SG ID

SG00001913 

UniProt Accession

Q6IRG7_RAT;Q6IRG7;  

Theoretical PI

8.23  

Molecular Weight

22114 Da  

Genbank Nucleotide ID

BC070927; CH473961;  

Genbank Protein ID

AAH70927.1; EDM01147.1; 

Gene Name

Cldn11 

Gene Synonyms/Alias

ORFNames=rCG_41381 

Protein Name

 

Protein Synonyms/Alias

SubName: Claudin 11SubName: Claudin-11 

Rattus norvegicus (Rat) 

10116 

Temporarily unavailable 

The information of related literatures

1. A. Florin, M. Maire, A. Bozec, A. Hellani, S. Chater, R. Bars, F. Chuzel and M. Benahmed (2005) Androgens and postmeiotic germ cells regulate claudin-11 expression in rat Sertoli cells. Endocrinology 146(3): 1532-40. 

Abstract
In the present study we investigated whether fetal exposure to flutamide affected messenger and protein levels of claudin-11, a key Sertoli cell factor in the establishment of the hemotesticular barrier, at the time of two key events of postnatal testis development PMID: [15591150] 

2. T. J. Kaitu'u-Lino, P. Sluka, C. F. Foo and P. G. Stanton (2007) Claudin-11 expression and localisation is regulated by androgens in rat Sertoli cells in vitro. Reproduction 133(6): 1169-79. 

Abstract
Claudin-11 and occludin are protein components in tight junctions (TJs) between Sertoli cells which are important for the maintenance of the blood-testis barrier. Barrier formation occurs during puberty, with evidence suggesting hormonal regulation of both claudin-11 and occludin. This study aimed to investigate the regulation of claudin-11 and occludin mRNA expression by testosterone (T) and FSH and their immunolocalisation at rat Sertoli cell TJs in vitro, and to correlate any steroid regulation with the functional capacity of TJs. Sertoli cells formed functional TJs within 3 days as assessed by transepithelial electrical resistance (TER). Both T and dihydrotestosterone significantly (P < 0.01) increased TER twofold and claudin-11 mRNA two- to threefold within 3 days. FSH partially stimulated TER and claudin-11 mRNA, but estradiol had no effect. T also promoted claudin-11 localisation into extensive intercellular contacts. In contrast to claudin-11, Tand FSH did not change occludin mRNA expression, however, T promoted localisation of occludin at cell contacts in a similar manner to claudin-11. Addition of flutamide to T-stimulated cells caused a twofold decrease in both TER and claudin-11 mRNA expression, and resulted in the loss of both proteins from cell contacts. This effect was reversible following flutamide removal. It is concluded that androgens i) co-regulate claudin-11 mRNA expression and TER, implicating claudin-11 in TJ formation and ii) promote the localisation of claudin-11 and occludin at Sertoli cell contacts. Hence, the ability of androgens to maintain spermatogenesis in vivo is partly via their effects on TJ proteins and regulation of the blood-testis barrier. PMID: [17636171] 

Figures for illustrating the function of this protein/gene

Function

 

Subcellular Location

 

Tissue Specificity

 

Gene Ontology

GO ID	GO term	Evidence
GO:0016021	C:integral to membrane	IEA:UniProtKB-KW.
GO:0005923	C:tight junction	IEA:UniProtKB-KW.
GO:0005198	F:structural molecule activity	IEA:InterPro.
GO:0008366	P:axon ensheathment	IEA:Compara.
GO:0007155	P:cell adhesion	IEA:Compara.
GO:0007283	P:spermatogenesis	IEA:Compara.

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Interpro

IPR006187;    Claudin.
IPR003555;    Claudin11.
IPR017974;    Claudin_CS.
IPR004031;    PMP22/EMP/MP20/Claudin.
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Pfam

PF00822;    PMP22_Claudin;    1.
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SMART

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PROSITE

PS01346;    CLAUDIN;    1.
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PRINTS

PR01077;    CLAUDIN.;   
PR01384;    CLAUDIN11.;   
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Created Date

18-Oct-2012 

Record Type

Experiment identified 

Protein sequence Annotation

Nucleotide Sequence

Length: 1873 bp   Go to nucleotide: FASTA

Protein Sequence

Length: 207 bp   Go to amino acid: FASTA

The verified Protein-Protein interaction information

UniProt

Gene Symbol

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Other Protein-Protein interaction resources

String database  

UniProt

Gene Symbol

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View Microarray data

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