SG ID

SG00001892 

UniProt Accession

F1LVW7_RAT;F1LVW7;  

Theoretical PI

FRAGMENT  

Molecular Weight

103660 Da  

Genbank Nucleotide ID

 

Genbank Protein ID

 

Gene Name

Diaph3 

Gene Synonyms/Alias

 

Protein Name

 

Protein Synonyms/Alias

SubName: Protein Diaph3Flags: Fragment 

Rattus norvegicus (Rat) 

10116 

Temporarily unavailable 

The information of related literatures

1. E. Mironova and C. F. Millette (2008) Expression of the diaphanous-related formin proteins mDia1 and mDia2 in the rat testis. Dev Dyn 237(8): 2170-6. 

Abstract
Cytoskeletal alterations in both Sertoli cells and germ cells are important during many facets of mammalian spermatogenesis. Diaphanous-related formin proteins are known to control many aspects of actin-based cytoskeletal rearrangements, yet nothing is known regarding the expression of formins in the testis. Accordingly, here we present the first data describing mDia1 and mDia2 mRNA and protein expression in primary Sertoli cell isolates, established tissue culture cell lines often used as models for Sertoli cell analysis, and mixed populations of adult rat male germ cells. Furthermore, we have examined intact sections of rat testis. The results suggest strongly that mDia1 and mDia2 are indeed involved in the regulation of Sertoli cell and germ structure during mammalian spermatogenesis, and provide strong indications of the future directions for mechanistic studies. PMID: [18651670] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0005737	C:cytoplasm	IDA:RGD.
GO:0005634	C:nucleus	IDA:RGD.
GO:0030036	P:actin cytoskeleton organization	IEA:InterPro.
GO:0007283	P:spermatogenesis	IEP:RGD.

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Interpro

IPR003104;    Actin-bd_FH2/DRF_autoreg.
IPR016024;    ARM-type_fold.
IPR014767;    Diaphanous_autoregulatory.
IPR010465;    Drf_DAD.
IPR010472;    Drf_FH3.
IPR010473;    Drf_GTPase-bd.
IPR015425;    FH2_actin-bd.
IPR014768;    GTPase-bd/formin_homology_3.
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Pfam

PF06345;    Drf_DAD;    1.
PF06367;    Drf_FH3;    1.
PF06371;    Drf_GBD;    1.
PF02181;    FH2;    1.
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SMART

SM00498;    FH2;    1.
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PROSITE

PS51231;    DAD;    1.
PS51444;    FH2;    1.
PS51232;    GBD_FH3;    1.
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PRINTS

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 904 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

Ref Databases

Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

Ref Databases

View Microarray data

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