SpermatogenesisOnline 1.0
 

Tag Content
SG ID
SG00001915 
UniProt Accession
Theoretical PI
5.16  
Molecular Weight
40779 Da  
Genbank Nucleotide ID
Genbank Protein ID
Gene Name
Ndrg2 
Gene Synonyms/Alias
 
Protein Name
Protein NDRG2 
Protein Synonyms/Alias
Antidepressant-related protein ADRG123; N-myc downstream-regulated gene 2 protein; NDRG1-related protein; 
Organism
Rattus norvegicus (Rat) 
NCBI Taxonomy ID
10116 
Chromosome Location
chr:15;27338552-27347196;-1
View in Ensembl genome browser  
Function in Stage
Function in Cell Type
Description
Temporarily unavailable 
The information of related literatures
1. W. G. Hou, Y. Zhao, L. Shen, J. Zhao, X. W. Liu, Z. Li, X. P. Liu, L. B. Yao and Y. Q. Zhang (2009) Differential expression of N-Myc downstream regulated gene 2 (NDRG2) in the rat testis during postnatal development. Cell Tissue Res 337(2): 257-67. 

Abstract
N-Myc downstream regulated gene 2 (NDRG2) is expressed in the testis of adult animals and is involved in cell differentiation and development. However, little is known about the expression pattern of NDRG2 in the testis during postnatal development. Here, we show that NDRG2 is consistently expressed in Leydig cells in the rat testis during postnatal development. However, its expression has also been detected at a high frequency in spermatogenic cells of the seminiferous tubules in young rats but at a much lower frequency in adult rats. Furthermore, high levels of NDRG2 expression have been found in methoxyacetic-acid-induced apoptotic germ cells, particularly at stages X-XIII of the seminiferous epithelium cycle of adult rats. Interestingly, high levels of NDRG2 expression have also been observed in spontaneously apoptotic germ cells in the seminiferous tubules of young and adult rats. Thus, the expression of NDRG2 in germ cells seems to alter during spermatogenesis. These findings suggest that NDRG2 regulates testicular development and spermatogenesis in rats and is involved in the physiological and pathological apoptosis of germ cells. PMID: [19471968] 

Back to Top
Figures for illustrating the function of this protein/gene
Ref: W. G. Hou, Y. Zhao, L. Shen, J. Zhao, X. W. Liu, Z. Li, X. P. Liu, L. B. Yao and Y. Q. Zhang (2009) Differential expression of N-Myc downstream regulated gene 2 (NDRG2) in the rat testis during postnatal development. Cell Tissue Res 337(2): 257-67. PMID: [19471968]
Ref: W. G. Hou, Y. Zhao, L. Shen, J. Zhao, X. W. Liu, Z. Li, X. P. Liu, L. B. Yao and Y. Q. Zhang (2009) Differential expression of N-Myc downstream regulated gene 2 (NDRG2) in the rat testis during postnatal development. Cell Tissue Res 337(2): 257-67. PMID: [19471968]
Ref: W. G. Hou, Y. Zhao, L. Shen, J. Zhao, X. W. Liu, Z. Li, X. P. Liu, L. B. Yao and Y. Q. Zhang (2009) Differential expression of N-Myc downstream regulated gene 2 (NDRG2) in the rat testis during postnatal development. Cell Tissue Res 337(2): 257-67. PMID: [19471968]
Ref: W. G. Hou, Y. Zhao, L. Shen, J. Zhao, X. W. Liu, Z. Li, X. P. Liu, L. B. Yao and Y. Q. Zhang (2009) Differential expression of N-Myc downstream regulated gene 2 (NDRG2) in the rat testis during postnatal development. Cell Tissue Res 337(2): 257-67. PMID: [19471968]
Ref: W. G. Hou, Y. Zhao, L. Shen, J. Zhao, X. W. Liu, Z. Li, X. P. Liu, L. B. Yao and Y. Q. Zhang (2009) Differential expression of N-Myc downstream regulated gene 2 (NDRG2) in the rat testis during postnatal development. Cell Tissue Res 337(2): 257-67. PMID: [19471968]
Function
Contributes to the regulation of the Wnt signalingpathway. Down-regulates CTNNB1-mediated transcriptional activationof target genes, such as CCND1, and may thereby act as tumorsuppressor (By similarity). May be involved in dendritic cell andneuron differentiation. 
Back to Top
Subcellular Location
Cytoplasm (By similarity). Cytoplasm,perinuclear region (By similarity). Cell projection, growth cone.Note=In neurons, seems to concentrate at axonal growth cone. 
Tissue Specificity
Broadly expressed, with highest levels inheart, liver, skeletal muscle and aorta. 
Gene Ontology
GO IDGO termEvidence
GO:0030426 C:growth cone IEA:UniProtKB-SubCell.
GO:0005634 C:nucleus IEA:Compara.
GO:0048471 C:perinuclear region of cytoplasm IEA:UniProtKB-SubCell.
GO:0030154 P:cell differentiation IEA:UniProtKB-KW.
GO:0001818 P:negative regulation of cytokine production IEA:Compara.
GO:0070373 P:negative regulation of ERK1 and ERK2 cascade IEA:Compara.
GO:0048662 P:negative regulation of smooth muscle cell proliferation IEA:Compara.
GO:0007399 P:nervous system development IEA:UniProtKB-KW.
GO:0090361 P:regulation of platelet-derived growth factor production IEA:Compara.
GO:0010574 P:regulation of vascular endothelial growth factor production IEA:Compara.
GO:0007165 P:signal transduction IDA:RGD.
GO:0016055 P:Wnt receptor signaling pathway IEA:UniProtKB-KW.
Back to Top
Interpro
Pfam
PF03096;    Ndr;    1.
Back to Top
SMART
PROSITE
PRINTS
Created Date
18-Oct-2012 
Record Type
Experiment identified 
Protein sequence Annotation
INIT_MET      1      1       Removed (By similarity).
CHAIN         2    371       Protein NDRG2.
                             /FTId=PRO_0000238966.
MOD_RES       2      2       N-acetylalanine (By similarity).
MOD_RES     326    326       Phosphoserine (By similarity).
MOD_RES     328    328       Phosphoserine (By similarity).
MOD_RES     330    330       Phosphothreonine (By similarity).
MOD_RES     332    332       Phosphoserine.
MOD_RES     334    334       Phosphothreonine (By similarity).
MOD_RES     335    335       Phosphoserine (By similarity).
MOD_RES     338    338       Phosphoserine.
MOD_RES     342    342       Phosphoserine (By similarity).
MOD_RES     344    344       Phosphoserine (By similarity).
MOD_RES     346    346       Phosphoserine (By similarity).
MOD_RES     348    348       Phosphothreonine (By similarity).
MOD_RES     350    350       Phosphoserine (By similarity).
MOD_RES     352    352       Phosphoserine (By similarity).
MOD_RES     353    353       Phosphoserine (By similarity).
MOD_RES     355    355       Phosphoserine (By similarity).
MOD_RES     357    357       Phosphothreonine (By similarity).
VAR_SEQ      26     39       Missing (in isoform 2).
                             /FTId=VSP_019032.
CONFLICT    121    121       Q -> L (in Ref. 2; AAL73186/AAL73187).
Back to Top
Nucleotide Sequence
Length: 2040 bp   Go to nucleotide: FASTA
Protein Sequence
Length: 371 bp   Go to amino acid: FASTA
The verified Protein-Protein interaction information
UniProt
 Gene Symbol Ref Databases
Other Protein-Protein interaction resources
String database  
View Microarray data
Temporarily unavailable 
Comments