IPR009168;    IGFBP1-6.
IPR022321;    IGFBP_1-6_chordata.
IPR017891;    Insulin_GF-bd_Cys-rich_CS.
IPR000716;    Thyroglobulin_1.
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Pfam

PF00219;    IGFBP;    1.
PF00086;    Thyroglobulin_1;    1.
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SMART

SM00121;    IB;    1.
SM00211;    TY;    1.
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PROSITE

PS00222;    IGFBP_N_1;    1.
PS51323;    IGFBP_N_2;    1.
PS00484;    THYROGLOBULIN_1_1;    1.
PS51162;    THYROGLOBULIN_1_2;    1.
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PRINTS

PR01976;    IGFBPFAMILY.;   
PR01979;    IGFBPFAMILY3.;   
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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 292 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

Ref Databases

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

Ref Databases

View Microarray data

Temporarily unavailable 

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