SG00001900

SpermatogenesisOnline 1.0

Tag

Content

SG ID

SG00001900

UniProt Accession

F1LMN8_RAT;F1LMN8;

Theoretical PI

FRAGMENT

Molecular Weight

30692 Da

Genbank Nucleotide ID

Genbank Protein ID

Gene Name

Khdrbs3

Gene Synonyms/Alias

Protein Name

Protein Synonyms/Alias

SubName: KH domain-containing, RNA-binding, signal transduction-associated protein 3Flags: Fragment

Organism

Rattus norvegicus (Rat)

NCBI Taxonomy ID

10116

Chromosome Location

chr:7;106539015-106614738;1

View in Ensembl genome browser

Function in Stage

meiotic

Function in Cell Type

spermatocyte

Description

Temporarily unavailable

The information of related literatures

1. J. P. Venables, C. Vernet, S. L. Chew, D. J. Elliott, R. B. Cowmeadow, J. Wu, H. J. Cooke, K. Artzt and I. C. Eperon (1999) T-STAR/ETOILE. Hum Mol Genet 8(6): 959-69.

Abstract
RBM is an RNA-binding protein encoded on the Y chromosome in mammals and is expressed only in the nuclei of male germ cells. Genetic evidence from infertile men implicates it in spermatogenesis, but its function is unknown. Of a number of potential partners for RBM identified by a yeast two-hybrid screen with testis cDNA, the most frequent isolates encoded a novel RNA-binding protein, termed T-STAR, that is closely related to SAM68, an Src-associated protein of unknown function. The mouse homologue was also cloned and designated etoile. It mapped to chromosome 15, while T-STAR mapped to the syntenic region on human chromosome 8. T-STAR/etoile is expressed primarily in the testis; in rat germ cells, the expression of both T-STAR/etoile and SAM68 is regulated during meiosis. Transfection of T-STAR/etoile fused with green fluorescent protein into HeLa cells caused an accumulation of protein in a novel compartment of the nucleus, adjacent to the nucleolus but distinct from the peri-nucleolar compartment. RBM and other hnRNP G family members are candidate downstream targets for regulation by T-STAR/ETOILE and SAM68. PMID: [10332027]

Figures for illustrating the function of this protein/gene

	Ref: J. P. Venables, C. Vernet, S. L. Chew, D. J. Elliott, R. B. Cowmeadow, J. Wu, H. J. Cooke, K. Artzt and I. C. Eperon (1999) T-STAR/ETOILE. Hum Mol Genet 8(6): 959-69. PMID: [10332027]
	Ref: J. P. Venables, C. Vernet, S. L. Chew, D. J. Elliott, R. B. Cowmeadow, J. Wu, H. J. Cooke, K. Artzt and I. C. Eperon (1999) T-STAR/ETOILE. Hum Mol Genet 8(6): 959-69. PMID: [10332027]
	Ref: J. P. Venables, C. Vernet, S. L. Chew, D. J. Elliott, R. B. Cowmeadow, J. Wu, H. J. Cooke, K. Artzt and I. C. Eperon (1999) T-STAR/ETOILE. Hum Mol Genet 8(6): 959-69. PMID: [10332027]