SG ID

SG00001907 

UniProt Accession

F1LRG5_RAT;F1LRG5;  

Theoretical PI

5.09  

Molecular Weight

14837 Da  

Genbank Nucleotide ID

 

Genbank Protein ID

 

Gene Name

Lgals1 

Gene Synonyms/Alias

 

Protein Name

 

Protein Synonyms/Alias

SubName: Galectin-1 

Rattus norvegicus (Rat) 

10116 

Temporarily unavailable 

The information of related literatures

1. L. Dettin, N. Rubinstein, A. Aoki, G. A. Rabinovich and C. A. Maldonado (2003) Regulated expression and ultrastructural localization of galectin-1, a proapoptotic beta-galactoside-binding lectin, during spermatogenesis in rat testis. Biol Reprod 68(1): 51-9. 

Abstract
Galectin-1, a highly conserved beta-galactoside-binding protein, induces apoptosis of activated T cells and suppresses the development of autoimmunity and chronic inflammation. To gain insight regarding the potential role of galectin-1 as a novel mechanism of immune privilege, we investigated expression and ultrastructural localization of galectin-1 in rat testis. Galectin-1 expression was assessed by Western blot analysis and immunocytochemical localization in testes obtained from rats aged from 9 to 60 days. Expression of this carbohydrate-binding protein was developmentally regulated, and its immunolabeling exhibited a stage-specific pattern throughout the spermatogenic process. Immunogold staining using the anti-galectin-1 antibody revealed the typical Sertoli cell profile in the seminiferous epithelium, mainly at stages X-II. During spermiation (stages VI-VIII), a strong labeling was observed at the luminal pole of seminiferous epithelium, localized on apical stalks of Sertoli cells, on heads of mature spermatids, and on bodies of residual cytoplasm. Moreover, spermatozoa released into the lumen showed a strong immunostaining. Following spermiation (stage VIII), galectin-1 expression was restored at the basal portion of Sertoli cells and progressively spread out through the whole cells as differentiation of germinal cells proceeded. Immunoelectron microscopy confirmed distribution of galectin-1 in nuclei and cytoplasmic projections of Sertoli cells and on heads and tails of late spermatids and residual bodies. Surface localization of galectin-1 was evidenced in spermatozoa from caput epididymis. Thus, the regulated expression of galectin-1 during the spermatogenic cycle suggests a novel role for this immunosuppressive lectin in reproductive biology. PMID: [12493695] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0031012	C:extracellular matrix	IEA:Compara.
GO:0005615	C:extracellular space	IEA:Compara.
GO:0005622	C:intracellular	IEA:Compara.
GO:0016936	F:galactoside binding	IEA:InterPro.
GO:0004871	F:signal transducer activity	IEA:Compara.
GO:0045445	P:myoblast differentiation	IEA:Compara.
GO:0043123	P:positive regulation of I-kappaB kinase/NF-kappaB cascade	IEA:Compara.

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Interpro

IPR008985;    ConA-like_lec_gl.
IPR013320;    ConA-like_subgrp.
IPR015535;    Galectin_1.
IPR001079;    Galectin_CRD.
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Pfam

PF00337;    Gal-bind_lectin;    1.
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SMART

SM00908;    Gal-bind_lectin;    1.
SM00276;    GLECT;    1.
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PROSITE

PS51304;    GALECTIN;    1.
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PRINTS

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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: bp   Go to nucleotide: FASTA

Protein Sequence

Length: 135 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

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Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

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View Microarray data

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